Publication:
Susceptibility of red blood cell lipids to in vitro oxidation and antioxidant status in preeclampsia

dc.contributor.buuauthorDirican, Melahat
dc.contributor.buuauthorŞafak, Özlem
dc.contributor.buuauthorUncu, Gürkan
dc.contributor.buuauthorSarandöl, Emre
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentkadın Hastalıkları Ana Bilim Dalı
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.orcid0000-0002-2593-7196
dc.contributor.researcheridABE-1716-2020
dc.contributor.researcheridAAG-6985-2021
dc.contributor.scopusid6601919847
dc.contributor.scopusid6508363078
dc.contributor.scopusid6603716169
dc.contributor.scopusid55943324800
dc.date.accessioned2024-03-29T11:20:02Z
dc.date.available2024-03-29T11:20:02Z
dc.date.issued2008-10
dc.description.abstractObjective: To investigate susceptibility of red blood cell (RBC) lipids to oxidation and antioxidant status in preeclampsia. Study design: Twenty-one women with mild preeclampsia, 21 women with severe preeclampsia, and 20 healthy pregnant women were included in this cross-sectional study. Susceptibility of RBC to oxidative stress was determined by measuring RBC-malondialdehyde levels after incubation with hydrogen peroxide. Vitamins E and C, total carotenoids and erythrocyte superoxide dismutase and glutathione peroxidase (GPx) activities and serum total antioxidant capacity (TAC) were determined spectrophotometrically. One-way analysis of variance and correlation analysis were used for statistical analyses. Results: Compared with the normal pregnant women, susceptibility of RBC to oxidation was enhanced in the mild (p < 0.05) and severe (p < 0.01) preeclampsia groups, TAC was lower in the mild (p < 0.01) and severe (p < 0.001) preeclampsia groups. Vitamin C level was decreased in severe preeclampsia and total carotene level was decreased in mild and severe preeclampsia groups (p < 0.05). GPx activity was also decreased in the mild (p < 0.01) and severe (p < 0.05) preeclampsia groups. Conclusion: The results of the present study supported tire oxidative stress hypothesis of preeclampsia and it is possible that RBC play a role in the pathophysiology of the disease.
dc.identifier.citationDirican, M. vd. (2008). "Susceptibility of red blood cell lipids to in vitro oxidation and antioxidant status in preeclampsia". European Journal of Obstetrics and Gynecology and Reproductive Biology, 140 (2), 158-164.
dc.identifier.endpage164
dc.identifier.issn0301-2115
dc.identifier.issue2
dc.identifier.pubmed16914260
dc.identifier.scopus2-s2.0-52949142746
dc.identifier.startpage158
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2006.07.011
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0301211506003915
dc.identifier.urihttps://hdl.handle.net/11452/40680
dc.identifier.volume140
dc.identifier.wos000260660300002
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.bap2001/54
dc.relation.journalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOxidative stress
dc.subjectPreeclampsia
dc.subjectRed blood cell
dc.subjectTotal antioxidant capacity
dc.subjectObstetrics & gynecology
dc.subjectReproductive biology
dc.subjectGlutathione-peroxidase
dc.subjectAutomated-method
dc.subjectNormal-pregnancy
dc.subjectVitamin-e
dc.subjectEclampsia
dc.subjectStress
dc.subjectPlasma
dc.subjectAcid
dc.subjectSuperoxide
dc.subjectMembrane
dc.subject.emtreeAlpha tocopherol
dc.subject.emtreeAscorbic acid
dc.subject.emtreeCarotenoid
dc.subject.emtreeGlutathione peroxidase
dc.subject.emtreeHydrogen peroxide
dc.subject.emtreeMalonaldehyde
dc.subject.emtreeSuperoxide dismutase
dc.subject.emtreeAdult
dc.subject.emtreeAntioxidant activity
dc.subject.emtreeArticle
dc.subject.emtreeCell activity
dc.subject.emtreeCell function
dc.subject.emtreeClinical article
dc.subject.emtreeControlled study
dc.subject.emtreeEnzyme activity
dc.subject.emtreeErythrocyte
dc.subject.emtreeFemale
dc.subject.emtreeHuman
dc.subject.emtreeIn vitro study
dc.subject.emtreeoxidation
dc.subject.emtreeOxidative stress
dc.subject.emtreePreeclampsia
dc.subject.emtreePriority journal
dc.subject.scopusPlacenta Growth Factor; Pregnancy Toxemia; Biomarkers
dc.subject.wosObstetrics & gynecology
dc.subject.wosReproductive biology
dc.titleSusceptibility of red blood cell lipids to in vitro oxidation and antioxidant status in preeclampsia
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Biyokimya Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/kadın Hastalıkları Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atScopus

Files

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: