Publication:
Vasorelaxant effects of biochemical constituents of various medicinal plants and their benefits in diabetes

dc.contributor.authorDemirel, Sadettin
dc.contributor.buuauthorDEMİREL, SADETTİN
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFizyoloji Anabilim Dalı
dc.contributor.researcheridAAH-3460-2021
dc.date.accessioned2025-01-17T05:46:03Z
dc.date.available2025-01-17T05:46:03Z
dc.date.issued2024-06-15
dc.description.abstractEndothelial function plays a pivotal role in cardiovascular health, and dysfunction in this context diminishes vasorelaxation concomitant with endothelial activity. The nitric oxide-cyclic guanosine monophosphate pathway, prostacyclin-cyclic adenosine monophosphate pathway, inhibition of phosphodiesterase, and the opening of potassium channels, coupled with the reduction of calcium levels in the cell, constitute critical mechanisms governing vasorelaxation. Cardiovascular disease stands as a significant contributor to morbidity and mortality among individuals with diabetes, with adults afflicted by diabetes exhibiting a heightened cardiovascular risk compared to their non-diabetic counterparts. A plethora of medicinal plants, characterized by potent pharmacological effects and minimal side effects, holds promise in addressing these concerns. In this review, we delineate various medicinal plants and their respective biochemical constituents, showcasing concurrent vasorelaxant and anti-diabetic activities.
dc.identifier.doi10.4239/wjd.v15.i6.1122
dc.identifier.eissn1948-9358
dc.identifier.issue6
dc.identifier.urihttps://doi.org/10.4239/wjd.v15.i6.1122
dc.identifier.urihttps://www.wjgnet.com/1948-9358/full/v15/i6/1122.htm
dc.identifier.urihttps://pmc.ncbi.nlm.nih.gov/articles/PMC11229960/
dc.identifier.urihttps://hdl.handle.net/11452/49524
dc.identifier.volume15
dc.identifier.wos001272220800002
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherBaishideng Publishing
dc.relation.journalWorld Journal of Diabetes
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlpha-glucosidase activity
dc.subjectTyrosine-phosphatase 1b
dc.subjectMorus-bombycis koidzumi
dc.subjectArtemisia-herba-alba
dc.subjectRat thoracic aorta
dc.subjectNitric-oxide
dc.subjectEthanol extract
dc.subjectLeaf extract
dc.subjectVascular relaxation
dc.subjectBlood-glucose
dc.subjectMedicinal plants
dc.subjectVasorelaxation
dc.subjectEndothelium
dc.subjectDiabetes
dc.subjectAnti-diabetic
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectEndocrinology & metabolism
dc.titleVasorelaxant effects of biochemical constituents of various medicinal plants and their benefits in diabetes
dc.typeReview
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Fizyoloji Anabilim Dalı
local.indexed.atWOS
relation.isAuthorOfPublicationbf421fa5-e949-4453-b2b2-c4a9df1be392
relation.isAuthorOfPublication.latestForDiscoverybf421fa5-e949-4453-b2b2-c4a9df1be392

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