Publication:
Central choline suppresses plasma renin response to graded haemorrhage in rats

dc.contributor.buuauthorIşbil Büyükcoşkun, Naciye
dc.contributor.buuauthorİlçöl, Yeşim Özarda
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.buuauthorHamurtekin, Emre
dc.contributor.buuauthorÖzlük, Kasım
dc.contributor.buuauthorUlus, Ismail Hakki
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentKlinik Farmakoloji Ana Bilim Dalı
dc.contributor.departmentFizyoloji Ana Bilim Dalı
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.orcid0000-0003-2918-5064
dc.contributor.researcheridAAL-8873-2021
dc.contributor.researcheridM-9071-2019
dc.contributor.researcheridD-5340-2015
dc.contributor.researcheridAAH-1692-2021
dc.contributor.scopusid55665951400
dc.contributor.scopusid35741320500
dc.contributor.scopusid8872816100
dc.contributor.scopusid8717648500
dc.contributor.scopusid6602676331
dc.contributor.scopusid7004271086
dc.date.accessioned2024-03-08T10:27:13Z
dc.date.available2024-03-08T10:27:13Z
dc.date.issued2008-10
dc.description.abstract1. Central administration of choline increases blood pressure in normotensive and hypotensive states by increasing plasma concentrations of vasopressin and catecholamines. We hypothesized that choline could also modulate the renin-angiotensin pathway, the third main pressor system in the body. 2. Plasma renin activity (PRA), which serves as an index of the function of the peripheral renin-angiotensin system, was determined in rats subjected to graded haemorrhage following central choline administration. 3. Intracerebroventricular (i.c.v.) injection of choline (12.5-150 mu g), a precursor of the neurotransmitter acetylcholine (ACh), inhibited the increase in PRA in rats subjected to graded haemorrhage by sequential removal of 0.55 mL blood/100 g bodyweight. Choline, in the range 50-150 mu g, increased blood pressure. 4. Intraperitoneal (i.p.) administration of 150 mu g choline failed to alter blood pressure and plasma renin responses to graded haemorrhage. Administration of a higher dose (90 mg/kg, i.p.) of choline decreased blood pressure and enhanced PRA in the first two blood samples obtained during the graded haemorrhage. Physostigmine (10 mu g, i.c.v.), ACh (10 mu g, i.c.v.), carbamylcholine (10 mu g, i.c.v.) and cytidine 5'-diphosphocholine (CDP-choline; 250 mu g, i.c.v.) increased blood pressure and attenuated plasma renin responses to graded haemorrhage. 5. Inhibition of PRA by i.c.v. choline was abolished by i.c.v. pretreatment with mecamylamine (50 mu g), but not atropine (10 mu g). Blood pressure responses to choline (150 mu g) were attenuated by pretreatment with both mecamylamine and atropine. 6. Inhibition of PRA in response to central choline administration was associated with enhanced plasma vasopressin and catecholamine responses to graded haemorrhage. Pretreatment of rats with a vasopressin antagonist reversed central choline-induced inhibition of plasma renin responses to graded haemorrhage without altering the blood pressure response. 7. In conclusion, central administration of choline inhibits the plasma renin response to graded haemorrhage. Nicotinic receptor activation and an increase in plasma vasopressin appear to be involved in this effect.
dc.identifier.citationİşbil B. N. vd. (2008). "Central choline suppresses plasma renin response to graded haemorrhage in rats". Clinical and Experimental Pharmacology and Physiology, 35(9), 1023-1031.
dc.identifier.endpage1031
dc.identifier.issn1440-1681
dc.identifier.issue9
dc.identifier.pubmed18518880
dc.identifier.scopus2-s2.0-48749123356
dc.identifier.startpage1023
dc.identifier.urihttps://doi.org/10.1111/j.1440-1681.2008.04978.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1440-1681.2008.04978.x
dc.identifier.urihttps://hdl.handle.net/11452/40293
dc.identifier.volume35
dc.identifier.wos000258153900007
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWiley
dc.relation.journalClinical and Experimental Pharmacology and Physiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcetylcholine
dc.subjectBlood pressure
dc.subjectCatecholamine
dc.subjectCholine
dc.subjectGraded haemorrhage
dc.subjectIntracerebroventricular
dc.subjectPlasma renin activity
dc.subjectVasopressin
dc.subjectNicotinic acetylcholine-receptors
dc.subjectAdrenal tyrosine-hydroxylase
dc.subjectInjected cdp-choline
dc.subjectBlood-pressure
dc.subjectConscious rats
dc.subjectIntracerebroventricular choline
dc.subjectReverses hypotension
dc.subjectSympathoadrenal system
dc.subjectHeart-rate
dc.subjectIncreases
dc.subject.emtreeAcetylcholine
dc.subject.emtreeAtropine
dc.subject.emtreeCarbachol
dc.subject.emtreeCatecholamine
dc.subject.emtreeCholine
dc.subject.emtreeCiticoline
dc.subject.emtreeMecamylamine
dc.subject.emtreeNeurotransmitter
dc.subject.emtreeNcotinic receptor
dc.subject.emtreePhysostigmine
dc.subject.emtreePropranolol
dc.subject.emtreeVasopressin
dc.subject.emtreeVasopressin antagonist
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeArticle
dc.subject.emtreeBleeding
dc.subject.emtreeBlood sampling
dc.subject.emtreeBlood vessel reactivity
dc.subject.emtreeCatecholamine blood level
dc.subject.emtreeControlled study
dc.subject.emtreeFemale
dc.subject.emtreeHypotension
dc.subject.emtreeNonhuman
dc.subject.emtreePlasma renin activity
dc.subject.emtreePressor response
dc.subject.emtreeRat
dc.subject.emtreeReceptor upregulation;
dc.subject.emtreeRenin angiotensin aldosterone system
dc.subject.emtreeVasopressin blood level
dc.subject.meshAnimals
dc.subject.meshAntihypertensive agents
dc.subject.meshBlood pressure
dc.subject.meshCarbachol
dc.subject.meshCholine
dc.subject.meshCholinergic agonists
dc.subject.meshCholinesterase inhibitors
dc.subject.meshCytidine Diphosphate choline
dc.subject.meshDose-Response Relationship, drug
dc.subject.meshDrug interactions
dc.subject.meshFemale
dc.subject.meshHemorrhage
dc.subject.meshInjections, intraventricular
dc.subject.meshMecamylamine
dc.subject.meshPeriodicity
dc.subject.meshPhysostigmine
dc.subject.meshRats
dc.subject.meshRats, wistar
dc.subject.meshRenin
dc.subject.meshRenin-angiotensin system
dc.subject.meshVasopressins
dc.subject.otherPharmacology & pharmacy
dc.subject.otherPhysiology
dc.subject.scopusCiticoline; Brain Ischemia; Glycerylphosphorylcholine
dc.subject.wosPharmacology & pharmacy
dc.subject.wosPhysiology
dc.titleCentral choline suppresses plasma renin response to graded haemorrhage in rats
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Fizyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Biyokimya Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Klinik Farmakoloji Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
İşbil_vd_2008.pdf
Size:
312.97 KB
Format:
Adobe Portable Document Format

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: