Publication: Effect of oral antiseptics on the viral load of sars-cov-2: A randomized controlled trial
dc.contributor.author | Gül, Sema Nur Sevinç | |
dc.contributor.author | Dilsiz, Alparslan | |
dc.contributor.author | Aydın, Nurten Nur | |
dc.contributor.buuauthor | Sağlık, İmran | |
dc.contributor.buuauthor | SAĞLIK, İMRAN | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Mikrobiyoloji Ana Bilim Dalı | |
dc.contributor.orcid | 0000-0003-0699-917X | |
dc.contributor.orcid | 0000-0003-0864-4989 | |
dc.contributor.orcid | 0000-0003-4138-2490 | |
dc.contributor.researcherid | AAD-5712-2019 | |
dc.contributor.researcherid | A-4970-2019 | |
dc.date.accessioned | 2024-10-09T11:22:17Z | |
dc.date.available | 2024-10-09T11:22:17Z | |
dc.date.issued | 2022-07-29 | |
dc.description.abstract | Background. In the oral cavity, which plays an important role in the transmission of severe acute respira-tory syndrome coronavirus 2 (SARS-CoV-2), it is possible to reduce the viral load of SARS-CoV-2 with antiseptics, thereby minimizing the transmission of the virus during dental procedures.Objectives.The aim of this study was to clinically evaluate the effect of the hypochlorous acid (HClO) and povidone-iodine (PVP-I) solutions on the oral viral load of SARS-CoV-2.Material and methods.This randomized controlled trial was conducted on 75 patients hospitalized in the COVID-19 ward of a local hospital. All the patients included in the study were within the first 24 h of hospitalization and the first 5 days of coronavirus disease 2019 (COVID-19) symptoms. The viral load of mouthwash samples was measured with the cycle threshold (Ct) value of SARS-CoV-2 through a real-time reverse transcription polymerase chain reaction (RT-PCR). The patients were divided into 3 groups. The effect on the patient's SARS-CoV-2 viral load was investigated after gargling the mouths and throats for 30 s with HClO, PVP-I and isotonic saline. First, a sample was taken after gargling with isotonic saline, then another sample was taken after gargling for 30 s with a particular antiseptic to determine the viral load of SARS-CoV-2.Results. Comparing the before and after mouthwash samples from all 3 groups, there were no statistically significant differences in the Ctvalues before and after gargling (p > 0.05). However, there were statisti-cally significant differences in the number of negative samples after the use of HClO and PVP-I, which were positive before gargling (p < 0.05).Conclusions. In the light of the data obtained in this study, there is insufficient evidence that gargling with HClO or PVP-I reduces viral load. Taken together, these findings imply no role for antiseptics in the transmission of SARS-CoV-2 by the aerosol generated during dental procedures, or more generally, SARS-CoV-2 infection control. | |
dc.identifier.doi | 10.17219/dmp/150831 | |
dc.identifier.issn | 1644-387X | |
dc.identifier.uri | https://doi.org/10.17219/dmp/150831 | |
dc.identifier.uri | https://hdl.handle.net/11452/46133 | |
dc.identifier.wos | 000834886200001 | |
dc.indexed.wos | WOS.ESCI | |
dc.language.iso | en | |
dc.publisher | Wroclaw Medical Univ | |
dc.relation.journal | Dental And Medical Problems | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Hypochlorous acid | |
dc.subject | Viral load | |
dc.subject | Covid-19 | |
dc.subject | Sars-cov-2 | |
dc.subject | Hypochlorous acid | |
dc.subject | Povidone-iodine | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Dentistry, oral surgery & medicine | |
dc.subject | Medicine, general & internal | |
dc.subject | General & internal medicine | |
dc.title | Effect of oral antiseptics on the viral load of sars-cov-2: A randomized controlled trial | |
dc.type | Article | |
dc.type | Early Access | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Mikrobiyoloji Ana Bilim Dalı | |
relation.isAuthorOfPublication | aab7d5dd-72a4-4f3a-a677-1fdf3e13cadc | |
relation.isAuthorOfPublication.latestForDiscovery | aab7d5dd-72a4-4f3a-a677-1fdf3e13cadc |