Publication:
Characterization of invasive Neisseria meningitidis isolates recovered from children in Turkey during a period of increased serogroup B disease, 2013-2017

dc.contributor.authorCeyhan, Mehmet
dc.contributor.authorÖzsürekçi, Yasemin
dc.contributor.authorLucidarme, Jay
dc.contributor.authorBorrow, Ray
dc.contributor.authorGürler, Nezahat
dc.contributor.authorEmiroğlu, Melike Keser
dc.contributor.authorÖz, Fatma Nur
dc.contributor.authorKurugöl, Zafer
dc.contributor.authorÇelik, Ümit
dc.contributor.authorParlakay, Aslınur Özkaya
dc.contributor.authorDinleyici, Ener Çağrı
dc.contributor.authorKarbuz, Adem
dc.contributor.authorBelet, Nursen
dc.contributor.authorDevrim, İlker
dc.contributor.authorGülfidan, Gamze
dc.contributor.authorGündeşlioğlu, Özlem
dc.contributor.authorYücel, Mihriban
dc.contributor.authorUlusoy, Emel
dc.contributor.authorCengiz, Ali Bülent
dc.contributor.buuauthorÇelebi, Solmaz
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentÇocuk Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.contributor.researcheridENK-4130-2022
dc.contributor.scopusid7006095295
dc.date.accessioned2023-10-23T11:33:05Z
dc.date.available2023-10-23T11:33:05Z
dc.date.issued2020-04-23
dc.description.abstractDiverse Neisseria meningitidis strains belonging to various serogroups and clonal complexes cause epidemic and endemic life-threatening disease worldwide. This study aimed to investigate the genetic diversity of recent invasive meningococci in Turkey with respect to multilocus sequence type (MLST) and also meningococcal serogroup B (MenB) vaccine antigens to enable assessment of potential MenB strain coverage using the genetic Meningococcal Antigen Typing System (gMATS). Fifty-four isolates, representing 37.5% of all pediatric (ages 0-18 years) invasive meningococcal disease cases in Turkey from January 2013 to December 2017, underwent genome sequence analysis. Thirty-six (66.7%) isolates were MenB, 10 (18.5%) were serogroup W (MenW), 4 (7.4%) were serogroup A (MenA), 3 (5.6%) were serogroup Y (MenY) and 1 (1.8%) was serogroup X (MenX). The MenB isolates were diverse with cc35 (19.4%), cc41/44 (19.4%) and cc32 (13.8%) as the most prevalent clonal complexes. The MenW isolates (n = 10) comprised cc11 (n = 5), ST-2754 (cc-unassigned; n = 4) and cc22 (n = 1). gMATS was indicative of high 4CMenB coverage (72.2-79.1%) of Turkish invasive MenB strains from pediatric patients. Strain coverage of several clonal complexes differed from that seen elsewhere in Europe highlighting the importance of performing local assessments and also the use of phenotypic methods, i.e. MATS, where possible. All of the isolates possessed in-frame fhbp alleles and so were potentially covered by MenB-fHbp. Continued surveillance is essential to guide recommendations for current and future vaccines as well as understanding changes in epidemiology.
dc.description.sponsorshipWellcome Trust
dc.description.sponsorshipEuropean Union (EU)
dc.identifier.citationCeyhan, M. vd. (2020). "Characterization of invasive Neisseria meningitidis isolates recovered from children in Turkey during a period of increased serogroup B disease, 2013-2017". Vaccine, 38(19), 3545-3552.
dc.identifier.endpage3552
dc.identifier.issn0264-410X
dc.identifier.issn1873-2518
dc.identifier.issue19
dc.identifier.pubmed32199701
dc.identifier.scopus2-s2.0-85082693331
dc.identifier.startpage3545
dc.identifier.urihttps://doi.org/10.1016/j.vaccine.2020.03.024
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0264410X20303777
dc.identifier.urihttp://hdl.handle.net/11452/34523
dc.identifier.volume38
dc.identifier.wos000525318100007
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalVaccine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectImmunology
dc.subjectResearch & experimental medicine
dc.subjectNeisseria meningitidis
dc.subjectInvasive meningococcal disease (IMD)
dc.subjectGenotyping
dc.subjectMolecular epidemiology
dc.subjectTurkey
dc.subjectW135 meningococcal disease
dc.subjectStreptococcus-pneumoniae
dc.subjectHaemophilus-influenzae
dc.subjectStrain coverage
dc.subjectStrain coverage
dc.subjectEpidemiology
dc.subjectEmergence
dc.subjectRecommendations
dc.subjectMortality
dc.subjectOutbreak
dc.subjectComplex
dc.subject.emtreeComplement factor H
dc.subject.emtreeMeningococcus vaccine
dc.subject.emtreeBacterial antigen
dc.subject.emtreeMeningococcus vaccine
dc.subject.emtreeAdolescent
dc.subject.emtreeAdult
dc.subject.emtreeAllele
dc.subject.emtreeArticle
dc.subject.emtreeBacterial genome
dc.subject.emtreeBacterial strain
dc.subject.emtreeBacterium examination
dc.subject.emtreeBacterium isolate
dc.subject.emtreeChild
dc.subject.emtreeGenet (clone)
dc.subject.emtreeGenetic variability
dc.subject.emtreeGenotyping technique
dc.subject.emtreeHuman
dc.subject.emtreeInfant
dc.subject.emtreeInvasive species
dc.subject.emtreeMeningococcosis
dc.subject.emtreeMolecular epidemiology
dc.subject.emtreeMultilocus sequence typing
dc.subject.emtreeNeisseria meningitidis
dc.subject.emtreeNonhuman
dc.subject.emtreePediatric patient
dc.subject.emtreePriority journal
dc.subject.emtreeSequence analysis
dc.subject.emtreeSerotype
dc.subject.emtreeTurkey (republic)
dc.subject.emtreeVaccination coverage
dc.subject.emtreeEurope
dc.subject.emtreeGenetics
dc.subject.emtreeMeningococcosis
dc.subject.emtreeNewborn
dc.subject.emtreePreschool child
dc.subject.emtreeTurkey (bird)
dc.subject.meshAdolescent
dc.subject.meshAntigens, bacterial
dc.subject.meshChild
dc.subject.meshChild, preschool
dc.subject.meshEurope
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshInfant, newborn
dc.subject.meshMeningococcal infections
dc.subject.meshMeningococcal vaccines
dc.subject.meshMultilocus sequence typing
dc.subject.meshNeisseria meningitidis
dc.subject.meshNeisseria meningitidis, serogroup B
dc.subject.meshSerogroup
dc.subject.meshTurkey
dc.subject.scopusMeningococcosis; Serotype; Neisseria meningitidis
dc.subject.wosImmunology
dc.subject.wosMedicine, research & experimental
dc.titleCharacterization of invasive Neisseria meningitidis isolates recovered from children in Turkey during a period of increased serogroup B disease, 2013-2017
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Çocuk Enfeksiyon Hastalıkları Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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