Publication:
The expression of common fragile sites and genetic predisposition to squamous cell lung cancers

dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorKaradağ, Mehmet
dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorÖzyardımcı, Nihat
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentGöğüs Hastalıkları Ana Bilim Dalı
dc.contributor.departmentMoleküler Biyoloji Bölümü
dc.contributor.orcid0000-0002-1619-6680
dc.contributor.orcid0000-0002-9027-1132
dc.contributor.researcheridABI-6078-2020
dc.contributor.researcheridAAG-8744-2021
dc.date.accessioned2021-07-05T11:29:07Z
dc.date.available2021-07-05T11:29:07Z
dc.date.issued1997
dc.description.abstractThe chromosomal aberration rates (including gaps and breaks) and expression frequency of fragile sites were determined in peripheral blood lymphocytes cultured with TC 199 medium from 8 patients with squamous cell lung cancer, 10 of their first-degree relatives, and 12 healthy control subjects. As a result of cytogenetic evaluation, both the chromosomal aberration rates and expression frequencies of common fragile sites observed in patients and their relatives were significantly higher than those in healthy control subjects. Our results showed that common fragile sites might be unstable factors in the human genome, and their expression might be affected by some genetic and environmental factors. As a result of this they might play an important role in genetic predisposition to lung cancer. The high expression of fra(3)(p14) in patients and their relatives may be a valid marker for genetic predisposition to lung cancer.
dc.identifier.citationEgeli, Ü. vd. (1997). "The expression of common fragile sites and genetic predisposition to squamous cell lung cancers". Cancer Genetics and Cytogenetics, 95(2), 153-158.
dc.identifier.endpage158
dc.identifier.issn0165-4608
dc.identifier.issue2
dc.identifier.pubmed9169033
dc.identifier.scopus2-s2.0-0031010323
dc.identifier.startpage153
dc.identifier.urihttps://doi.org/10.1016/S0165-4608(96)00215-4
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0165460896002154
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/9169033/
dc.identifier.urihttp://hdl.handle.net/11452/21069
dc.identifier.volume95
dc.identifier.wosA1997XA83100006
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier Science
dc.relation.journalCancer Genetics and Cytogenetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOncology
dc.subjectGenetics & heredity
dc.subjectChromosome breakpoints
dc.subjectAphidicolin
dc.subjectLymphocytes
dc.subjectRegion
dc.subject.wosOncology
dc.subject.wosGenetics & heredity
dc.titleThe expression of common fragile sites and genetic predisposition to squamous cell lung cancers
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Moleküler Biyoloji Bölümü
local.contributor.departmentTıp Fakültesi/Göğüs Hastalıkları Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

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