Experimental models used in neurosurgery practice and selection of an appropriate model

Abstract

The role of animal experiments in the progress of medicine and its current stage has a significant effect. Most of the research in the medical and veterinary fields requires the use of experimental animals. It is a possible fact that the next experimental studies will be realized with the contribution of animal experiments. On the other hand, since humans cannot be included in experimental studies due to ethical reasons, the use of animals is mandatory. There are many models in which experimental animals are used. However, the use of experimental animals also brings some disadvantages. Experimental animals cannot be used randomly for scientific or any other purpose. Even if the experimental protocol was carried out properly, it will in-validate the obtained data if the appropriate experimental model is not chosen for the study. If the wrong experimental model is chosen, it will result in both economic and time loss. For these reasons, how and which model will be applied in internal and surgical branches in experimental studies and subject selection constitute an important problem. Choosing a suitable subject for the study increases the applicability of the studies and ensures that positive results can be obtained. In our ar-ticle, we planned to compile the experimental models applied in the lit-erature with different aspects including their advantages and disadvantages and to provide the practitioner with ease of choice.