Publication:
Genotoxic effect of epirubicin in mouse bone marrow in vivo

dc.contributor.buuauthorŞen, Asuman Karakaş
dc.contributor.buuauthorKarakaş, Emin
dc.contributor.buuauthorBilaloğlu, Rahmi
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentYenişehir Meslek Yüksekokulu
dc.contributor.departmentBiyoloji Bölümü
dc.contributor.researcheridAAI-4483-2021
dc.contributor.scopusid6506180901
dc.contributor.scopusid12243636400
dc.contributor.scopusid6505804122
dc.date.accessioned2022-04-12T06:38:22Z
dc.date.available2022-04-12T06:38:22Z
dc.date.issued2010
dc.description.abstractThe genotoxic effect of epirubicin, a semisynthetic anthracycline antibiotic which has been used as an anticancer drug, was investigated in vivo on bone marrow cells of Swiss albino mice using the micronucleus test. To determine the incidence of micronuclei, mice were injected intraperitoneally with the drug at single doses of 4, 6, 8, and 10 mg/kg body weight. Then, bone marrow was sampled 18, 24, 36, and 48 h after the treatment. Polychromatic and normochromatic erythrocytes were examined for the presence of micronuclei. Epirubicin significantly increased the frequency of micronucleated polychromatic erythrocytes (MNPCEs) for all treatment periods compared with the negative control (P < 0.001). The frequency of MNPCEs increased with the dose, but at the highest dose used (which is considered to be quite toxic), the frequency of MNPCEs was rather lower. Epirubicin also decreased the ratio of polychromatic to normochromatic erythrocytes (PCE/NCE) for all sampling intervals, which is indicative of bone marrow cytotoxicity. It can be concluded from the present study that the anticancer drug epirubicin has genotoxic effects on mouse bone marrow cells.
dc.identifier.citationŞen, A. K. vd. (2010). "Genotoxic effect of epirubicin in mouse bone marrow in vivo". Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 65(3-4), 211-217.
dc.identifier.endpage217
dc.identifier.issn0939-5075
dc.identifier.issn1865-7125
dc.identifier.issue3-4
dc.identifier.pubmed20469640
dc.identifier.scopus2-s2.0-77953051183
dc.identifier.startpage211
dc.identifier.urihttps://doi.org/10.1515/znc-2010-3-408
dc.identifier.urihttps://www.degruyter.com/document/doi/10.1515/znc-2010-3-408/html
dc.identifier.urihttp://hdl.handle.net/11452/25721
dc.identifier.volume65
dc.identifier.wos000278441900008
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWalter de Gruyter
dc.relation.journalZeitschrift fur Naturforschung - Section C Journal of Biosciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpirubicin
dc.subjectMicronucleus
dc.subjectGenotoxicity
dc.subjectAcute promyelocytic leukemia
dc.subjectDNA topoisomerase-II
dc.subjectBreast-cancer
dc.subjectAnthracycline antibiotics
dc.subjectMicronucleus induction
dc.subjectDoxorubicin
dc.subjectCells
dc.subjectTherapy
dc.subjectPharmacology
dc.subjectDamage
dc.subjectBiochemistry & molecular biology
dc.subjectPharmacology & pharmacy
dc.subject.emtreeEpirubicin
dc.subject.emtreeAnimal
dc.subject.emtreeArticle
dc.subject.emtreeBone marrow cell
dc.subject.emtreeCytology
dc.subject.emtreeDNA damage
dc.subject.emtreeDrug effect
dc.subject.emtreeErythrocyte
dc.subject.emtreeErythrocyte disorder
dc.subject.emtreeFemale
dc.subject.emtreeLD 50
dc.subject.emtreeMale
dc.subject.emtreeMicronucleus test
dc.subject.emtreeMouse
dc.subject.emtreePathology
dc.subject.meshAnimals
dc.subject.meshBone marrow cells
dc.subject.meshDNA damage
dc.subject.meshEpirubicin
dc.subject.meshErythrocytes
dc.subject.meshErythrocytes, abnormal
dc.subject.meshFemale
dc.subject.meshLethal dose 50
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshMicronucleus Tests
dc.subject.scopusSabarubicin; Anthracyclines; Intraday
dc.subject.wosBiochemistry & molecular biology
dc.subject.wosPharmacology & pharmacy
dc.titleGenotoxic effect of epirubicin in mouse bone marrow in vivo
dc.typeArticle
dc.wos.quartileQ4
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Bölümü
local.contributor.departmentYenişehir Meslek Yüksekokulu
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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