Publication:
Parathyroid hormone-related protein promotes bone loss in T-cell leukemia as well as in solid tumors

dc.contributor.authorKohart, Nicole A.
dc.contributor.authorElshafae, Said M.
dc.contributor.authorDemirer, Aylin A.
dc.contributor.authorDirksen, Wessel P.
dc.contributor.authorBreitbach, Justin T.
dc.contributor.authorShu, Sherry T.
dc.contributor.authorXiang, Jingyu
dc.contributor.authorWeilbaecher, Katherine N.
dc.contributor.authorRosol, Thomas J.
dc.contributor.buuauthorALASONYALILAR DEMİRER, AYLİN
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.
dc.contributor.researcheridERL-7504-2022
dc.date.accessioned2024-07-02T06:59:21Z
dc.date.available2024-07-02T06:59:21Z
dc.date.issued2020-01-28
dc.description.abstractParathyroid hormone-related protein (PTHrP) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) are important factors that increase bone resorption and hypercalcemia in adult T-cell leukemia (ATL). We investigated the role of PTHrP and MIP-1 alpha in the development of local osteolytic lesions in T-cell leukemia through overexpression in Jurkat T-cells. Injections of Jurkat-PTHrP and Jurkat-MIP-1 alpha into the tibia and the left ventricle of NSG mice were performed to evaluate tumor growth and metastasis in vivo. Jurkat-pcDNA tibial neoplasms grew at a significantly greater rate and total tibial tumor burden was significantly greater than Jurkat-PTHrP neoplasms. Despite the lower tibial tumor burden, Jurkat-PTHrP bone neoplasms had significantly greater osteolysis than Jurkat-pcDNA and Jurkat-MIP-1 alpha neoplasms. Jurkat-PTHrP and Jurkat-pcDNA cells preferentially metastasized to bone following intracardiac injection, though the overall metastatic burden was lower in Jurkat-PTHrP mice. These findings demonstrate that PTHrP induced pathologic osteolysis in T-cell leukemia but did not increase the incidence of skeletal metastasis.
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Cancer Institute (NCI) - P01 CA100730 - P30 CA016058
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA - T32 OD010429
dc.identifier.doi10.1080/10428194.2019.1672055
dc.identifier.endpage419
dc.identifier.issn1042-8194
dc.identifier.issue2
dc.identifier.startpage409
dc.identifier.urihttps://doi.org/10.1080/10428194.2019.1672055
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/10428194.2019.1672055
dc.identifier.urihttps://hdl.handle.net/11452/42695
dc.identifier.volume61
dc.identifier.wos000509037800021
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.journalLeukemia & Lymphoma
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMacrophage-inflammatory protein-1-alpha
dc.subjectSerum-levels
dc.subjectMouse model
dc.subjectHypercalcemia
dc.subjectExpression
dc.subjectPthrp
dc.subjectMetastases
dc.subjectHtlv-1
dc.subjectLeukemia/lymphoma
dc.subjectLocalization
dc.subjectCell lines and animal models
dc.subjectT-cell leukemia
dc.subjectPthrp
dc.subjectMip-1 alpha
dc.subjectMetastasis
dc.subjectBone resorption
dc.subjectOncology
dc.subjectHematology
dc.titleParathyroid hormone-related protein promotes bone loss in T-cell leukemia as well as in solid tumors
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication0181d6a3-f0f7-40e3-9dc8-9dc86a78ac8e
relation.isAuthorOfPublication.latestForDiscovery0181d6a3-f0f7-40e3-9dc8-9dc86a78ac8e

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