Publication: Contribution of genotypes in Prothrombin and Factor V Leiden to COVID-19 and disease severity in patients at high risk for hereditary thrombophilia
dc.contributor.author | Kiraz, Aslıhan | |
dc.contributor.author | Sezer, Özlem | |
dc.contributor.author | Alemdar, Adem | |
dc.contributor.author | Canbek, Sezin | |
dc.contributor.author | Duman, Nilgün | |
dc.contributor.author | Bişgin, Atıl | |
dc.contributor.author | Cora, Tülin | |
dc.contributor.author | Ruhi, Hatice Ilgın | |
dc.contributor.author | Ergören, Mahmut Çerkez | |
dc.contributor.author | Geçkinli, Bilgen Bilge | |
dc.contributor.author | Sağ, Şebnem Özemri | |
dc.contributor.author | Gözden, Hilmi Erdem | |
dc.contributor.author | Öz, Özlem | |
dc.contributor.author | Altıntaş, Zühal Mert | |
dc.contributor.author | Yalçıntepe, Sinem | |
dc.contributor.author | Keskin, Adem | |
dc.contributor.author | Tak, Ayşegüel Yabacı | |
dc.contributor.author | Paskal, Şeyma Aktaş | |
dc.contributor.author | Yürekli, Uğur Fahri | |
dc.contributor.author | Demirtaş, Mercan | |
dc.contributor.author | Evren, Emine Ünal | |
dc.contributor.author | Hanta, Abdullah | |
dc.contributor.author | Başdemirci, Müeşerref | |
dc.contributor.author | Süer, Kaya | |
dc.contributor.author | Balta, Burhan | |
dc.contributor.author | Kocak, Nadir | |
dc.contributor.author | Karabulut, Halil Guerhan | |
dc.contributor.author | Çobanoğulları, Havva | |
dc.contributor.author | Ateş, Esra Arslan | |
dc.contributor.author | Bozdoğan, Sevcan Tuğ | |
dc.contributor.author | Eker, Damla | |
dc.contributor.author | Ekinci, Sadiye | |
dc.contributor.author | Nergiz, Sueleyman | |
dc.contributor.author | Tuncali, Timur | |
dc.contributor.author | Yagbasan, Serap | |
dc.contributor.author | Alavanda, Ceren | |
dc.contributor.author | Kutlay, Nuket Yurur | |
dc.contributor.author | Evren, Hakan | |
dc.contributor.author | Erdogan, Murat | |
dc.contributor.author | Altiner, Sule | |
dc.contributor.author | Sanlidag, Tamer | |
dc.contributor.author | Gonen, Gizem Akinci | |
dc.contributor.author | Vicdan, Arzu | |
dc.contributor.author | Eras, Nazan | |
dc.contributor.author | Eker, Hatice Kocak | |
dc.contributor.author | Balasar, Özgür | |
dc.contributor.author | Tuncel, Gulten | |
dc.contributor.author | Dündar, Munis | |
dc.contributor.author | Gürkan, Hakan | |
dc.contributor.buuauthor | ALEMDAR, ADEM | |
dc.contributor.buuauthor | ÖZEMRİ SAĞ, ŞEBNEM | |
dc.contributor.buuauthor | TEMEL, ŞEHİME GÜLSÜN | |
dc.contributor.buuauthor | Gozden, Hilmi Erdem | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Translasyonel Tıp Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı. | |
dc.contributor.researcherid | ELA-3536-2022 | |
dc.contributor.researcherid | IYV-1877-2023 | |
dc.contributor.researcherid | JMQ-2372-2023 | |
dc.contributor.researcherid | IRT-7350-2023 | |
dc.date.accessioned | 2024-07-01T12:04:51Z | |
dc.date.available | 2024-07-01T12:04:51Z | |
dc.date.issued | 2023-02-01 | |
dc.description.abstract | Thrombotic and microangiopathic effects have been reported in COVID-19 patients. This study examined the contribution of the hereditary thrombophilia factors Prothrombin (FII) and Factor V Leiden (FVL) genotypes to the severity of COVID-19 disease and the development of thrombosis. This study investigated FII and FVL alleles in a cohort of 9508 patients (2606 male and 6902 female) with thrombophilia. It was observed that 930 of these patients had been infected by SARS-CoV-2 causing COVID-19. The demographic characteristics of the patients and their COVID-19 medical history were recorded. Detailed clinical manifestations were analyzed in a group of cases (n = 4092). This subgroup was age and gender-matched. FII and FVL frequency data of healthy populations without thrombophilia risk were obtained from Bursa Uludag University Medical Genetic Department's Exome Databank. The ratio of males (31.08%; 27.01%) and the mean age (36.85 & PLUSMN; 15.20; 33.89 & PLUSMN; 14.14) were higher among COVID-19 patients compared to non-COVID-19 patients. The prevalence of FVL and computerized tomography (CT) positivity in COVID-19 patients was statistically significant in the thrombotic subgroup (p < 0.05). FVL prevalence, CT positivity rate, history of thrombosis, and pulmonary thromboembolism complication were found to be higher in deceased COVID-19 patients (p < 0.05). Disease severity was mainly affected by FVL and not related to genotypes at the Prothrombin mutations. Overall, disease severity and development of thrombosis in COVID-19 are mainly affected by the variation within the FVL gene. Possible FVL mutation should be investigated in COVID-19 patients and appropriate treatment should be started earlier in FVL-positive patients. | |
dc.identifier.doi | 10.1002/jmv.28457 | |
dc.identifier.issn | 0146-6615 | |
dc.identifier.issue | 2 | |
dc.identifier.uri | https://doi.org/10.1002/jmv.28457 | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/jmv.28457 | |
dc.identifier.uri | https://hdl.handle.net/11452/42662 | |
dc.identifier.volume | 95 | |
dc.identifier.wos | 001034949300128 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.relation.journal | Journal of Medical Virology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Sars-cov-2 infection | |
dc.subject | Frequency | |
dc.subject | Population | |
dc.subject | G20210a | |
dc.subject | Covid-19 | |
dc.subject | Factor v leiden | |
dc.subject | Prothrombin | |
dc.subject | Thrombophilia | |
dc.subject | Virology | |
dc.title | Contribution of genotypes in Prothrombin and Factor V Leiden to COVID-19 and disease severity in patients at high risk for hereditary thrombophilia | |
dc.type | Article | |
dspace.entity.type | Publication | |
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