Publication: Anti-genotoxic effect of naringin against bleomycin-induced genomic damage in human lymphocytes in vitro
dc.contributor.buuauthor | Yılmaz, Dilek | |
dc.contributor.buuauthor | Teksoy, Özgün | |
dc.contributor.buuauthor | Bilaloğlu, Rahmi | |
dc.contributor.buuauthor | Çinkılıç, Nilüfer | |
dc.contributor.department | Fen Edebiyat Fakültesi | |
dc.contributor.department | Biyoloji Bölümü | |
dc.contributor.department | Hücre Kültürü ve Genetik Toksikoloji Laboratuvarı | |
dc.contributor.orcid | 0000-0002-3595-6286 | |
dc.contributor.researcherid | AAH-5296-2021 | |
dc.contributor.scopusid | 6701369462 | |
dc.contributor.scopusid | 57113710400 | |
dc.contributor.scopusid | 6505804122 | |
dc.contributor.scopusid | 26533892300 | |
dc.date.accessioned | 2022-12-06T05:50:27Z | |
dc.date.available | 2022-12-06T05:50:27Z | |
dc.date.issued | 2015-04-07 | |
dc.description.abstract | Naringin is a flavonoid found in grapefruit and other citrus fruits that shows antioxidant activity. The aim of the present study was to determine the anti-genotoxic and protective effects of naringin on the chemotherapeutic/radiomimetic agent bleomycin (BLM) in human blood lymphocyte cultures in vitro using micronucleus test and chromosomal aberrations (CA) assay. We tested the three doses of naringin (1, 2, 3 mu g/mL) and a single dose of BLM (20 mu g/mL). BLM significantly increased the total CAs and micronucleus frequency at a concentration of 20 mu g/mL. Naringin did not show any toxicity in doses of 1, 2, and 3 mu g/mL. Combined treatments of BLM and naringin (2 and 3 mu g/mL) significantly reduced micronucleus formation. Naringin dose-dependently decreased the total chromosome aberrations frequency induced by BLM. These results indicate that naringin could prevent BLM (20 mu g/mL)-induced genotoxicity. | |
dc.identifier.citation | Yılmaz, D. vd. (2016). "Anti-genotoxic effect of naringin against bleomycin-induced genomic damage in human lymphocytes in vitro". Drug and Chemical Toxicology, 39(2), 119-123. | |
dc.identifier.endpage | 123 | |
dc.identifier.issn | 0148-0545 | |
dc.identifier.issn | 1525-6014 | |
dc.identifier.issue | 2 | |
dc.identifier.pubmed | 25941869 | |
dc.identifier.scopus | 2-s2.0-84957975104 | |
dc.identifier.startpage | 119 | |
dc.identifier.uri | https://doi.org/10.3109/01480545.2015.1039647 | |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.3109/01480545.2015.1039647 | |
dc.identifier.uri | http://hdl.handle.net/11452/29681 | |
dc.identifier.volume | 39 | |
dc.identifier.wos | 000370663300001 | |
dc.indexed.wos | SCIE | |
dc.language.iso | en | |
dc.publisher | Taylor & Francis | |
dc.relation.journal | Drug and Chemical Toxicology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Chemistry | |
dc.subject | Pharmacology & pharmacy | |
dc.subject | Micronucleus | |
dc.subject | Chromosome aberration assay | |
dc.subject | Naringin | |
dc.subject | Chemotherapeutic/radiomimetic agent | |
dc.subject | Bleomycin | |
dc.subject | Flavonoid | |
dc.subject | Radical scavenging activity | |
dc.subject | Antioxidant properties | |
dc.subject | Hydrogen-peroxide | |
dc.subject | Dna-damage | |
dc.subject | Cells | |
dc.subject | Rats | |
dc.subject | Cytotoxicity | |
dc.subject | Mechanisms | |
dc.subject | Flavonoids | |
dc.subject | Rutin | |
dc.subject | Toxicology | |
dc.subject.emtree | Aurantiin | |
dc.subject.emtree | Bleomycin | |
dc.subject.emtree | Antimutagenic agent | |
dc.subject.emtree | Aurantiin | |
dc.subject.emtree | Bleomycin | |
dc.subject.emtree | Flavanone derivative | |
dc.subject.emtree | Adult | |
dc.subject.emtree | Anti genotoxic activity | |
dc.subject.emtree | Article | |
dc.subject.emtree | Cell protection | |
dc.subject.emtree | Chromosome aberration | |
dc.subject.emtree | Chromosome aberration assay | |
dc.subject.emtree | Concentration response | |
dc.subject.emtree | Controlled study | |
dc.subject.emtree | DNA damage | |
dc.subject.emtree | Drug activity | |
dc.subject.emtree | Drug efficacy | |
dc.subject.emtree | Female | |
dc.subject.emtree | Genetic toxicology | |
dc.subject.emtree | Genotoxicity | |
dc.subject.emtree | Genotoxicity assay | |
dc.subject.emtree | Human | |
dc.subject.emtree | Human cell | |
dc.subject.emtree | In vitro study | |
dc.subject.emtree | Lymphocyte culture | |
dc.subject.emtree | Lymphocytotoxicity | |
dc.subject.emtree | Male | |
dc.subject.emtree | Micronucleus | |
dc.subject.emtree | Micronucleus test | |
dc.subject.emtree | Normal human | |
dc.subject.emtree | Adolescent | |
dc.subject.emtree | Cell culture | |
dc.subject.emtree | Cell culture technique | |
dc.subject.emtree | Chemically induced | |
dc.subject.emtree | DNA damage | |
dc.subject.emtree | Dose response | |
dc.subject.emtree | Drug effects | |
dc.subject.emtree | Lymphocyte | |
dc.subject.emtree | Ultrastructure | |
dc.subject.emtree | Young adult | |
dc.subject.mesh | Adolescent | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Antimutagenic agents | |
dc.subject.mesh | Bleomycin | |
dc.subject.mesh | Cell culture techniques | |
dc.subject.mesh | Cells, cultured | |
dc.subject.mesh | DNA damage | |
dc.subject.mesh | Dose-response relationship, drug | |
dc.subject.mesh | Female | |
dc.subject.mesh | Flavanones | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Lymphocytes | |
dc.subject.mesh | Male | |
dc.subject.mesh | Micronuclei, chromosome-defective | |
dc.subject.mesh | Young adult | |
dc.subject.scopus | Bleomycin; Streptomyces Verticillus; DNA | |
dc.subject.wos | Chemistry, multidisciplinary | |
dc.subject.wos | Pharmacology & pharmacy | |
dc.subject.wos | Toxicology | |
dc.title | Anti-genotoxic effect of naringin against bleomycin-induced genomic damage in human lymphocytes in vitro | |
dc.type | Article | |
dc.wos.quartile | Q3 | |
dspace.entity.type | Publication | |
local.contributor.department | Fen Edebiyat Fakültesi/Biyoloji Bölümü/Hücre Kültürü ve Genetik Toksikoloji Laboratuvarı | |
local.indexed.at | Scopus | |
local.indexed.at | WOS |
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