Publication:
Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness

dc.contributor.buuauthorSağ, Saim
dc.contributor.buuauthorYıldız, Abdülmecit
dc.contributor.buuauthorGüllülü, Sümeyye
dc.contributor.buuauthorGüngören, Fatih
dc.contributor.buuauthorÖzdemir, Bülent
dc.contributor.buuauthorÇeğilli, Ercan
dc.contributor.buuauthorOruç, Ayşegül
dc.contributor.buuauthorErsoy, Alparslan
dc.contributor.buuauthorGüllülü, Mustafa
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentNefroloji Ana Bilim Dalı
dc.contributor.departmentKardiyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-0710-0923
dc.contributor.orcid0000-0001-8404-8252
dc.contributor.researcheridAAH-5054-2021
dc.contributor.researcheridAAH-4002-2021
dc.contributor.researcheridAAA-3163-2021
dc.contributor.researcheridAAW-9185-2020
dc.contributor.scopusid12140008100
dc.contributor.scopusid56256977500
dc.contributor.scopusid57204660708
dc.contributor.scopusid55747051400
dc.contributor.scopusid7004168959
dc.contributor.scopusid57144621700
dc.contributor.scopusid55133912100
dc.contributor.scopusid35612977100
dc.contributor.scopusid6602684544
dc.date.accessioned2022-11-18T12:16:37Z
dc.date.available2022-11-18T12:16:37Z
dc.date.issued2016-02-16
dc.description.abstractEpicardial adipose tissue thickness (EATT) is suggested as a novel marker of subclinical atherosclerosis. Despite increased carotid intima-media thickness (CIMT) in autosomal dominant polycystic kidney disease (ADPKD) patients, the extent of the relationship between CIMT and EATT is unknown. The main purpose of our study was to evaluate the relation between EATT and CIMT in normotensive ADPKD patients with well-preserved renal function. Fifty-five normotensive ADPKD patients with normal renal function and 50 healthy control subjects were included in the study. EATT and CIMT were measured by echocardiography in all subjects. Correlation between EATT and CIMT was evaluated in ADPKD patients, while multivariate linear regression analysis was performed to determine factors predicting EATT and CIMT. ADPKD patients had significantly higher levels CIMT [0.7 (0.4-1.2) vs. 0.5 (0.4-0.8) mm, p < 0.001] and EATT (6.8 +/- 2.7 vs. 4.8 +/- 1.2 mm, p < 0.001) as compared with control subjects. Significant positive correlation was found between EATT and CIMT (r = 0.58, p < 0.001). Higher CRP levels (OR 54.7, 95 % CI 37.44-72.01, p < 0.001) and having ADPKD (OR 10.2, 95 % CI 2.53-17.86, p = 0.01) were the only independent factors associated with a higher EATT. A higher age (OR 0.35, 95 % CI -0.02 to 0.71, p = 0.06) tended to be independently associated with a higher EATT. In conclusion, our findings suggest that EATT, being simply measured by echocardiography and correlated with CIMT, can be used to detect subclinical atherosclerosis in normotensive ADPKD patients.
dc.identifier.citationSağ, S. vd. (2016). "Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness". SpringerPlus, 5, 1-7.
dc.identifier.endpage7
dc.identifier.issn2193-1801
dc.identifier.pubmed27026905
dc.identifier.scopus2-s2.0-84959306803
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1186/s40064-016-1871-8
dc.identifier.urihttps://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4771685&blobtype=pdf
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771685/
dc.identifier.urihttp://hdl.handle.net/11452/29490
dc.identifier.volume5
dc.identifier.wos000371417200005
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSpringer
dc.relation.journalSpringerPlus
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectScience & technology - other topics
dc.subjectAutosomal dominant polycystic kidney disease
dc.subjectPreserved renal function
dc.subjectEarly atherosclerosis
dc.subjectEpicardial adipose tissue thickness
dc.subjectCarotid intima-media thickness
dc.subjectLeft-ventricular hypertrophy
dc.subjectFat thickness
dc.subjectEndothelial dysfunction
dc.subjectVisceral adiposity
dc.subjectEchocardiography
dc.subjectHemodialysis
dc.subjectAssociation
dc.subjectPentraxin-3
dc.subjectMass
dc.subject.scopusFat Thickness; Adipose Tissues; Coronary Artery Disease
dc.subject.wosMultidisciplinary sciences
dc.titleEarly atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Kardiyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Nefroloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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