Publication:
Solid lipid nanoparticles in reversing the acquired tamoxifen-resistance

dc.contributor.authorEskiler, Gamze Güney
dc.contributor.buuauthorÇeçener, Gülşah
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorTunca, Berrin
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Biyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-3820-424X
dc.contributor.orcid0000-0001-7904-883X
dc.contributor.orcid0000-0002-1619-6680
dc.contributor.researcheridAAP-9988-2020
dc.contributor.researcheridAAH-1420-2021
dc.contributor.researcheridABI-6078-2020
dc.contributor.scopusid6508156530
dc.contributor.scopusid55665145000
dc.contributor.scopusid6602965754
dc.date.accessioned2023-09-19T11:33:33Z
dc.date.available2023-09-19T11:33:33Z
dc.date.issued2017
dc.descriptionBu çalışma, 22-24 Haziran, 2017 tarihlerinde Sinaia[Romanya]’da düzenlenen 6. IEEE International Conference on E-Health and Bioengineering (EHB) Kongresi‘nde bildiri olarak sunulmuştur.
dc.description.abstractThe anti-estrogen tamoxifen (Tam) is the most preferred option for patients with estrogen-receptor (ER)-positive breast cancer. However, multi-drug resistance (MDR) is a considerable clinical problem in the successful chemotherapeutic treatment. Members of the ATP-binding cassette (ABC) transporter family proteins play an important role in acquired drug resistance. Many studies have focused primarily on the clinical significance of P-gp (MDR1), BCRP and MRP1 members belong to ABC transporter superfamily on anticancer-drug resistance. Consequently, several strategies have been improved to overcome drug resistance. Nanoparticle drug delivery systems provide an increase in the intracellular concentration of the drugs as well as a reduction in toxicity of free-drug on healthy cells thanks to unique physical and biological properties. Solid lipid nanoparticles (SLNs) have been improved as an alternative colloidal drug delivery systems due to successful incorporation of both hydrophilic and hydrophobic compounds and their related benefits (controlled drug release, high entrapment efficiency and small size etc.) For this purpose, the aim of this study was to discuss the role of Tam-loaded solid lipid nanoparticles (SLNs) to overcome MDR and determine the ability of Tam-SLNs to induce apoptosis.
dc.description.sponsorshipIEEE
dc.description.sponsorshipIEEE EMB
dc.description.sponsorshipRomania Chapter
dc.description.sponsorshipRomanian Acad, Iasi Branch, Inst Comp Sci
dc.description.sponsorshipGrigore T Popa Univ Med & Pharmacy
dc.description.sponsorshipIEEE Romania Sect
dc.description.sponsorshipInst Informatica Teoretica
dc.description.sponsorshipESC Working Grp e Cardiol
dc.description.sponsorshipRomanian Soc Med Bioengineering
dc.description.sponsorshipGrigore T Popa Univ Med & Pharmacy
dc.description.sponsorshipFac Med Bioengineering
dc.description.sponsorshipIEEE EMC Romania Chapter
dc.identifier.citationEskiler, G. G. vd. (2017). ''Solid lipid nanoparticles in reversing the acquired tamoxifen-resistance''. E-Health and Bioengineering Conference, 2017 IEEE international conference on e-health and bioengineering conference (EHB), 177-180.
dc.identifier.endpage180
dc.identifier.isbn978-1-5386-0358-1
dc.identifier.issn2575-5137
dc.identifier.issn2575-5145
dc.identifier.scopus2-s2.0-85028523742
dc.identifier.startpage177
dc.identifier.urihttp://hdl.handle.net/11452/33902
dc.identifier.wos000445457500045
dc.indexed.wosCPCIS
dc.language.isoen
dc.publisherIEEE
dc.relation.bapOUAP(T)-2014/30
dc.relation.collaborationYurt içi
dc.relation.journalE-Health and Bioengineering Conference, 2017 IEEE international conference on e-health and bioengineering conference (EHB)
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectComputer science
dc.subjectEngineering
dc.subjectMedical informatics
dc.subjectBreast cancer
dc.subjectTamoxifen
dc.subjectMulti-drug resistance (MDR)
dc.subjectNanoparticle drug delivery systems
dc.subjectSolid lipid nanoparticles (SLNs)
dc.subjectOf-the-art
dc.subjectBreast-cancer
dc.subjectDrug-delivery
dc.subjectCell death
dc.subjectDiseases
dc.subjectDrug therapy
dc.subjectElectric resistance
dc.subjectHydrophobicity
dc.subjectNanoparticles
dc.subjectBreast cancer
dc.subjectDrug delivery system
dc.subjectMultidrug resistance
dc.subjectSolid lipid nanoparticles
dc.subjectTamoxifen
dc.subjectControlled drug delivery
dc.subject.scopusBreast Neoplasms; Aromatase Inhibitors; Estrogen Receptors
dc.subject.wosComputer science, interdisciplinary applications
dc.subject.wosEngineering, biomedical
dc.subject.wosMedical informatics
dc.titleSolid lipid nanoparticles in reversing the acquired tamoxifen-resistance
dc.typeProceedings Paper
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Biyoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

Files

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: