Publication:
The effect of benzene on serum hormones and the activity of some enzymes in different tissues of rats

dc.contributor.authorGyborova, Suriye
dc.contributor.authorAydın, Hüseyin
dc.contributor.buuauthorDere, Egemen
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentBiyoloji Bölümü
dc.contributor.researcheridAAH-5068-2021
dc.contributor.scopusid6603627015
dc.date.accessioned2022-05-10T06:10:59Z
dc.date.available2022-05-10T06:10:59Z
dc.date.issued2003
dc.description.abstractThe effects of a 100 mg.kg(-1) dose, of benzene, an occupational and environmental toxicant, were investigated on serum, estradiol and testosterone concentrations as well as lactate dehydrogenase (LDH), alkaline phosphatase (ALP), alanine amino transferase (ALT), aspartate amino transferase (AST), and pyruvate kinase (PK) activities in the liver and kidney of rats after 2, 4, 8, 16, 32, 64 and 72 hours. Benzene was given intraperitoneally to Rat rattus norvegicus and the control groups were injected with physiological saline. Liver tissue LDH, AST, ALT and kidney tissue LDH, ALP, AST, ALT activities were lower in the benzene treated group when compared to those in the control group (p<0.05). A tendency for an increase in the liver tissue ALP activity was observed, which was significant at 8 and 16 hours (p<0.05). There were significant increases in ALT in the liver and LDH, AST, and ALT enzyme activities in the kidney tissue at the beginning of the experiment in both groups and these activities were found to be nearly the same. Pyruvate kinase enzyme activities in rats given benzene were slightly increased in kidney tissues but lower in liver tissues. Differences between the groups tended to disappear towards the end of the experimental period. However, serum estradiol concentrations in the serum diverged significantly (p<0.05). Consequently, it was found that benzene administration led to some changes (increases then decreases) in LDH, ALP, ALT, AST, and PK activity and estradiol, testosterone concentrations in different tissues of rats. Possible causes of the increases and decreases in enzyme activities and hormone levels are discussed.
dc.identifier.citationDere, E. vd. (2003). “The effect of benzene on serum hormones and the activity of some enzymes in different tissues of rats”. Acta Veterinaria-Beograd, 53(2-3), 87-101.
dc.identifier.endpage101
dc.identifier.issn0567-8315
dc.identifier.issue2-3
dc.identifier.scopus2-s2.0-0038161263
dc.identifier.startpage87
dc.identifier.urihttps://doi.org/10.2298/AVB0303087D
dc.identifier.urihttp://www.doiserbia.nb.rs/img/doi/0567-8315/2003/0567-83150303087D.pdf
dc.identifier.urihttp://hdl.handle.net/11452/26343
dc.identifier.volume53
dc.identifier.wos000183706800003
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSciendo
dc.relation.collaborationYurt içi
dc.relation.journalActa Veterinaria-Beograd
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVeterinary sciences
dc.subjectBenzene
dc.subjectLiver
dc.subjectKidney
dc.subjectEnzyme
dc.subjectSerum hormone
dc.subjectMicrosomal membrane
dc.subjectIn-vitro
dc.subjectMouse
dc.subjectMetabolism
dc.subjectLiver
dc.subjectCells
dc.subject1,4-bis<2-(3,5-dichloropyridyloxy)>benzene
dc.subjectHydroquinone
dc.subjectGlutathione
dc.subjectToxicity
dc.subjectAnimalia
dc.subjectRattus
dc.subjectRattus norvegicus
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeControlled study
dc.subject.emtreeEnzyme activity
dc.subject.emtreeEstradiol blood level
dc.subject.emtreeHormone determination
dc.subject.emtreeKidney
dc.subject.emtreeLiver
dc.subject.emtreeMale
dc.subject.emtreeNonhuman
dc.subject.emtreeRat
dc.subject.emtreeTestosterone blood level
dc.subject.emtreeTissue distribution
dc.subject.emtreeTissue level
dc.subject.emtreeToxicity
dc.subject.emtreeAlanine aminotransferase
dc.subject.emtreeAlkaline phosphatase
dc.subject.emtreeAspartate aminotransferase
dc.subject.emtreeBenzene
dc.subject.emtreeIsoenzyme
dc.subject.emtreeLactate dehydrogenase
dc.subject.emtreePyruvate kinase
dc.subject.scopusS-Phenyl-N-Acetylcysteine; Muconic Acid; Occupational Exposure
dc.subject.wosVeterinary sciences
dc.titleThe effect of benzene on serum hormones and the activity of some enzymes in different tissues of rats
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Bölümü
local.indexed.atScopus
local.indexed.atWOS

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