Publication:
Saccharomyces cerevisiae Beta-Glucan induces Interferon-Gamma production in human T cells via IL-12

dc.contributor.authorBudak, Ferah
dc.contributor.authorGöral, Güher
dc.contributor.authorOral, Haluk Barbaros
dc.contributor.buuauthorBUDAK, FERAH
dc.contributor.buuauthorGöral, Güher
dc.contributor.buuauthorORAL, HALUK BARBAROS
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentMikrobiyoloji ve Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.contributor.departmentİmmünoloji Bilim Dalı
dc.contributor.orcid0000-0001-7625-9148
dc.contributor.orcid0000-0003-0463-6818
dc.contributor.researcheridF-4657-2014
dc.contributor.researcheridK-7285-2012
dc.contributor.researcheridIZP-9398-2023
dc.date.accessioned2024-10-15T12:45:26Z
dc.date.available2024-10-15T12:45:26Z
dc.date.issued2008-01-01
dc.description.abstractBeta (beta)-Glucans are biological response modifiers with potent effects on the immune system. They are glucose polymers present in the cell walls of plants, fungi, and bacteria, and are considered to be pathogen-associated molecular patterns (PAMPs). It has been reported that these polymers have a variety of effects on the immune system, including anti-tumor and anti-infective activities against fungal, bacterial, viral, and protozoal infections. In this study, we investigated the effects of Saccharomyces cerevisiae beta-glucan on IFN-gamma production capacity of T cells. After 6 days incubation of human peripheral blood mononuclear cells in the presence or absence beta-glucan, IFN-gamma production and secretion were determined by flow cytometry and ELISA, respectively. beta-glucan significantly upregulated IFN-gamma production. In contrast, neutralization of IL-12 activity by anti-IL-12 decreased IFN-gamma synthesis. These data suggest that beta-glucan may support anti-tumour and anti-infective immune responses by increasing IL-12-induced IFN-gamma production in T cells.
dc.identifier.endpage26
dc.identifier.issn1301-109X
dc.identifier.issue1
dc.identifier.startpage21
dc.identifier.urihttps://hdl.handle.net/11452/46468
dc.identifier.volume13
dc.identifier.wos000420067600005
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherGalenos Yayınevi
dc.relation.journalTurkish Journal of Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBeta-glucan
dc.subjectIfn-gamma
dc.subjectIl-12
dc.subjectT cells
dc.subjectImmunology
dc.titleSaccharomyces cerevisiae Beta-Glucan induces Interferon-Gamma production in human T cells via IL-12
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Ana Bilim Dalı/İmmünoloji Bilim Dalı
local.indexed.atWOS
relation.isAuthorOfPublication26fb3aa9-55a8-4fa3-8a4a-9c449958d4f5
relation.isAuthorOfPublicationbc853dab-a811-42b9-b03b-6d5fe067efe8
relation.isAuthorOfPublication.latestForDiscovery26fb3aa9-55a8-4fa3-8a4a-9c449958d4f5

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