Publication:
Impact of menthol on oral nicotine consumption in female and male sprague dawley rats

dc.contributor.authorBağdaş, Deniz
dc.contributor.authorGül, Zülfiye
dc.contributor.authorScott, Michael M.
dc.contributor.authorTyndale, Rachel F.
dc.contributor.authorDamaj, M. Imad
dc.contributor.buuauthorCam, Betül
dc.contributor.buuauthorBüyükuysal, Levent
dc.contributor.buuauthorGürün, Mine Sibel
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmakoloji Ana Bilim Dalı
dc.contributor.researcheridAAH-1657-2021
dc.contributor.researcheridCGO-3719-2022
dc.contributor.researcheridDVX-8040-2022
dc.contributor.scopusid56427863700
dc.contributor.scopusid6602686612
dc.contributor.scopusid55664349700
dc.date.accessioned2023-01-30T08:46:11Z
dc.date.available2023-01-30T08:46:11Z
dc.date.issued2019-02-05
dc.description.abstractIntroduction: One of the preferable flavors in oral nicotine delivery systems is menthol which masks the harshness of tobacco. However, possible interactions between oral menthol and nicotine on intake and preference remain unclear. Therefore, we aimed to determine the impact of menthol on oral nicotine consumption. Methods: Adult Sprague Dawley female and male rats (n = 8 per group) were given a choice of water or drug solution by using two-bottle free choice paradigm for 2 weeks: vehicle (5% ethanol), nicotine (20 mg/L), menthol (1 g/L) and mentholated nicotine groups. At the end of the study, plasma nicotine levels were determined. Results: When rats were given a choice of nicotine or water, nicotine intake was similar between female and male rats. Menthol addition to nicotine solution significantly increased nicotine intake and preference in male but not female rats without a considerable effect on total fluid intake and body weight change in either sex. The average nicotine intake in male rats was 0.5 +/- 0.05 and 1.4 +/- 0.12 mg/kg/day for nicotine and menthol-nicotine combination (p <.05), respectively. The average nicotine intake in female rats was 0.6 +/- 0.05 and 0.6 +/- 0.03 mg/kg/day for nicotine and mentholnicotine combination (p >.05), respectively. Plasma nicotine levels were not significantly different between the groups in either male (nicotine group: 20.8 +/- 4.9, mentholated nicotine group: 31.9 +/- 3.2 ng/mL) or female (nicotine group: 24.0 +/- 3.3, mentholated nicotine group: 17.8 +/- 2.9 ng/mL) rats (p >.05). Conclusions: Menthol increases oral nicotine consumption in male, but not female, rats.
dc.description.sponsorshipCanada Research Chair in Pharmacogenomics
dc.description.sponsorshipTraining and Education Core of the National Institute on Drug Abuse of the National Institutes of Health (NIH) (P50DA036105)
dc.description.sponsorshipCenter for Tobacco Products of the US Food and Drug Administration
dc.description.sponsorshipCanadian Institutes of Health Research (FDN-154294)
dc.description.sponsorshipRat für Forschung und Technologieentwicklung
dc.identifier.citationBağdaş, D. vd. (2020). "Impact of menthol on oral nicotine consumption in female and male sprague dawley rats". Nicotine and Tobacco Research, 22(2), 196-203.
dc.identifier.endpage203
dc.identifier.issn1462-2203
dc.identifier.issn1469-994X
dc.identifier.issue2
dc.identifier.pubmed30753589
dc.identifier.scopus2-s2.0-85079060389
dc.identifier.startpage196
dc.identifier.urihttps://doi.org/10.1093/ntr/ntz019
dc.identifier.urihttps://academic.oup.com/ntr/article/22/2/196/5315480
dc.identifier.urihttp://hdl.handle.net/11452/30709
dc.identifier.volume22
dc.identifier.wos000546958300008
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherOxford University Press
dc.relation.bapKUAP-T 2016/15
dc.relation.collaborationYurt dışı
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalNicotine and Tobacco Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSubstance abuse
dc.subjectPublic, environmental & occupational health
dc.subjectSex-dependent manner
dc.subjectSmokeless tobacco
dc.subjectCigaratte-smoking
dc.subjectSensory neurons
dc.subjectUnited-States
dc.subjectUp-regulation
dc.subjectMetabolism
dc.subjectProducts
dc.subjectReceptor
dc.subjectSmokers
dc.subject.emtreeMenthol
dc.subject.emtreeNicotine
dc.subject.emtreeWater
dc.subject.emtreeFlavoring agent
dc.subject.emtreeMenthol
dc.subject.emtreeNicotine
dc.subject.emtreeAdult
dc.subject.emtreeAnimal experiment
dc.subject.emtreeArticle
dc.subject.emtreeBlood level
dc.subject.emtreeBody weight change
dc.subject.emtreeDecision making
dc.subject.emtreeFemale
dc.subject.emtreeFluid intake
dc.subject.emtreeMale
dc.subject.emtreeNonhuman
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.emtreeSex difference
dc.subject.emtreeSmokeless tobacco
dc.subject.emtreeSubstance use
dc.subject.emtreeAnimal
dc.subject.emtreeBlood
dc.subject.emtreeDrug effect
dc.subject.emtreePhysiology
dc.subject.emtreeSexual characteristics
dc.subject.emtreeSprague Dawley rat
dc.subject.emtreeTaste
dc.subject.meshAnimals
dc.subject.meshChoice behavior
dc.subject.meshFemale
dc.subject.meshFlavoring agents
dc.subject.meshMale
dc.subject.meshMenthol
dc.subject.meshNicotine
dc.subject.meshRats
dc.subject.meshRats, sprague-dawley
dc.subject.meshSex characteristics
dc.subject.meshTaste
dc.subject.scopusMenthol; Tobacco; Smoking
dc.subject.wosSubstance abuse
dc.subject.wosPublic, environmental & occupational health
dc.titleImpact of menthol on oral nicotine consumption in female and male sprague dawley rats
dc.typeArticle
dc.wos.quartileQ1
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Farmakoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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