Publication:
Anti-genotoxic effect of naringin against bleomycin-induced genomic damage in human lymphocytes in vitro

dc.contributor.buuauthorYılmaz, Dilek
dc.contributor.buuauthorTeksoy, Özgün
dc.contributor.buuauthorBilaloğlu, Rahmi
dc.contributor.buuauthorÇinkılıç, Nilüfer
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentBiyoloji Bölümü
dc.contributor.departmentHücre Kültürü ve Genetik Toksikoloji Laboratuvarı
dc.contributor.orcid0000-0002-3595-6286
dc.contributor.researcheridAAH-5296-2021
dc.contributor.scopusid6701369462
dc.contributor.scopusid57113710400
dc.contributor.scopusid6505804122
dc.contributor.scopusid26533892300
dc.date.accessioned2022-12-06T05:50:27Z
dc.date.available2022-12-06T05:50:27Z
dc.date.issued2015-04-07
dc.description.abstractNaringin is a flavonoid found in grapefruit and other citrus fruits that shows antioxidant activity. The aim of the present study was to determine the anti-genotoxic and protective effects of naringin on the chemotherapeutic/radiomimetic agent bleomycin (BLM) in human blood lymphocyte cultures in vitro using micronucleus test and chromosomal aberrations (CA) assay. We tested the three doses of naringin (1, 2, 3 mu g/mL) and a single dose of BLM (20 mu g/mL). BLM significantly increased the total CAs and micronucleus frequency at a concentration of 20 mu g/mL. Naringin did not show any toxicity in doses of 1, 2, and 3 mu g/mL. Combined treatments of BLM and naringin (2 and 3 mu g/mL) significantly reduced micronucleus formation. Naringin dose-dependently decreased the total chromosome aberrations frequency induced by BLM. These results indicate that naringin could prevent BLM (20 mu g/mL)-induced genotoxicity.
dc.identifier.citationYılmaz, D. vd. (2016). "Anti-genotoxic effect of naringin against bleomycin-induced genomic damage in human lymphocytes in vitro". Drug and Chemical Toxicology, 39(2), 119-123.
dc.identifier.endpage123
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue2
dc.identifier.pubmed25941869
dc.identifier.scopus2-s2.0-84957975104
dc.identifier.startpage119
dc.identifier.urihttps://doi.org/10.3109/01480545.2015.1039647
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.3109/01480545.2015.1039647
dc.identifier.urihttp://hdl.handle.net/11452/29681
dc.identifier.volume39
dc.identifier.wos000370663300001
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.journalDrug and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChemistry
dc.subjectPharmacology & pharmacy
dc.subjectMicronucleus
dc.subjectChromosome aberration assay
dc.subjectNaringin
dc.subjectChemotherapeutic/radiomimetic agent
dc.subjectBleomycin
dc.subjectFlavonoid
dc.subjectRadical scavenging activity
dc.subjectAntioxidant properties
dc.subjectHydrogen-peroxide
dc.subjectDna-damage
dc.subjectCells
dc.subjectRats
dc.subjectCytotoxicity
dc.subjectMechanisms
dc.subjectFlavonoids
dc.subjectRutin
dc.subjectToxicology
dc.subject.emtreeAurantiin
dc.subject.emtreeBleomycin
dc.subject.emtreeAntimutagenic agent
dc.subject.emtreeAurantiin
dc.subject.emtreeBleomycin
dc.subject.emtreeFlavanone derivative
dc.subject.emtreeAdult
dc.subject.emtreeAnti genotoxic activity
dc.subject.emtreeArticle
dc.subject.emtreeCell protection
dc.subject.emtreeChromosome aberration
dc.subject.emtreeChromosome aberration assay
dc.subject.emtreeConcentration response
dc.subject.emtreeControlled study
dc.subject.emtreeDNA damage
dc.subject.emtreeDrug activity
dc.subject.emtreeDrug efficacy
dc.subject.emtreeFemale
dc.subject.emtreeGenetic toxicology
dc.subject.emtreeGenotoxicity
dc.subject.emtreeGenotoxicity assay
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeIn vitro study
dc.subject.emtreeLymphocyte culture
dc.subject.emtreeLymphocytotoxicity
dc.subject.emtreeMale
dc.subject.emtreeMicronucleus
dc.subject.emtreeMicronucleus test
dc.subject.emtreeNormal human
dc.subject.emtreeAdolescent
dc.subject.emtreeCell culture
dc.subject.emtreeCell culture technique
dc.subject.emtreeChemically induced
dc.subject.emtreeDNA damage
dc.subject.emtreeDose response
dc.subject.emtreeDrug effects
dc.subject.emtreeLymphocyte
dc.subject.emtreeUltrastructure
dc.subject.emtreeYoung adult
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAntimutagenic agents
dc.subject.meshBleomycin
dc.subject.meshCell culture techniques
dc.subject.meshCells, cultured
dc.subject.meshDNA damage
dc.subject.meshDose-response relationship, drug
dc.subject.meshFemale
dc.subject.meshFlavanones
dc.subject.meshHumans
dc.subject.meshLymphocytes
dc.subject.meshMale
dc.subject.meshMicronuclei, chromosome-defective
dc.subject.meshYoung adult
dc.subject.scopusBleomycin; Streptomyces Verticillus; DNA
dc.subject.wosChemistry, multidisciplinary
dc.subject.wosPharmacology & pharmacy
dc.subject.wosToxicology
dc.titleAnti-genotoxic effect of naringin against bleomycin-induced genomic damage in human lymphocytes in vitro
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Bölümü/Hücre Kültürü ve Genetik Toksikoloji Laboratuvarı
local.indexed.atScopus
local.indexed.atWOS

Files

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: