Publication:
High-grade and low-grade gliomas: Differentiation by using perfusion MR imaging

dc.contributor.authorHakyemez, Bahattin
dc.contributor.authorErgin, Nida
dc.contributor.authorUysal, Sibel
dc.contributor.authorAtahan, Safak
dc.contributor.buuauthorErdoğan, Cüneyt
dc.contributor.buuauthorErcan, Ilker
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentBiyoistatistik Ana Bilim Dalı
dc.contributor.departmentRadyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-2382-290X
dc.date.accessioned2021-06-30T10:22:50Z
dc.date.available2021-06-30T10:22:50Z
dc.date.issued2005
dc.description.abstractAIM: Relative cerebral blood volume (rCBV) is a commonly used perfusion magnetic resonance imaging (MRI) technique for the evaluation of tumour grade. Relative cerebral blood flow (rCBF) has been less studied. The goal of our study was to determine the usefulness of these parameters in evaluating the histopathotogical grade of the cerebral gliomas. METHODS: This study involved 33 patients (22 high-grade and 11 low-grade glioma cases). MRI was performed for all tumours by using a first-passage gadopentetate dimeglumine T2*-weighted gradient-echo single-shot echo-ptanar sequence followed by conventional MRI. The rCBV and rCBF were calculated by deconvolution of an arterial, input function. The rCBV and rCBF ratios of the lesions were obtained by dividing the values obtained from the normal white matter of the contralateral, hemisphere. For statistical analysis Mann-Whitney testing was carried out. A p value of less than 0.05 indicated a statistically significant difference. Receiver operating characteristic curve (ROC) analysis was performed to assess the relationship between the rCBV and rCBF ratios and grade of gliomas. Their cut-off value permitting discrimination was calculated. The correlation between rCBV and CBF ratios and glioma grade was assessed using Pearson correlation analysis. RESULTS: In high-grade gliomas, rCBV and rCBF ratios were measured as 6.50 +/- 4.29 and 3.32 +/- 11.87 (mean +/- SD), respectively. In low-grade gliomas, rCBV and rCBF ratios were 1.69 +/- 0.51 and 1.16 +/- 0.38, respectively. The rCBV and rCBF ratios for high-grade gliomas were statistically different from those of tow-grade gliomas (p < 0.001). The rCBV and CBF ratios were significantly matched with respect to grade, but difference between the two areas was not significant (ROC analysis, p > 0.05). The cut-off value was taken as 1.98 in the rCBV ratio and 1.25 in the rCBF ratio. There was a strong correlation between the rCBV and CBF ratios (Pearson correlation = 0.830, p < 0.05). CONCLUSION: Perfusion MRI is useful in the preoperative assessment of the histopathologicalal grade of gliomas; the rCBF ratio in addition to the rCBV ratio can be incorporated in MR perfusion analysis for the evaluation. (c) 2005 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
dc.identifier.citationHakyemez, B. vd. (2005). "High-grade and low-grade gliomas: Differentiation by using perfusion MR imaging". Clinical Radiology, 60(4), 493-502.
dc.identifier.endpage502
dc.identifier.issn0009-9260
dc.identifier.issue4
dc.identifier.pubmed15767107
dc.identifier.scopus2-s2.0-14844348436
dc.identifier.startpage493
dc.identifier.urihttps://doi.org/10.1016/j.crad.2004.09.009
dc.identifier.urihttp://hdl.handle.net/11452/20928
dc.identifier.volume60
dc.identifier.wos000228259900009
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherW B Saunders Co Ltd
dc.relation.collaborationSanayi
dc.relation.collaborationYurt içi
dc.relation.journalClinical Radiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBlood-volume maps
dc.subjectFlow
dc.subjectBrain-tumors
dc.subjectNeoplasms
dc.subjectBrain neoplasms
dc.subjectContrast enhancement
dc.subjectBlood flow
dc.subjectCerebral blood vessels
dc.subjectFlow dynamics
dc.subjectMagnetic resonance (MR)
dc.subjectRadiology, nuclear medicine & medical imaging
dc.subject.wosRadiology, nuclear medicine & medical imaging
dc.titleHigh-grade and low-grade gliomas: Differentiation by using perfusion MR imaging
dc.typeArticle
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Radyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Biyoistatistik Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atScopus

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