Publication: Susceptibility of red blood cell lipids to in vitro oxidation and antioxidant status in preeclampsia
dc.contributor.buuauthor | Dirican, Melahat | |
dc.contributor.buuauthor | Şafak, Özlem | |
dc.contributor.buuauthor | Uncu, Gürkan | |
dc.contributor.buuauthor | Sarandöl, Emre | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | kadın Hastalıkları Ana Bilim Dalı | |
dc.contributor.department | Biyokimya Ana Bilim Dalı | |
dc.contributor.orcid | 0000-0002-2593-7196 | |
dc.contributor.researcherid | ABE-1716-2020 | |
dc.contributor.researcherid | AAG-6985-2021 | |
dc.contributor.scopusid | 6601919847 | |
dc.contributor.scopusid | 6508363078 | |
dc.contributor.scopusid | 6603716169 | |
dc.contributor.scopusid | 55943324800 | |
dc.date.accessioned | 2024-03-29T11:20:02Z | |
dc.date.available | 2024-03-29T11:20:02Z | |
dc.date.issued | 2008-10 | |
dc.description.abstract | Objective: To investigate susceptibility of red blood cell (RBC) lipids to oxidation and antioxidant status in preeclampsia. Study design: Twenty-one women with mild preeclampsia, 21 women with severe preeclampsia, and 20 healthy pregnant women were included in this cross-sectional study. Susceptibility of RBC to oxidative stress was determined by measuring RBC-malondialdehyde levels after incubation with hydrogen peroxide. Vitamins E and C, total carotenoids and erythrocyte superoxide dismutase and glutathione peroxidase (GPx) activities and serum total antioxidant capacity (TAC) were determined spectrophotometrically. One-way analysis of variance and correlation analysis were used for statistical analyses. Results: Compared with the normal pregnant women, susceptibility of RBC to oxidation was enhanced in the mild (p < 0.05) and severe (p < 0.01) preeclampsia groups, TAC was lower in the mild (p < 0.01) and severe (p < 0.001) preeclampsia groups. Vitamin C level was decreased in severe preeclampsia and total carotene level was decreased in mild and severe preeclampsia groups (p < 0.05). GPx activity was also decreased in the mild (p < 0.01) and severe (p < 0.05) preeclampsia groups. Conclusion: The results of the present study supported tire oxidative stress hypothesis of preeclampsia and it is possible that RBC play a role in the pathophysiology of the disease. | |
dc.identifier.citation | Dirican, M. vd. (2008). "Susceptibility of red blood cell lipids to in vitro oxidation and antioxidant status in preeclampsia". European Journal of Obstetrics and Gynecology and Reproductive Biology, 140 (2), 158-164. | |
dc.identifier.endpage | 164 | |
dc.identifier.issn | 0301-2115 | |
dc.identifier.issue | 2 | |
dc.identifier.pubmed | 16914260 | |
dc.identifier.scopus | 2-s2.0-52949142746 | |
dc.identifier.startpage | 158 | |
dc.identifier.uri | https://doi.org/10.1016/j.ejogrb.2006.07.011 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0301211506003915 | |
dc.identifier.uri | https://hdl.handle.net/11452/40680 | |
dc.identifier.volume | 140 | |
dc.identifier.wos | 000260660300002 | |
dc.indexed.wos | SCIE | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.relation.bap | 2001/54 | |
dc.relation.journal | European Journal of Obstetrics and Gynecology and Reproductive Biology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Oxidative stress | |
dc.subject | Preeclampsia | |
dc.subject | Red blood cell | |
dc.subject | Total antioxidant capacity | |
dc.subject | Obstetrics & gynecology | |
dc.subject | Reproductive biology | |
dc.subject | Glutathione-peroxidase | |
dc.subject | Automated-method | |
dc.subject | Normal-pregnancy | |
dc.subject | Vitamin-e | |
dc.subject | Eclampsia | |
dc.subject | Stress | |
dc.subject | Plasma | |
dc.subject | Acid | |
dc.subject | Superoxide | |
dc.subject | Membrane | |
dc.subject.emtree | Alpha tocopherol | |
dc.subject.emtree | Ascorbic acid | |
dc.subject.emtree | Carotenoid | |
dc.subject.emtree | Glutathione peroxidase | |
dc.subject.emtree | Hydrogen peroxide | |
dc.subject.emtree | Malonaldehyde | |
dc.subject.emtree | Superoxide dismutase | |
dc.subject.emtree | Adult | |
dc.subject.emtree | Antioxidant activity | |
dc.subject.emtree | Article | |
dc.subject.emtree | Cell activity | |
dc.subject.emtree | Cell function | |
dc.subject.emtree | Clinical article | |
dc.subject.emtree | Controlled study | |
dc.subject.emtree | Enzyme activity | |
dc.subject.emtree | Erythrocyte | |
dc.subject.emtree | Female | |
dc.subject.emtree | Human | |
dc.subject.emtree | In vitro study | |
dc.subject.emtree | oxidation | |
dc.subject.emtree | Oxidative stress | |
dc.subject.emtree | Preeclampsia | |
dc.subject.emtree | Priority journal | |
dc.subject.scopus | Placenta Growth Factor; Pregnancy Toxemia; Biomarkers | |
dc.subject.wos | Obstetrics & gynecology | |
dc.subject.wos | Reproductive biology | |
dc.title | Susceptibility of red blood cell lipids to in vitro oxidation and antioxidant status in preeclampsia | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Biyokimya Ana Bilim Dalı | |
local.contributor.department | Tıp Fakültesi/kadın Hastalıkları Ana Bilim Dalı | |
local.indexed.at | PubMed | |
local.indexed.at | Scopus |
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