Publication:
Morphometric investigation of neurons in the hippocampal CA1, CA3 areas and dentate gyrus in a rat model of sepsis

dc.contributor.buuauthorKafa, İlker Mustafa
dc.contributor.buuauthorArı, İlknur
dc.contributor.buuauthorKurt, Mustafa Ayberk
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentAnatomi Ana Bilim Dalı
dc.contributor.orcid0000-0003-3368-8123
dc.contributor.researcheridAAR-4341-2020
dc.contributor.researcheridAAG-7125-2021
dc.contributor.scopusid8450193200
dc.contributor.scopusid8450193100
dc.contributor.scopusid35603735000
dc.date.accessioned2022-03-15T08:40:07Z
dc.date.available2022-03-15T08:40:07Z
dc.date.issued2010-03
dc.description.abstractApproximately, half of the patients with progressive sepsis develop encephalopathy, but there is scarce knowledge onto question that how the sepsis associated encephalopathy contributes brain dysfunction. Hippocampus is one of the most vulnerable regions during experimental sepsis. In the present study, effects of sepsis on the neuronal density and morphology in CA1, CA3 and DG areas were investigated in a rat model of intraperitoneal sepsis. Twenty-four Wistar rats were divided into three different groups: faecal peritonitis group, sham-operated and un-operated control groups. Pyramidal neuron volume density was significantly higher in CA1 area of the faecal peritonitis group compared to both un-operated (p<0.05) and sham-operated (p<0.05) groups. Pyramidal neuron volume density was also significantly higher in CA3 area of the faecal peritonitis group compared to both un-operated (p<0.05) and sham-operated (p<0.05) groups. Mean nuclear diameter of pyramidal neurons in CA1 area of the faecal peritonitis group was significantly lower (p<0.05) compared to un-operated control group. Dark, shrunken neurons were frequently observed and neuroglial cells appeared to be prevalent in the faecal peritonitis group compared to control groups. These results collectively suggest that intraperitoneal sepsis does not initiate cell death in the early stages of sepsis, although morphological signs of neurodegeneration start to appear.
dc.identifier.citationKafa, İ. M. vd. (2010). "Morphometric investigation of neurons in the hippocampal CA1, CA3 areas and dentate gyrus in a rat model of sepsis". International Journal of Morphology, 28(1), 183-192.
dc.identifier.endpage192
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue1
dc.identifier.scopus2-s2.0-77954209352
dc.identifier.startpage183
dc.identifier.urihttps://doi.org/10.4067/S0717-95022010000100026
dc.identifier.urihttps://pdfs.semanticscholar.org/0dae/4a86a4ee740e259c5c4e07e1960bae9d6066.pdf
dc.identifier.urihttp://hdl.handle.net/11452/25035
dc.identifier.volume28
dc.identifier.wos000279003300026
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSOC Chilena Anatomia
dc.relation.journalInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSepsis
dc.subjectAnimal models of sepsis
dc.subjectFaecal peritonitis
dc.subjectHippocampus
dc.subjectSepsis associated encephalopathy
dc.subjectSeptic encephalopathy
dc.subjectCell-death
dc.subjectLaboratory models
dc.subjectBrain
dc.subjectPeritonitis
dc.subjectEdema
dc.subjectPathogenesis
dc.subjectMechanism
dc.subjectApoptosis
dc.subjectShock
dc.subjectAnatomy & morphology
dc.subject.scopusSepsis Associated Encephalopathy; Sepsis; Cognitive Dysfunction
dc.subject.wosAnatomy & morphology
dc.titleMorphometric investigation of neurons in the hippocampal CA1, CA3 areas and dentate gyrus in a rat model of sepsis
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Anatomi Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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