Publication:
Smoking habits are an independent prognostic factor in patients with lung cancer

Placeholder

Organizational Units

Authors

Deligönül, Adem
Evrensel, Türkan

Authors

Avcı, Nilüfer
Hayar, Murat
Altmışdörtoğlu, Özgür
Ordu, Çetin

Advisor

Language

Publisher:

Wiley

Journal Title

Journal ISSN

Volume Title

Abstract

ObjectivesThe role of tobacco in the pathogenesis of lung cancer (LC) has been clearly established. Based on the epidemiological evidence that smoking may influence LC progression, we investigated the idea that smoking behavior could be associated with overall survival (OS) in this group of patients. MethodsA total of 351 patients with LC (311 men and 40 women) were reviewed. Smoking status was assessed as tobacco users or non-users. To calculate pack-years of smoking, the average of number of cigarettes smoked per day was divided by 20 to give packs per day, and then multiplied by the total number of years of smoking. OS was the main outcome measure. ResultsThe mean follow-up was 3.31.2 years. Kaplan-Meier plots of OS by use of tobacco revealed significant differences by smoking status (log-rank=5.44, P<0.01), indicating a reduced survival rate in tobacco users. The effect on OS of the amount of cigarette smoking was also evident when we subdivided the former and current smokers into7 (mean value) pack-years and >7 pack-years groups (log-rank=4.27, P<0.05). After adjusting for all potential confounders, tobacco smoking retained its independent prognostic significance for OS (hazard ratio=1.53, 95% confidence interval=1.19-2.17, P=0.02). ConclusionsOur data indicate that cigarette smoking is significantly associated with a poor prognosis among patients diagnosed with LC in a dose-dependent manner.

Description

Source:

Keywords:

Keywords

Respiratory system, Lung cancer, Smoking, Pack-years, Prognosis, Cigarette-smoking, Tobacco smoking, Pack-years, Cessation, Disease, Risk, Survival, Cohort

Citation

Avcı, N. vd. (2017). ''Smoking habits are an independent prognostic factor in patients with lung cancer''. Clinical Respiratory Journal, 11(5), 579-584.

Endorsement

Review

Supplemented By

Referenced By

0

Views

0

Downloads