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Evaluation of anti-oxidative, genotoxic and antigenotoxic potency of codium tomentosum stackhouse ethanolic extract in human lymphocytes in vitro

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dc.contributor.buuauthorÇelikler, Serap
dc.contributor.buuauthorVatan, Özgür
dc.contributor.buuauthorYıldız, Gamze
dc.contributor.buuauthorBilaloğlu, Rahmi
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentBiyoloji Bölümü
dc.contributor.orcid0000-0002-7687-3284
dc.contributor.orcid0000-0002-4177-3478
dc.contributor.researcheridA-9944-2010
dc.contributor.researcheridO-7508-2015
dc.contributor.researcheridAAH-2767-2021
dc.contributor.scopusid8234554800
dc.contributor.scopusid16235098100
dc.contributor.scopusid6701743065
dc.contributor.scopusid6505804122
dc.date.accessioned2021-12-02T12:20:09Z
dc.date.available2021-12-02T12:20:09Z
dc.date.issued2009-04
dc.description.abstractThe genome is constantly exposed to agents, both exogenous and endogenous, that damage DNA. Consequently, it is very important that determination of this agents and the protective agents. In this work, we evaluated the antigenotoxic/antimutagenic activity of the crude ethanolic extracts of Codium tomentosurn Stackhouse (Chlorophyceae) (CTE), collected from The Coast of South East Marmara Sea, in human lymphocytes culture in vitro against genotoxic/mutagenic agents MMC, EMS and H2O2 by using chromosome aberration (CA), sister chromatid exchange (SCE) and micronuclei (MN) assays as experimental endpoints. Also, in the present study, we determined total phenolic content and total antioxidant capacity (in soluble lipid and water). In addition, total protein, total carbohydrate, vitamins (A. C and E) and pigments (chlorophyll a, chlorophyll b and carotene) contents were also determined. Results of CA, SCE and MN tests show that CTEs have not shown genotoxic effect. In CTE plus MMC-. EMS- or H2O2- treated cultures, CA, SCE and MN frequency which induced by MMC, EMS or H2O2 has been decreased significantly (p < 0.05-0.001). This is the first report on genotoxicity/antigenotoxicity and anti-oxidative capacity of Codium tomentosum. Our results have clearly shown that CTE has strong anti-oxidative and antigenotoxic effect.
dc.identifier.citationÇelikler, S. vd. (2009). "Evaluation of anti-oxidative, genotoxic and antigenotoxic potency of codium tomentosum stackhouse ethanolic extract in human lymphocytes in vitro". Food and Chemical Toxicology, 47(4), 796-801.
dc.identifier.endpage801
dc.identifier.issn0278-6915
dc.identifier.issue4
dc.identifier.pubmed19167449
dc.identifier.scopus2-s2.0-60849096069
dc.identifier.startpage796
dc.identifier.urihttps://doi.org/10.1016/j.fct.2009.01.010
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0278691509000180
dc.identifier.urihttp://hdl.handle.net/11452/22967
dc.identifier.volume47
dc.identifier.wos000264623000019
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherPergamon-Elsevier Science
dc.relation.journalFood and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitakTÜBİTAK (107T279)
dc.relation.tubitakTÜBİTAK (TBAG/HD-304)
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnti-oxidative effect
dc.subjectCA
dc.subjectCodium tomentosum
dc.subjectMN
dc.subjectOxidative and chromosome damage
dc.subjectSCE
dc.subjectAntiproliferative activities
dc.subjectAntibacterial activity
dc.subjectMarine-algae
dc.subjectRed alga
dc.subjectDietary
dc.subjectSeaweed
dc.subjectDna
dc.subjectMicronuclei
dc.subjectInduction
dc.subjectProducts
dc.subjectFood science & technology
dc.subjectToxicology
dc.subjectChlorophyceae
dc.subjectCodium tomentosum
dc.subject.emtreeAlpha tocopherol
dc.subject.emtreeAscorbic acid
dc.subject.emtreeCarbohydrate
dc.subject.emtreeCarotene
dc.subject.emtreeChlorophyll a
dc.subject.emtreeChlorophyll b
dc.subject.emtreeCodium tomentosum stackhouse extract
dc.subject.emtreeHydrogen peroxide
dc.subject.emtreeLipid
dc.subject.emtreeMesylic acid ethyl ester
dc.subject.emtreeMitomycin C
dc.subject.emtreePhenol
dc.subject.emtreePlant extract
dc.subject.emtreeRetinol
dc.subject.emtreeUnclassified drug
dc.subject.emtreeWater
dc.subject.emtreeAdult
dc.subject.emtreeAntioxidant activity
dc.subject.emtreeArticle
dc.subject.emtreeCell level
dc.subject.emtreeChlorophyll content
dc.subject.emtreeChromosome aberration
dc.subject.emtreeCodium tomentosum Stackhouse
dc.subject.emtreeControlled study
dc.subject.emtreeDrug effect
dc.subject.emtreeDrug isolation
dc.subject.emtreeDrug potency
dc.subject.emtreeDrug screening
dc.subject.emtreeFemale
dc.subject.emtreeGenotoxicity
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeIn vitro study
dc.subject.emtreeLymphocyte
dc.subject.emtreeLymphocyte culture
dc.subject.emtreeMale
dc.subject.emtreeMicronucleus test
dc.subject.emtreeNormal human
dc.subject.emtreeProtein content
dc.subject.emtreeSeaweed
dc.subject.emtreeSister chromatid exchange
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAlgae, green
dc.subject.meshAntimutagenic agents
dc.subject.meshAntioxidants
dc.subject.meshChromosome aberrations
dc.subject.meshDNA damage
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLymphocytes
dc.subject.meshMale
dc.subject.meshMutagens
dc.subject.meshSister chromatid exchange
dc.subject.scopusSeaweeds; Padina; Ulva
dc.subject.wosFood science & technology
dc.subject.wosToxicology
dc.titleEvaluation of anti-oxidative, genotoxic and antigenotoxic potency of codium tomentosum stackhouse ethanolic extract in human lymphocytes in vitro
dc.typeArticle
dc.wos.quartileQ1 (Food science & technology)
dc.wos.quartileQ3 (Toxicology)
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Bölümü
local.indexed.atScopus
local.indexed.atWOS

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