Publication:
Estimation of pulmonary arterial wave reflection by echo-doppler: A preliminary study in dogs with experimentally-induced acute pulmonary embolism

dc.contributor.authorYoshida, Tomohiko
dc.contributor.authorUejima, Tokuhisa
dc.contributor.authorKomeda, Syunta
dc.contributor.authorMatsuura, Katsuhiro
dc.contributor.authorUemura, Akiko
dc.contributor.authorHayama, Hiromasa
dc.contributor.authorYamashita, Takeshi
dc.contributor.authorTanaka, Ryou
dc.contributor.buuauthorYilmaz, Zeki
dc.contributor.buuauthorYILMAZ, ZEKİ
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.orcid0000-0003-4311-9311
dc.contributor.orcid0000-0002-6047-2865
dc.contributor.orcid0000-0003-2671-5074
dc.contributor.orcid0000-0001-6702-7150
dc.contributor.orcid0000-0002-2544-8464
dc.contributor.orcid0000-0001-9836-0749
dc.contributor.orcid0000-0001-9948-6490
dc.contributor.researcheridHQY-9709-2023
dc.contributor.researcheridCAH-7393-2022
dc.contributor.researcheridAHB-6165-2022
dc.contributor.researcheridA-9637-2008
dc.contributor.researcheridM-3078-2019
dc.date.accessioned2024-06-28T11:36:12Z
dc.date.available2024-06-28T11:36:12Z
dc.date.issued2021-12-08
dc.description.abstractBackground: Pulmonary arterial (PA) wave reflection provides additional information for assessing right ventricular afterload, but its applications is hampered by the need for invasive pressure and flow measurements. We tested the hypothesis that PA pressure and flow waveforms estimated by Doppler echocardiography could be used to quantify PA wave reflection.Methods: Doppler echocardiographic images of tricuspid regurgitation and right ventricular outflow tract flow used to estimate PA pressure and flow waveforms were acquired simultaneously with direct measurements with a dual sensor-tipped catheter under various hemodynamic conditions in a canine model of pulmonary hypertension (n = 8). Wave separation analysis was performed on echo-Doppler derived as well as catheter derived waveforms to separate PA pressure into forward (Pf) and backward (Pb) pressures and derive wave reflection coefficient (RC) defined as the ratio of peak Pb to peak Pf.Results: Wave reflection indices by echo-Doppler agreed well with corresponding indices by catheter (Pb: mean difference = 0.4 mmHg, 95% limits of agreement = -4.3 to 5.0 mmHg; RC: bias = 0.13, 95% limits of agreement = -0.25 to 0.26). RC correlated negatively with PA compliance.Conclusion: This echo-Doppler method yields reasonable measurement of reflected wave in the pulmonary circulation, paving the way to a more integrative assessment of pulmonary hemodynamics in the clinical setting.
dc.identifier.doi10.3389/fphys.2021.752550
dc.identifier.urihttps://doi.org/10.3389/fphys.2021.752550
dc.identifier.urihttps://hdl.handle.net/11452/42593
dc.identifier.volume12
dc.identifier.wos000732722900001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.journalFrontiers In Physiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectVascular-resistance
dc.subjectHypertension
dc.subjectPressure
dc.subjectTime
dc.subjectEchocardiography
dc.subjectDiagnosis
dc.subjectEnvelope
dc.subjectFraction
dc.subjectShape
dc.subjectPulmonary hypertension
dc.subjectWave separation analysis
dc.subjectWave reflection
dc.subjectDoppler echocardiography
dc.subjectWave intensity analysis
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectPhysiology
dc.subjectPhysiology
dc.titleEstimation of pulmonary arterial wave reflection by echo-doppler: A preliminary study in dogs with experimentally-induced acute pulmonary embolism
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi
relation.isAuthorOfPublicationf5c45ca8-95ff-4f54-8b7d-67fa0acfe53f
relation.isAuthorOfPublication.latestForDiscoveryf5c45ca8-95ff-4f54-8b7d-67fa0acfe53f

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