Publication:
Management of patients with coexisting obstructive sleep apnea and laryngopharyngeal reflux disease

dc.contributor.authorErişen, Levent
dc.contributor.buuauthorEryılmaz, Aylin
dc.contributor.buuauthorDemir, Uygar Levent
dc.contributor.buuauthorKasapoǧlu, Fikret
dc.contributor.buuauthorÖzmen, Ömer Afşin
dc.contributor.buuauthorUrsavaş, Ahmet
dc.contributor.buuauthorKıyıcı, Murat
dc.contributor.buuauthorHızalan, İbrahim
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentGöğüs Hastalıkları Ana Bilim Dalı
dc.contributor.departmentKulak Burun Boğaz Ana Bilim Dalı
dc.contributor.departmentGastroenteroloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-9698-0546
dc.contributor.orcid0000-0002-3208-6211
dc.contributor.researcheridA-1452-2019
dc.contributor.researcheridAAI-4213-2021
dc.contributor.researcheridAAI-3877-2021
dc.contributor.researcheridAAI-3169-2021
dc.contributor.scopusid56305841300
dc.contributor.scopusid56868421800
dc.contributor.scopusid56254721200
dc.contributor.scopusid55407733900
dc.contributor.scopusid8329319900
dc.contributor.scopusid6507627491
dc.contributor.scopusid6506478628
dc.date.accessioned2022-04-12T05:30:09Z
dc.date.available2022-04-12T05:30:09Z
dc.date.issued2012-12
dc.description.abstractObstructive sleep apnea syndrome (OSAS) and Laryngopharyngeal reflux disease (LPR) are both common health problems causing severe morbidity. Since they have similar risk factors, the prevalence of LPR among patients with OSAS is higher compared with general population. However, there exist only a few studies showing the potential causal relation between LPR and OSAS. The aim of this study was to evaluate the coexistence between OSAS and LPR and to determine whether the therapy of OSAS alters LPR parameters and vice versa. In this study, 44 patients underwent double probed 24 h pH monitoring simultaneously with polysomnography due to the complaints of obstructive sleep apnea and reflux. Twenty of those 44 patients were diagnosed with both OSAS and LPR. Among those patients, 10 patients with mild to moderate OSAS were given only LPR treatment for 3 months. The remaining 10 patients who had severe OSAS underwent CPAP treatment for 3 months. After the end of treatment, all patients were reevaluated with double probed 24 h pH monitoring simultaneously with PSG. Moreover, the patients were evaluated subjectively by Epworth Sleepiness Scale (ESS), snoring Visual Analogue Scale (VAS), Reflux Symptom Index (RSI), and Reflux Finding Score (RFS). The results of this study revealed that OSAS and LPR coexist frequently. LPR treatment did not improve the polysomnographic parameters, but significantly reduced ESS and snoring VAS (p = 0.02 and p = 0.007, respectively). Although the CPAP treatment significantly improved subjective parameters of reflux, such as RSI and RFS (p = 0.016 for both), there was no significant improvement in objective parameters of 24-h pH monitoring. We concluded that since there is a high frequency of coexistence between LPR and OSAS, all patients with OSAS should also be queried for LPR symptoms. In addition, more in-depth and comprehensive research is required to elucidate the association between OSAS and LPR.
dc.identifier.citationEryılmaz, A. vd. (2012). "Management of patients with coexisting obstructive sleep apnea and laryngopharyngeal reflux disease". European Archives of Oto-Rhino-Laryngology, 269(12), 2575-2580.
dc.identifier.endpage2580
dc.identifier.issn0937-4477
dc.identifier.issue12
dc.identifier.pubmed22707319
dc.identifier.scopus2-s2.0-84871295293
dc.identifier.startpage2575
dc.identifier.urihttps://doi.org/10.1007/s00405-012-2062-z
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs00405-012-2062-z
dc.identifier.urihttp://hdl.handle.net/11452/25711
dc.identifier.volume269
dc.identifier.wos000310810400019
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSpringer
dc.relation.collaborationYurt içi
dc.relation.journalEuropean Archives of Oto-Rhino-Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOtorhinolaryngology
dc.subjectObstructive sleep apnea syndrome
dc.subjectLaryngopharyngeal reflux
dc.subjectContinuous positive airway pressure
dc.subjectPolysomnography
dc.subjectDouble probed 24 h pH monitoring
dc.subjectPositive airway pressure
dc.subjectSymptomatic gastroesophageal-reflux
dc.subjectProximal probe
dc.subjectPantoprazole
dc.subjectReliability
dc.subjectValidity
dc.subjectAdults
dc.subjectAcid
dc.subjectGerd
dc.subjectMen
dc.subject.emtreeApnea hypopnea index
dc.subject.emtreeArticle
dc.subject.emtreeClinical article
dc.subject.emtreeElectroencephalography
dc.subject.emtreeEsophageal pH monitoring
dc.subject.emtreeHuman
dc.subject.emtreeLaryngopharyngeal reflux
dc.subject.emtreePolysomnography
dc.subject.emtreePositive end expiratory pressure
dc.subject.emtreePriority journal
dc.subject.emtreeSleep disordered breathing
dc.subject.emtreeVisual analog scale
dc.subject.meshAdult
dc.subject.meshAnti-ulcer agents
dc.subject.meshContinuous positive airway pressure
dc.subject.meshEsophageal pH monitoring
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLaryngopharyngeal reflux
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshPolysomnography
dc.subject.meshProton pump inhibitors
dc.subject.meshSeverity of illness index
dc.subject.meshSleep apnea, obstructive
dc.subject.scopusGastroesophageal Reflux; Hiatus Hernia; Esophagitis
dc.subject.wosOtorhinolaryngology
dc.titleManagement of patients with coexisting obstructive sleep apnea and laryngopharyngeal reflux disease
dc.typeArticle
dc.wos.quartileQ2
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Kulak Burun Boğaz Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Göğüs Hastalıkları Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Gastroenteroloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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