Publication: Toward a biochemical diagnosis of nash: Insights from pathophysiology for distinguishing simple steatosis from steatohepatitis
dc.contributor.author | Yılmaz, Yusuf | |
dc.contributor.buuauthor | Ulukaya, Engin | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Biyokimya Ana Bilim Dalı | |
dc.contributor.researcherid | K-5792-2018 | |
dc.contributor.scopusid | 6602927353 | |
dc.date.accessioned | 2021-12-23T06:19:45Z | |
dc.date.available | 2021-12-23T06:19:45Z | |
dc.date.issued | 2011-02 | |
dc.description.abstract | With the continuing epidemics of obesity and diabetes, nonalcoholic fatty liver disease (NAFLD) has received increased attention. Great efforts are being undertaken to improve the noninvasive diagnosis of NAFLD, with the ultimate goal of optimizing treatment options and clinical outcomes. Research suggests that blood-borne biochemical markers can be used to distinguish simple steatosis from nonalcoholic steatohepatitis (NASH), thus reducing the need of liver biopsy. Future developments in the field of diagnostic biochemistry within the spectrum of NAFLD can make this approach ideal for screening and monitoring purposes. In this review, we provide an overview of the different blood-borne markers which have been recently proposed for differentiating simple steatosis from NASH. We will also consider the practical and statistical issues that seem to be limiting the effective integration of biomarkers into clinical development. | |
dc.identifier.citation | Yilmaz, Y. ve Ulukaya, E. (2011). "Toward a biochemical diagnosis of nash: Insights from pathophysiology for distinguishing simple steatosis from steatohepatitis". Current Medicinal Chemistry, 18(5), 725-732. | |
dc.identifier.endpage | 732 | |
dc.identifier.issn | 0929-8673 | |
dc.identifier.issn | 1875-533X | |
dc.identifier.issue | 5 | |
dc.identifier.pubmed | 21182485 | |
dc.identifier.scopus | 2-s2.0-79951521515 | |
dc.identifier.startpage | 725 | |
dc.identifier.uri | https://doi.org/10.2174/092986711794480122 | |
dc.identifier.uri | https://www.eurekaselect.com/73241/article | |
dc.identifier.uri | http://hdl.handle.net/11452/23474 | |
dc.identifier.volume | 18 | |
dc.identifier.wos | 000287301600004 | |
dc.indexed.wos | SCIE | |
dc.language.iso | en | |
dc.publisher | Betham Science | |
dc.relation.collaboration | Yurt içi | |
dc.relation.journal | Current Medicinal Chemistry | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Biochemistry & molecular biology | |
dc.subject | Pharmacology & pharmacy | |
dc.subject | Nonalcoholic fatty liver disease | |
dc.subject | Steatosis | |
dc.subject | Steatohepatitis | |
dc.subject | Biomarkers | |
dc.subject | Fatty liver-disease | |
dc.subject | Differentiate simple steatosis | |
dc.subject | Polypeptide specific antigen | |
dc.subject | Nonalcoholic steatohepatitis | |
dc.subject | Insulin-resistance | |
dc.subject | Cardiovascular-disease | |
dc.subject | Therapeutic target | |
dc.subject | Metabolic syndrome | |
dc.subject | Soluble receptor | |
dc.subject | Natural-history | |
dc.subject.emtree | Adipocytokine | |
dc.subject.emtree | Advanced glycation end product receptor | |
dc.subject.emtree | Angiopoietin like protein 3 | |
dc.subject.emtree | Biochemical marker | |
dc.subject.emtree | Chimerin | |
dc.subject.emtree | Endothelin 1 | |
dc.subject.emtree | Ferritin | |
dc.subject.emtree | Prasterone | |
dc.subject.emtree | Retinol binding protein 4 | |
dc.subject.emtree | Unclassified drug | |
dc.subject.emtree | Adipose tissue | |
dc.subject.emtree | Apoptosis | |
dc.subject.emtree | Article | |
dc.subject.emtree | Blood analysis | |
dc.subject.emtree | Clinical assessment | |
dc.subject.emtree | Diagnostic accuracy | |
dc.subject.emtree | Differential diagnosis | |
dc.subject.emtree | Human | |
dc.subject.emtree | Liver biopsy | |
dc.subject.emtree | Non invasive procedure | |
dc.subject.emtree | Nonalcoholic fatty liver | |
dc.subject.emtree | Pathophysiology | |
dc.subject.emtree | Steatosis | |
dc.subject.mesh | Adipose tissue | |
dc.subject.mesh | Apoptosis | |
dc.subject.mesh | Biological markers | |
dc.subject.mesh | Fatty liver | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Liver | |
dc.subject.scopus | Fatty Liver; Proton Density (Concentration); Keratin-18 | |
dc.subject.wos | Biochemistry & molecular biology | |
dc.subject.wos | Chemistry, medicinal | |
dc.subject.wos | Pharmacology & pharmacy | |
dc.title | Toward a biochemical diagnosis of nash: Insights from pathophysiology for distinguishing simple steatosis from steatohepatitis | |
dc.type | Review | |
dc.wos.quartile | Q1 | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Biyokimya Ana Bilim Dalı | |
local.indexed.at | Scopus | |
local.indexed.at | WOS |
Files
License bundle
1 - 1 of 1
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: