Treatment with a combination of bosentan and sildenafil allows for successful liver transplantation in a patient with portopulmonary hypertension

Yayın:
Treatment with a combination of bosentan and sildenafil allows for successful liver transplantation in a patient with portopulmonary hypertension

dc.contributor.buuauthor	Sağ, Saim
dc.contributor.buuauthor	Yeşilbursa, Dilek
dc.contributor.buuauthor	Güllülü, Sümeyye
dc.contributor.department	Tıp Fakültesi
dc.contributor.department	Kardiyoloji Ana Bilim Dalı
dc.contributor.orcid	0000-0001-8404-8252
dc.contributor.researcherid	AAW-9185-2020
dc.contributor.scopusid	12140008100
dc.contributor.scopusid	36658194500
dc.contributor.scopusid	57204660708
dc.date.accessioned	2024-02-13T07:06:36Z
dc.date.available	2024-02-13T07:06:36Z
dc.date.issued	2014-06-19
dc.description.abstract	Pulmonary arterial hypertension (PAH) that occurs in the setting of cirrhosis and portal hypertension is referred to as portopulmonary hypertension (PPHTN). Liver transplantation (LTx) is curative, but the presence of moderate-to-severe PPHTN may be a contraindication for transplantation because of the elevated risk of peri-and post-transplantation morbidity and mortality. We report a successful liver transplantation in a patient with liver cirrhosis after treatment of moderate-to-severe PPHTN with a combination of the dual endothelin receptor antagonist bosentan and the specific phosphodiesterase-5 inhibitor sildenafil.
dc.identifier.citation	Sağ, S. vd. (2014). "Treatment with a combination of bosentan and sildenafil allows for successful liver transplantation in a patient with portopulmonary hypertension". Türk Gastroenteroloji Dergisi, 25(4), 429-432.
dc.identifier.doi	10.5152/tjg.2014.7688
dc.identifier.endpage	432
dc.identifier.issn	1300-4948
dc.identifier.issue	4
dc.identifier.pubmed	25254528
dc.identifier.scopus	2-s2.0-84908146008
dc.identifier.startpage	429
dc.identifier.uri	https://turkjgastroenterol.org/en/treatment-with-a-combination-of-bosentan-and-sildenafil-allows-for-successful-liver-transplantation-in-a-patient-with-portopulmonary-hypertension-134399%5C
dc.identifier.uri	https://hdl.handle.net/11452/39651
dc.identifier.volume	25
dc.identifier.wos	000345025900016
dc.indexed.wos	SCIE
dc.language.iso	en
dc.publisher	AVES
dc.relation.journal	Türk Gastroenteroloji Dergisi
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	Bosentan
dc.subject	Sildenafil
dc.subject	Cirrhosis
dc.subject	Portopulmonary hypertension
dc.subject	Liver transplantation
dc.subject	Pulmonary-hypertension
dc.subject	Hemodynamics
dc.subject	Therapy
dc.subject	Iloprost
dc.subject	Moderate
dc.subject	Gastroenterology & hepatology
dc.subject.emtree	Adult
dc.subject.emtree	Article
dc.subject.emtree	Ascites
dc.subject.emtree	Case report
dc.subject.emtree	Disease severity
dc.subject.emtree	Drug dose increase
dc.subject.emtree	Drug megadose
dc.subject.emtree	Esophagus varices bleeding
dc.subject.emtree	Hepatic encephalopathy
dc.subject.emtree	Hepatitis B.
dc.subject.emtree	Human
dc.subject.emtree	Liver cirrhosis
dc.subject.emtree	Liver transplantation
dc.subject.emtree	Male
dc.subject.emtree	Morbidity
dc.subject.emtree	Mortality
dc.subject.emtree	Portopulmonary hypertension
dc.subject.emtree	Risk assessment
dc.subject.emtree	Splenorenal shunt
dc.subject.emtree	Treatment contraindication
dc.subject.emtree	Treatment response
dc.subject.emtree	Complication
dc.subject.emtree	Drug combination
dc.subject.emtree	Hypertension, portal
dc.subject.emtree	Hypertension, pulmonary
dc.subject.emtree	Procedures
dc.subject.emtree	Bosentan
dc.subject.emtree	Furosemide
dc.subject.emtree	Insulin glargine
dc.subject.emtree	Lactulose
dc.subject.emtree	Pantoprazole
dc.subject.emtree	Propranolol
dc.subject.emtree	Sildenafil
dc.subject.emtree	Spironolactone
dc.subject.emtree	Ursodeoxycholic acid
dc.subject.emtree	Antihypertensive agent
dc.subject.emtree	Bosentan
dc.subject.emtree	Piperazine derivative
dc.subject.emtree	Purine derivative
dc.subject.emtree	Sildenafil
dc.subject.emtree	Sulfonamide
dc.subject.emtree	Vasodilator agent
dc.subject.mesh	Adult
dc.subject.mesh	Antihypertensive agents
dc.subject.mesh	Drug therapy, combination
dc.subject.mesh	Humans
dc.subject.mesh	Hypertension, portal
dc.subject.mesh	Hypertension, pulmonary
dc.subject.mesh	Liver transplantation
dc.subject.mesh	Male
dc.subject.mesh	Piperazines
dc.subject.mesh	Purines
dc.subject.mesh	Sulfonamides
dc.subject.mesh	Vasodilator agents
dc.subject.scopus	Hepatopulmonary Syndrome; Liver Transplantation; Portopulmonary Hypertension
dc.subject.wos	Gastroenterology & hepatology
dc.title	Treatment with a combination of bosentan and sildenafil allows for successful liver transplantation in a patient with portopulmonary hypertension
dc.type	Article
dc.wos.quartile	Q4 (Gastroenterology & hepatology)
dspace.entity.type	Publication
local.contributor.department	Tıp Fakültesi/Kardiyoloji Ana Bilim Dalı
local.indexed.at	WOS
local.indexed.at	Scopus
local.indexed.at	PubMed