Publication:
Topical bupivacaine compared to lidocaine with epinephrine for post-tonsillectomy pain relief in children: A randomized controlled study

dc.contributor.authorÖzmen, Süay
dc.contributor.buuauthorÖzmen, Ömer Afşin
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentKulak Burun Boğaz Ana Bilim Dalı
dc.contributor.orcid0000-0002-9698-0546
dc.contributor.researcheridA-1452-2019
dc.contributor.scopusid55407733900
dc.date.accessioned2021-12-24T10:24:29Z
dc.date.available2021-12-24T10:24:29Z
dc.date.issued2011-06
dc.description.abstractObjective: To compare the topical administration of bupivacaine hydrochloride, lidocaine hydrochloride with epinephrine and saline in alleviating post tonsillectomy pain. Study design: A double-blind prospective randomized controlled clinical study. Methods: Between November 2008 and March 2009, 60 patients (32 males and 28 females) between ages of 1.5 and 15 years were recruited into the study. After informed consent was obtained from the parents, patients, admitted for tonsillectomy, were randomized into three groups using sealed envelops. Group 1 (20 patients, mean age 5.2 +/- 1.7) received topical lidocaine hydrochloride (20 mg/ml) with 0.00125% epinephrine. Group 2 (20 patients, mean age 6 +/- 3.7) received topical 0.5% bupivacaine hydrochloride and group 3 (20 patients, mean age 6.7 +/- 3.6) received topical saline. Results: The post-operative pain scores at 1 h were similar among the groups (p = 0.29). Pain scores in bupivacaine hydrochloride group were significantly lesser than the saline group at 5th, 13th, 17th and 21st hours, until the sixth day (p < 0.017). Moreover, pain scores of bupivacaine hydrochloride group were superior to lidocaine hydrochloride group starting at 17 h, until fourth day (p < 0.017). Pain scores of lidocaine hydrochloride group were lesser than saline group in the first and fifth days (p < 0.017), whereas, there was no significant difference at other times. Conclusion: Topical administration of bupivacaine hydrochloride proved to provide more efficient pain control than both saline and lidocaine without any drug related complication.
dc.identifier.citationÖzmen, Ö. A. ve Özmen, S. (2011). "Topical bupivacaine compared to lidocaine with epinephrine for post-tonsillectomy pain relief in children: A randomized controlled study". International Journal of Pediatric Otorhinolaryngology, 75(1), 77-80.
dc.identifier.endpage80
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.issue1
dc.identifier.pubmed21067823
dc.identifier.scopus2-s2.0-78650996409
dc.identifier.startpage77
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2010.10.013
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0165587610004805
dc.identifier.urihttp://hdl.handle.net/11452/23574
dc.identifier.volume75
dc.identifier.wos000287065800016
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier Ireland
dc.relation.collaborationSanayi
dc.relation.journalInternational Journal of Pediatric Otorhinolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOtorhinolaryngology
dc.subjectPediatrics
dc.subjectTonsillectomy
dc.subjectPain
dc.subjectBupivacaine
dc.subjectLidocaine
dc.subjectPostoperative tonsillar infiltration
dc.subjectPeritonsillar infiltration
dc.subjectPediatric tonsillectomy
dc.subjectDouble-blind
dc.subjectControlled trial
dc.subjectRopivacaine
dc.subjectAdenotonsillectomy
dc.subjectAnesthesia
dc.subjectReduction
dc.subjectMorbidity
dc.subject.emtreeAdrenalin
dc.subject.emtreeBupivacaine
dc.subject.emtreeLidocaine
dc.subject.emtreeAdolescent
dc.subject.emtreeAirway obstruction
dc.subject.emtreeArticle
dc.subject.emtreeBleeding
dc.subject.emtreeChild
dc.subject.emtreeDehydration
dc.subject.emtreeDouble blind procedure
dc.subject.emtreeDrug efficacy
dc.subject.emtreeFemale
dc.subject.emtreeFever
dc.subject.emtreeHalitosis
dc.subject.emtreeHuman
dc.subject.emtreeMajor clinical study
dc.subject.emtreeMale
dc.subject.emtreeOtalgia
dc.subject.emtreePain assessment
dc.subject.emtreePostoperative nausea
dc.subject.emtreePostoperative pain
dc.subject.emtreePostoperative vomiting
dc.subject.emtreePriority journal
dc.subject.emtreeProspective study
dc.subject.emtreeRandomized controlled trial
dc.subject.emtreeTonsillectomy
dc.subject.emtreeTrismus
dc.subject.meshAdministration, topical
dc.subject.meshAdolescent
dc.subject.meshAnesthetics, local
dc.subject.meshBupivacaine
dc.subject.meshChild
dc.subject.meshChild, preschool
dc.subject.meshDouble-blind method
dc.subject.meshDrug therapy, combination
dc.subject.meshEpinephrine
dc.subject.meshFemale
dc.subject.meshFollow-up studies
dc.subject.meshHumans
dc.subject.meshLidocaine
dc.subject.meshMale
dc.subject.meshPain measurement
dc.subject.meshPain, postoperative
dc.subject.meshPatient satisfaction
dc.subject.meshProspective studies
dc.subject.meshRisk assessment
dc.subject.meshTonsillectomy
dc.subject.scopusTonsillectomy; Palatine Tonsil; Postoperative Hemorrhage
dc.subject.wosOtorhinolaryngology
dc.subject.wosPediatrics
dc.titleTopical bupivacaine compared to lidocaine with epinephrine for post-tonsillectomy pain relief in children: A randomized controlled study
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Kulak Burun Boğaz Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

Files

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: