Publication:
Kinetics of hepatitis B surface antigen loss in patients with HBeAg-positive chronic hepatitis B treated with tenofovir disoproxil fumarate

dc.contributor.authorMarcellin, Patrick
dc.contributor.authorButi, Maria
dc.contributor.authorKrastev, Zahari
dc.contributor.authorde Man, Robert A.
dc.contributor.authorZeuzem, Stefan
dc.contributor.authorLou, Lillian
dc.contributor.authorGaggar, Anuj
dc.contributor.authorFlaherty, John F.
dc.contributor.authorMassetto, Benedetta
dc.contributor.authorLin, Lanjia
dc.contributor.authorDinh, Phillip
dc.contributor.authorSubramanian, G. Mani
dc.contributor.authorMcHutchison, John G.
dc.contributor.authorFlisiak, Robert
dc.contributor.authorGürel, Selim
dc.contributor.authorDusheiko, Geoffrey M.
dc.contributor.authorHeathcote, E. Jenny
dc.contributor.buuauthorGÜREL, SELİM
dc.contributor.departmentUludag Üniversitesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.researcheridHLH-8209-2023
dc.date.accessioned2024-08-15T07:51:49Z
dc.date.available2024-08-15T07:51:49Z
dc.date.issued2014-07-11
dc.description.abstractBackground & Aims: In a study of 266 chronic hepatitis B e antigen (HBeAg)-positive patients, 23 experienced hepatitis B surface antigen (HBsAg) loss with up to 5 years of tenofovir disoproxil fumarate (TDF) treatment. HBsAg kinetics in patients with and without HBsAg loss and predictors of HBsAg loss were evaluated.Methods: HBsAg levels were quantified every 12 weeks. A multivariable regression analysis, involving prespecified baseline characteristics and on-treatment response parameters, was performed; a stepwise procedure identified independent predictors of HBsAg loss.Results: Among patients with HBsAg loss, 14 (61%), 1 (4%), 0 and 7 (30%) were genotypes A through D, respectively; 1 (4%) was genotype F. HBsAg loss was preceded by viral suppression (HBV DNA < 29 IU/ml; n = 23) and HBeAg loss (n = 19). Among treated patients the strongest independent predictors of HBsAg loss were Caucasian race with genotype A/D and 64 years of infection (HR = 14.3, 95% confidence interval [CI] 4.7-43.4; p < 0.0001) and an HBsAg decline of >= 1 log(10) IU/ml at week 24 (HR = 13.7, 95% CI 5.6-33.7; p < 0.0001). Among TDF-treated patients, a reduction in HBsAg level of >= 1-log(10) by week 12 or 24 had a positive predictive value of 35%-45%, respectively, and a negative predictive value of 94%-97%, respectively.Conclusions: HBsAg loss in HBeAg-positive patients receiving TDF involves a chronology of virologic and serologic responses; patients with HBV genotypes A or D and a rapid early decline in HBsAg are more likely to lose HBsAg.
dc.description.sponsorshipGilead Sciences
dc.identifier.doi10.1016/j.jhep.2014.07.019
dc.identifier.endpage1237
dc.identifier.issn0168-8278
dc.identifier.issue6
dc.identifier.startpage1228
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0168827814005182
dc.identifier.urihttps://hdl.handle.net/11452/44041
dc.identifier.volume61
dc.identifier.wos000345115600008
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherElsevier
dc.relation.journalJournal of Hepatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSustained virological response
dc.subjectPolymerase chain-reaction
dc.subjectTerm-follow-up
dc.subjectPeginterferon alpha-2a
dc.subjectNucleos(t)ide analog
dc.subjectNegative patients
dc.subjectHbsag loss
dc.subjectVirus-dna
dc.subjectSerum
dc.subjectTherapy
dc.subjectChronic hepatitis b
dc.subjectHepatitis b surface antigen
dc.subjectTenofovir disoproxil fumarate
dc.subjectGastroenterology & hepatology
dc.titleKinetics of hepatitis B surface antigen loss in patients with HBeAg-positive chronic hepatitis B treated with tenofovir disoproxil fumarate
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentUludag Üniversitesi/Tıp Fakültesi
relation.isAuthorOfPublicationd7a9ea11-69fc-4122-a365-8fb2123512e6
relation.isAuthorOfPublication.latestForDiscoveryd7a9ea11-69fc-4122-a365-8fb2123512e6

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Gurel_vd_2014.pdf
Size:
1.39 MB
Format:
Adobe Portable Document Format

Collections