Publication:
Evaluation of serum creatine kinase in ectopic pregnancy with reference to tubal status and histopathology

dc.contributor.buuauthorDevelioğlu, Osman H.
dc.contributor.buuauthorAskallı, Cenk
dc.contributor.buuauthorUncu, Gürkan
dc.contributor.buuauthorŞamlı, Billur
dc.contributor.buuauthorDaragenli, Ömer
dc.contributor.departmentTıp Fakültesi
dc.date.accessioned2021-08-31T11:21:20Z
dc.date.available2021-08-31T11:21:20Z
dc.date.issued2002-02
dc.description.abstractObjective To study the value of creatine kinase in ectopic pregnancy with reference to tubal histopathology. Design Prospective controlled study. Setting Academic tertiary-care institution. Population Thirty-two women with ectopic pregnancy and 20 controls with intrauterine pregnancies. Methods Creatine kinase and beta-hCG levels were measured on admission. Ectopic pregnancies were removed at surgery and examined histologically. Main outcome measures Tubal localisation and integrity of ectopic pregnancies as judged at surgery and later histologically, and placental growth patterns in unruptured ectopic pregnancies classified as intraluminal, extraluminal or mixed as determined histologically. Results Creatine kinase levels were higher in isthmic than ampullary ectopic pregnancies (P = 0.011), and higher in ruptured than in unruptured cases (P = 0.003) and normal pregnancies (P < 0.0001). A creatine kinase value >120iu/L was 65% sensitive and 87% specific in discriminating ruptured from unruptured ectopic pregnancies. Creatine kinase levels were above this cutoff in two of five unruptured ampullary ectopic pregnancies with invasive trophoblastic growth, yet in none of nine cases with intraluminally confined placentation (P = 0.04). Creatine kinase was positively correlated with gestational age in ruptured (P = 0.007), but not in unruptured ectopic pregnancies or normal pregnancies. Conclusions Serum creatine kinase may help in discriminating ruptured from unruptured ectopic pregnancies, while it is not useful for the primary diagnosis of ectopic pregnancy. An increase in creatine kinase levels accompanying muscular damage in ectopic pregnancy probably antedates tubal rupture, and may be related to trophoblastic growth patterns.
dc.identifier.citationDevelioğlu, O. H. vd. (2002). "Evaluation of serum creatine kinase in ectopic pregnancy with reference to tubal status and histopathology". Bjog-An International Journal of Obstetrics snd Gynaecology, 109(2), 121-128.
dc.identifier.endpage128
dc.identifier.issn1470-0328
dc.identifier.issue2
dc.identifier.pubmed11888094
dc.identifier.scopus2-s2.0-0036484528
dc.identifier.startpage121
dc.identifier.urihttps://doi.org/10.1111/j.1471-0528.2002.00243.x
dc.identifier.urihttps://obgyn.onlinelibrary.wiley.com/doi/10.1111/j.1471-0528.2002.00243.x
dc.identifier.urihttp://hdl.handle.net/11452/21581
dc.identifier.volume109
dc.identifier.wos000179219900007
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWiley
dc.relation.journalBjog- An International Journal of Obstetrics and Gynaecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiagnosis
dc.subjectObstetrics & Gynecology
dc.subject.scopusEctopic Pregnancy; Salpingostomy; Chorionic Gonadotropins
dc.subject.wosObstetrics & gynecology
dc.titleEvaluation of serum creatine kinase in ectopic pregnancy with reference to tubal status and histopathology
dc.typeArticle
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi
local.indexed.atPubMed
local.indexed.atWOS

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