Publication:
Effect of levothyroxine treatment on clinical symptoms and serum cytokine levels in euthyroid patients with chronic idiopathic urticaria and thyroid autoimmunity

dc.contributor.buuauthorKıyıcı, Sinem Küçüksaraç
dc.contributor.buuauthorÖz Gül, Özen
dc.contributor.buuauthorBülbül Başkan, Emel
dc.contributor.buuauthorHacıoğlu, Şenay
dc.contributor.buuauthorBudak, Ferah
dc.contributor.buuauthorErtürk, Erdinç
dc.contributor.buuauthorİmamoğlu, Şazi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentİç Hastalıkları Ana Bilim Dalı
dc.contributor.departmentİmmünoloji Ana Bilim Dalı
dc.contributor.departmentDeri ve Zührevi Hastalıklar Ana Bilim Dalı
dc.contributor.orcid0000-0002-0144-3263
dc.contributor.researcheridAAH-1388-2021
dc.contributor.researcheridAAI-1005-2021
dc.contributor.researcheridF-4657-2014
dc.contributor.researcheridAAJ-6536-2021
dc.contributor.scopusid12753880400
dc.contributor.scopusid26040787100
dc.contributor.scopusid6602518817
dc.contributor.scopusid36196495300
dc.contributor.scopusid6701913697
dc.contributor.scopusid7005488796
dc.contributor.scopusid6602297533
dc.date.accessioned2022-01-20T05:37:28Z
dc.date.available2022-01-20T05:37:28Z
dc.date.issued2010-08
dc.description.abstractBackground. Screening for thyroid autoimmunity in patients with chronic idiopathic urticaria (CIU) is generally recommended. However, there are not yet sufficient data as to whether levothyroxine treatment is beneficial for the clinical symptoms of CIU in patients with thyroid autoimmunity. Aim. We investigated the effect of levothyroxine treatment on clinical symptoms and serum tumour necrosis factor (TNF)-alpha, interleukin (IL)-10 and interferon (IFN)-gamma levels in euthyroid patients with CIU and thyroid autoimmunity. Methods. In total, 15 patients with CIU and positive thyroid autoantibodies were randomized to receive either levothyroxine plus 5 mg/day desloratadine (suppression group, n = 8) or 5 mg/day desloratadine alone (control group, n = 7) for 12 weeks. Clinical symptoms of CIU, thyroid hormone levels, thyroid antibodies and serum cytokine levels were assessed at baseline and after the treatment. Results. There were significant improvements in pruritus score and severity of weals in both groups compared with baseline values, but when the two groups were compared, there was no significant difference in the patients' clinical symptoms. Thyroid antibody titres were not different according to intragroup and intergroup analysis. In the suppression group, serum IFN-gamma and TNF-alpha levels were increased after treatment with levothyroxine compared with baseline values and there was a borderline statistical significance (P = 0.05 for both). Conclusions. These results suggest that levothyroxine treatment is not a reasonable option in euthyroid patients with CIU and thyroid autoimmunity. Augmentation of cytokine production after levothyroxine treatment seems to be related to the immunomodulatory effects of TSH-suppressive treatment.
dc.identifier.citationKıyıcı, S. vd. (2010). "Effect of levothyroxine treatment on clinical symptoms and serum cytokine levels in euthyroid patients with chronic idiopathic urticaria and thyroid autoimmunity". Clinical and Experimental Dermatology, 35(6), 603-607.
dc.identifier.endpage607
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue6
dc.identifier.pubmed19874329
dc.identifier.scopus2-s2.0-77954336412
dc.identifier.startpage603
dc.identifier.urihttps://doi.org/10.1111/j.1365-2230.2009.03642.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2230.2009.03642.x
dc.identifier.urihttp://hdl.handle.net/11452/24173
dc.identifier.volume35
dc.identifier.wos000279439100007
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWiley
dc.relation.journalClinical and Experimental Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectThyroxine
dc.subjectHormones
dc.subjectHistamine
dc.subjectRelease
dc.subjectAlpha
dc.subjectDermatology
dc.subject.emtreeDesloratadine
dc.subject.emtreeGamma interferon
dc.subject.emtreeInterleukin 10
dc.subject.emtreeLevothyroxine
dc.subject.emtreeThyroglobulin antibody
dc.subject.emtreeThyroid peroxidase antibody
dc.subject.emtreeTumor necrosis factor alpha
dc.subject.emtreeAdult
dc.subject.emtreeAntibody titer
dc.subject.emtreeArticle
dc.subject.emtreeAutoimmunity
dc.subject.emtreeChronic urticaria
dc.subject.emtreeClinical article
dc.subject.emtreeClinical trial
dc.subject.emtreeControlled clinical trial
dc.subject.emtreeControlled study
dc.subject.emtreeEuthyroidism
dc.subject.emtreeFemale
dc.subject.emtreeFree liothyronine index
dc.subject.emtreeFree thyroxine index
dc.subject.emtreeHuman
dc.subject.emtreeIdiopathic disease
dc.subject.emtreeMale
dc.subject.emtreePriority journal
dc.subject.emtreePruritus
dc.subject.emtreeRandomized controlled trial
dc.subject.emtreeSymptom; thyroid autoimmunity
dc.subject.emtreeThyrotropin blood level
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAutoimmune diseases
dc.subject.meshChi-square distribution
dc.subject.meshChronic disease
dc.subject.meshDrug combinations
dc.subject.meshFemale
dc.subject.meshHistamine H1 antagonists, non-sedating
dc.subject.meshHumans
dc.subject.meshHypothyroidism
dc.subject.meshInterferon-gamma
dc.subject.meshInterleukin-10
dc.subject.meshLoratadine
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshProspective studies
dc.subject.meshThyroxine
dc.subject.meshTreatment outcome
dc.subject.meshTumor necrosis factor-alpha
dc.subject.meshUrticaria
dc.subject.meshYoung adult
dc.subject.scopusOmalizumab; Urticaria; Non-Sedating Histamine H1 Antagonists
dc.subject.wosDermatology
dc.titleEffect of levothyroxine treatment on clinical symptoms and serum cytokine levels in euthyroid patients with chronic idiopathic urticaria and thyroid autoimmunity
dc.typeArticle
dc.wos.quartileQ3
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/İç Hastalıkları Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Deri ve Zührevi Hastalıklar Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/İmmünoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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