Publication:
Long noncoding RNA MALAT1 may be a prognostic biomarker in IDH1/2 wild-type primary glioblastomas

dc.contributor.authorTezcan, Gülçin
dc.contributor.buuauthorArgadal, Ömer Gökay
dc.contributor.buuauthorMutlu, Melis
dc.contributor.buuauthorAksoy, Seçil
dc.contributor.buuauthorKocaeli, Hasan
dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorCivan, Muhammet Nafi
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorCecener, Gülşah
dc.contributor.buuauthorBekar, Ahmet
dc.contributor.buuauthorTaşkapılıoğlu, M. Özgür
dc.contributor.buuauthorTekin, Çağla
dc.contributor.buuauthorTezcan, Gülçin
dc.contributor.buuauthorTolunay, Şahine
dc.contributor.departmentBursaUludağ Üniversitesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentNöroşirürji Ana Bilim Dalı
dc.contributor.orcid0000-0002-3760-9755
dc.contributor.orcid0000-0002-1619-6680
dc.contributor.orcid0000-0001-7904-883X
dc.contributor.orcid0000-0002-3820-424X
dc.contributor.orcid0000-0001-5472-9065
dc.contributor.researcheridFPB-0403-2022
dc.contributor.researcheridCCA-2925-2022
dc.contributor.researcheridFDK-3229-2022
dc.contributor.researcheridCMP-5265-2022
dc.contributor.researcheridCGB-7869-2022
dc.contributor.researcheridGDC-6329-2022
dc.contributor.researcheridAAH-3843-2020
dc.contributor.researcheridAAI-1612-2021
dc.contributor.scopusid57214765002
dc.contributor.scopusid57212065763
dc.contributor.scopusid57193933334
dc.contributor.scopusid6603500567
dc.contributor.scopusid6602965754
dc.contributor.scopusid57214763395
dc.contributor.scopusid55665145000
dc.contributor.scopusid6508156530
dc.contributor.scopusid6603677218
dc.contributor.scopusid25936798300
dc.contributor.scopusid57214764024
dc.contributor.scopusid25650627600
dc.date.accessioned2024-02-16T12:25:04Z
dc.date.available2024-02-16T12:25:04Z
dc.date.issued2020
dc.description.abstractPrimary glioblastoma (GB) is the most aggressive type of brain tumors. While mutations in isocitrate dehydrogenase (IDH) genes are frequent in secondary GBs and correlate with a better prognosis, most primary GBs are IDH wild-type. Recent studies have shown that the long noncoding RNA metastasis associated lung adenocarcinoma transcript-1 (MALAT1) is associated with aggressive tumor phenotypes in different cancers. Our aim was to clarify the prognostic significance of MALAT1 in IDH1/2 wild-type primary GB tumors. We analyzed IDH1/2 mutation status in 75 patients with primary GB by DNA sequencing. The expression of MALAT1 was detected in the 75 primary GB tissues and 5 normal brain tissues using reverse transcription quantitative PCR (RT-qPCR). The associations between MALAT1 expression, IDH1/2 mutation status, and clinicopathological variables of patients were determined. IDH1 (R132H) mutation was observed in 5/75 primary GBs. IDH2 (R172H) mutation was not detected in any of our cases. MALAT1 expression was significantly upregulated in primary GB vs. normal brain tissues (p = 0.025). Increased MALAT1 expression in IDH1/2 wild-type primary GBs correlated with patient age and tumor localization (p = 0.032 and p = 0.025, respectively). A multivariate analysis showed that high MALAT1 expression was an unfavorable prognostic factor for overall survival (p = 0.034) in IDH1/2 wild-type primary GBs. High MALAT1 expression may have a prognostic role in primary GBs independent of IDH mutations.
dc.identifier.citationArgadal, Ö. G. vd. (2020). "Long noncoding RNA MALAT1 may be a prognostic biomarker in IDH1/2 wild-type primary glioblastomas". Bosnian Journal of Basic Medical Sciences, 20(1), 63-69.
dc.identifier.endpage69
dc.identifier.issn1512-8601
dc.identifier.issn1840-4812
dc.identifier.issue1
dc.identifier.pubmed31479414
dc.identifier.scopus2-s2.0-85079075818
dc.identifier.startpage63
dc.identifier.urihttps://doi.org/10.17305/bjbms.2019.4297
dc.identifier.urihttps://www.bjbms.org/ojs/index.php/bjbms/article/view/4297
dc.identifier.urihttps://hdl.handle.net/11452/39821
dc.identifier.volume20
dc.identifier.wos000512952000008
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherAssoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo
dc.relation.bapOUAP(T)-2015/3
dc.relation.collaborationYurt dışı
dc.relation.journalBosnian Journal of Basic Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLong noncoding RNA
dc.subjectMALAT1
dc.subjectBiomarker
dc.subjectPrognosis
dc.subjectIDH1/2
dc.subjectPrimary glioblastoma
dc.subjectIsocitrate dehydrogenase
dc.subjectHypermethylation
dc.subjectResearch & experimental medicine
dc.subject.emtreeIDH1 protein, human
dc.subject.emtreeIsocitrate dehydrogenase
dc.subject.emtreeIsocitrate dehydrogenase 2
dc.subject.emtreeHuman
dc.subject.emtreeLong untranslated RNA
dc.subject.emtreeMALAT1 long non-coding RNA, human
dc.subject.emtreeMessenger RNA
dc.subject.emtreeTumor marker
dc.subject.emtreeAdult
dc.subject.emtreeAged
dc.subject.emtreeBrain tumor
dc.subject.emtreeFemale
dc.subject.emtreeGenetics
dc.subject.emtreeGlioblastoma
dc.subject.emtreeHuman
dc.subject.emtreeMale
dc.subject.emtreeMetabolism
dc.subject.emtreeMiddle aged
dc.subject.emtreeMutation
dc.subject.emtreeRetrospective study
dc.subject.emtreeReverse transcription polymerase chain reaction
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBiomarkers, tumor
dc.subject.meshBrain neoplasms
dc.subject.meshFemale
dc.subject.meshGlioblastoma
dc.subject.meshHumans
dc.subject.meshIsocitrate dehydrogenase
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshMutation
dc.subject.meshRetrospective studies
dc.subject.meshReverse transcriptase polymerase chain reaction
dc.subject.meshRNA
dc.subject.meshLong noncoding
dc.subject.meshRNA, messenger
dc.subject.scopusIsocitrate Dehydrogenase; Mutation; Epidermal Growth Factor Receptor VIII
dc.subject.wosMedicine, research & experimental
dc.titleLong noncoding RNA MALAT1 may be a prognostic biomarker in IDH1/2 wild-type primary glioblastomas
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentBursaUludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

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