Publication:
Toward a biochemical diagnosis of nash: Insights from pathophysiology for distinguishing simple steatosis from steatohepatitis

dc.contributor.authorYılmaz, Yusuf
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.researcheridK-5792-2018
dc.contributor.scopusid6602927353
dc.date.accessioned2021-12-23T06:19:45Z
dc.date.available2021-12-23T06:19:45Z
dc.date.issued2011-02
dc.description.abstractWith the continuing epidemics of obesity and diabetes, nonalcoholic fatty liver disease (NAFLD) has received increased attention. Great efforts are being undertaken to improve the noninvasive diagnosis of NAFLD, with the ultimate goal of optimizing treatment options and clinical outcomes. Research suggests that blood-borne biochemical markers can be used to distinguish simple steatosis from nonalcoholic steatohepatitis (NASH), thus reducing the need of liver biopsy. Future developments in the field of diagnostic biochemistry within the spectrum of NAFLD can make this approach ideal for screening and monitoring purposes. In this review, we provide an overview of the different blood-borne markers which have been recently proposed for differentiating simple steatosis from NASH. We will also consider the practical and statistical issues that seem to be limiting the effective integration of biomarkers into clinical development.
dc.identifier.citationYilmaz, Y. ve Ulukaya, E. (2011). "Toward a biochemical diagnosis of nash: Insights from pathophysiology for distinguishing simple steatosis from steatohepatitis". Current Medicinal Chemistry, 18(5), 725-732.
dc.identifier.endpage732
dc.identifier.issn0929-8673
dc.identifier.issn1875-533X
dc.identifier.issue5
dc.identifier.pubmed21182485
dc.identifier.scopus2-s2.0-79951521515
dc.identifier.startpage725
dc.identifier.urihttps://doi.org/10.2174/092986711794480122
dc.identifier.urihttps://www.eurekaselect.com/73241/article
dc.identifier.urihttp://hdl.handle.net/11452/23474
dc.identifier.volume18
dc.identifier.wos000287301600004
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherBetham Science
dc.relation.collaborationYurt içi
dc.relation.journalCurrent Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiochemistry & molecular biology
dc.subjectPharmacology & pharmacy
dc.subjectNonalcoholic fatty liver disease
dc.subjectSteatosis
dc.subjectSteatohepatitis
dc.subjectBiomarkers
dc.subjectFatty liver-disease
dc.subjectDifferentiate simple steatosis
dc.subjectPolypeptide specific antigen
dc.subjectNonalcoholic steatohepatitis
dc.subjectInsulin-resistance
dc.subjectCardiovascular-disease
dc.subjectTherapeutic target
dc.subjectMetabolic syndrome
dc.subjectSoluble receptor
dc.subjectNatural-history
dc.subject.emtreeAdipocytokine
dc.subject.emtreeAdvanced glycation end product receptor
dc.subject.emtreeAngiopoietin like protein 3
dc.subject.emtreeBiochemical marker
dc.subject.emtreeChimerin
dc.subject.emtreeEndothelin 1
dc.subject.emtreeFerritin
dc.subject.emtreePrasterone
dc.subject.emtreeRetinol binding protein 4
dc.subject.emtreeUnclassified drug
dc.subject.emtreeAdipose tissue
dc.subject.emtreeApoptosis
dc.subject.emtreeArticle
dc.subject.emtreeBlood analysis
dc.subject.emtreeClinical assessment
dc.subject.emtreeDiagnostic accuracy
dc.subject.emtreeDifferential diagnosis
dc.subject.emtreeHuman
dc.subject.emtreeLiver biopsy
dc.subject.emtreeNon invasive procedure
dc.subject.emtreeNonalcoholic fatty liver
dc.subject.emtreePathophysiology
dc.subject.emtreeSteatosis
dc.subject.meshAdipose tissue
dc.subject.meshApoptosis
dc.subject.meshBiological markers
dc.subject.meshFatty liver
dc.subject.meshHumans
dc.subject.meshLiver
dc.subject.scopusFatty Liver; Proton Density (Concentration); Keratin-18
dc.subject.wosBiochemistry & molecular biology
dc.subject.wosChemistry, medicinal
dc.subject.wosPharmacology & pharmacy
dc.titleToward a biochemical diagnosis of nash: Insights from pathophysiology for distinguishing simple steatosis from steatohepatitis
dc.typeReview
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Biyokimya Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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