Publication:
3,4-Diaminopyridine and choline increase in vivo acetylcholine release in rat striatum

dc.contributor.buuauthorBüyükuysal, R. Levent
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.buuauthorSami, Aydın
dc.contributor.buuauthorKiran, Burhan K.
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmakoloji Ana Bilim Dalı
dc.contributor.researcheridD-5340-2015
dc.contributor.researcheridAAH-1657-2021
dc.date.accessioned2021-07-05T11:07:54Z
dc.date.available2021-07-05T11:07:54Z
dc.date.issued1995-04-13
dc.description.abstractWe investigated the effects of choline, 3,4-diaminopyridine and their combination on acetylcholine release from the corpus striatum of freely moving rats which were treated or not with atropine. Intraperitoneal administration of choline or intrastriatal administration of 3,4-diaminopyridine increased acetylcholine levels in striatal dialysates in a dose-dependent manner. When 3,4-diaminopyridine treatment was combined with choline, the observed effect was considerably greater than the sum of the increases produced by choline or 3,4-diaminopyridine alone. Administration of atropine (1 mu M) in the dialysing medium was also found to be effective to stimulate striatal acetylcholine levels. 3,4-Diaminopyridine did not affect acetylcholine levels under these conditions. Whereas the choline-induced increase in acetylcholine release was significantly potentiated by atropine, co-administration of 3,4-diaminopyridine with choline failed to produce a further significant increase in the presence of atropine. These results suggest that a highly effective means for increasing acetylcholine release involves two concurrent treatments that increase neuronal choline levels and inhibition of the negative feedback modulation of acetylcholine release.
dc.identifier.citationBüyükuysal, R. L. vd. (1995). ''3,4-Diaminopyridine and choline increase in vivo acetylcholine release in rat striatum''. European Journal of Pharmacology, 281(2), 179-185.
dc.identifier.endpage185
dc.identifier.issn0014-2999
dc.identifier.issue2
dc.identifier.pubmed7589205
dc.identifier.scopus2-s2.0-0028893043
dc.identifier.startpage179
dc.identifier.urihttps://doi.org/10.1016/0014-2999(95)00241-C
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/001429999500241C
dc.identifier.urihttp://hdl.handle.net/11452/21061
dc.identifier.volume281
dc.identifier.wosA1995RN82700008
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier Science BV
dc.relation.journalEuropean Journal of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcetylcholine
dc.subjectCholine
dc.subject3,4-Diaminopyridine
dc.subjectMicrodialysis
dc.subject4-Aminopyridine
dc.subjectSlices
dc.subjectStimulation
dc.subjectHippocampus
dc.subjectMembrane
dc.subjectMicrodialysis
dc.subjectTransmitter release
dc.subjectPotassium channels
dc.subjectCorpus striatum
dc.subjectInvivo release
dc.subjectPharmacology & pharmacy
dc.subject.wosPharmacology & pharmacy
dc.title3,4-Diaminopyridine and choline increase in vivo acetylcholine release in rat striatum
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Farmakoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atScopus

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