Publication:
Fetal substantia nigra grafts-effect on dopamine receptors in the rat corpus striatium

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dc.contributor.authorKnowles, W. D.
dc.contributor.authorÖzmen, Tolga
dc.contributor.buuauthorKorfalı, Ender
dc.contributor.buuauthorUlus, Hakkı İ.
dc.contributor.buuauthorUysal, Sait
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmakoloji Ana Bilim Dalı
dc.contributor.departmentBeyin Cerrahisi Ana Bilim Dalı
dc.contributor.researcheridD-5340-2015
dc.date.accessioned2021-07-12T11:28:54Z
dc.date.available2021-07-12T11:28:54Z
dc.date.issued1989
dc.description.abstractEffects of fetal substantia nigra grafts on the dopamine receptors in the corpus striatum in rats were investigated after the destruction of the nigrostriatal dopaminergic pathways with intraventricular 6-hydroxydopamine injections. The expected dopamine receptor denervation supersensitivity was demonstrated by a 53.7% increase of [3H]spiroperidol binding in rats with sham grafts compared with normal control-group rats. In contrast, rats with grafts showed a significant reduction of supersensitivity, with a 25% decrease in binding to the graft-bearing caudate when compared with the sham-graft group. A nonsignificant 15% decrease in binding on the nongrafted side was also observed. The fetal substantia nigra grafts thus reduced the denervation supersensitivity toward a normal level.
dc.identifier.citationKorfalı, E. vd. (1989). ''Fetal substantia nigra grafts-effect on dopamine receptors in the rat corpus striatium''. Cleveland Clinic Journal of Medicine, 56(3), 259-262.
dc.identifier.endpage262
dc.identifier.issn0891-1150
dc.identifier.issue3
dc.identifier.pubmed2568188
dc.identifier.scopus2-s2.0-0024934954
dc.identifier.startpage259
dc.identifier.urihttps://doi.org/10.3949/ccjm.56.3.259
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/2568188/
dc.identifier.urihttp://hdl.handle.net/11452/21221
dc.identifier.volume56
dc.identifier.wosA1989U830100008
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherCleveland Clinic
dc.relation.collaborationYurt dışı
dc.relation.collaborationYurt içi
dc.relation.journalCleveland Clinic Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGeneral & internal medicine
dc.subjectSubstantia nigra
dc.subjectAnimal experiment
dc.subjectArticle
dc.subjectBrain graft
dc.subjectCorpus striatum
dc.subjectFetusat
dc.subjectNonhuman
dc.subjectRat
dc.subjectNonhuman
dc.subject.wosMedicine, general & internal
dc.titleFetal substantia nigra grafts-effect on dopamine receptors in the rat corpus striatium
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Beyin Cerrahisi Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Farmakoloji Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

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