Publication: Parathyroid hormone-related protein promotes bone loss in T-cell leukemia as well as in solid tumors
dc.contributor.author | Kohart, Nicole A. | |
dc.contributor.author | Elshafae, Said M. | |
dc.contributor.author | Demirer, Aylin A. | |
dc.contributor.author | Dirksen, Wessel P. | |
dc.contributor.author | Breitbach, Justin T. | |
dc.contributor.author | Shu, Sherry T. | |
dc.contributor.author | Xiang, Jingyu | |
dc.contributor.author | Weilbaecher, Katherine N. | |
dc.contributor.author | Rosol, Thomas J. | |
dc.contributor.buuauthor | ALASONYALILAR DEMİRER, AYLİN | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı. | |
dc.contributor.researcherid | ERL-7504-2022 | |
dc.date.accessioned | 2024-07-02T06:59:21Z | |
dc.date.available | 2024-07-02T06:59:21Z | |
dc.date.issued | 2020-01-28 | |
dc.description.abstract | Parathyroid hormone-related protein (PTHrP) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) are important factors that increase bone resorption and hypercalcemia in adult T-cell leukemia (ATL). We investigated the role of PTHrP and MIP-1 alpha in the development of local osteolytic lesions in T-cell leukemia through overexpression in Jurkat T-cells. Injections of Jurkat-PTHrP and Jurkat-MIP-1 alpha into the tibia and the left ventricle of NSG mice were performed to evaluate tumor growth and metastasis in vivo. Jurkat-pcDNA tibial neoplasms grew at a significantly greater rate and total tibial tumor burden was significantly greater than Jurkat-PTHrP neoplasms. Despite the lower tibial tumor burden, Jurkat-PTHrP bone neoplasms had significantly greater osteolysis than Jurkat-pcDNA and Jurkat-MIP-1 alpha neoplasms. Jurkat-PTHrP and Jurkat-pcDNA cells preferentially metastasized to bone following intracardiac injection, though the overall metastatic burden was lower in Jurkat-PTHrP mice. These findings demonstrate that PTHrP induced pathologic osteolysis in T-cell leukemia but did not increase the incidence of skeletal metastasis. | |
dc.description.sponsorship | United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Cancer Institute (NCI) - P01 CA100730 - P30 CA016058 | |
dc.description.sponsorship | United States Department of Health & Human Services National Institutes of Health (NIH) - USA - T32 OD010429 | |
dc.identifier.doi | 10.1080/10428194.2019.1672055 | |
dc.identifier.endpage | 419 | |
dc.identifier.issn | 1042-8194 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 409 | |
dc.identifier.uri | https://doi.org/10.1080/10428194.2019.1672055 | |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1672055 | |
dc.identifier.uri | https://hdl.handle.net/11452/42695 | |
dc.identifier.volume | 61 | |
dc.identifier.wos | 000509037800021 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Taylor & Francis | |
dc.relation.journal | Leukemia & Lymphoma | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Macrophage-inflammatory protein-1-alpha | |
dc.subject | Serum-levels | |
dc.subject | Mouse model | |
dc.subject | Hypercalcemia | |
dc.subject | Expression | |
dc.subject | Pthrp | |
dc.subject | Metastases | |
dc.subject | Htlv-1 | |
dc.subject | Leukemia/lymphoma | |
dc.subject | Localization | |
dc.subject | Cell lines and animal models | |
dc.subject | T-cell leukemia | |
dc.subject | Pthrp | |
dc.subject | Mip-1 alpha | |
dc.subject | Metastasis | |
dc.subject | Bone resorption | |
dc.subject | Oncology | |
dc.subject | Hematology | |
dc.title | Parathyroid hormone-related protein promotes bone loss in T-cell leukemia as well as in solid tumors | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 0181d6a3-f0f7-40e3-9dc8-9dc86a78ac8e | |
relation.isAuthorOfPublication.latestForDiscovery | 0181d6a3-f0f7-40e3-9dc8-9dc86a78ac8e |
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