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Comprehensive assessment of candidate genes associated with fattening performance in Holstein-Friesian bulls

dc.contributor.buuauthorArdıçlı, Sena
dc.contributor.buuauthorŞamlı, Hale
dc.contributor.buuauthorVatansever, Buse
dc.contributor.buuauthorSoyudal, Bahadır
dc.contributor.buuauthorDinçel, Deniz
dc.contributor.buuauthorBalcı, Faruk
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentZootekni ve Hayvan Besleme Bölümü
dc.contributor.orcid0000-0003-2758-5945
dc.contributor.orcid0000-0003-2382-1330
dc.contributor.researcheridAAM-4361-2020
dc.contributor.researcheridAAH-6488-2021
dc.contributor.researcheridO-3394-2019
dc.contributor.researcheridAAH-6192-2021
dc.contributor.scopusid56607305700
dc.contributor.scopusid6507670789
dc.contributor.scopusid57203938885
dc.contributor.scopusid56607355300
dc.contributor.scopusid56607385000
dc.contributor.scopusid16062981700
dc.date.accessioned2023-01-31T06:02:53Z
dc.date.available2023-01-31T06:02:53Z
dc.date.issued2019-01-10
dc.description.abstractThe objective of this study was to determine the association of single nucleotide polymorphisms (SNPs) in selected candidate genes with fattening performance traits in a commercial cattle herd. Fifteen SNPs in 12 candidate genes (LEP, FABP4, DGAT1, TG, IGF1, IGF1R, MYF5, LGB, CAPN1, CAST, GHR, and OLR1) were evaluated in 296 purebred Holstein-Friesian bulls using PCR-RFLP (polymerase chain reaction - restriction fragment length polymorphism). Associations between each segregating SNP and genetic merit for fattening performance were quantified using linear mixed models. Traits included in the study were fattening period, final weight, dry matter intake, feed conversion rate, and average daily weight gain. Apart from the general determination of the above-mentioned traits, each trait was evaluated based on the fattening periods between five selected target body weights (W1 = 100 kg, W2 = 200 kg, W3 = 300 kg, W4 = 400 kg, W5 = 450 kg). All markers with the exception of CAPN1 530, IGF1R, TG, and DGAT1 were associated with at least one of the traits. Furthermore, novel associations were observed for LEP x GHR, IGF1 x LEP, FABP4 3691 x FABP4 2834, and FAP4 3533 x LEP interactions. The results of this study confirm some previously reported associations. Moreover, novel associations have been identified, which may be incorporated into breeding programs to improve fattening performance.
dc.identifier.citationArdıçlı, S. vd. (2019). ''Comprehensive assessment of candidate genes associated with fattening performance in Holstein-Friesian bulls''. Archives Animal Breeding, 62(1), 9-32.
dc.identifier.endpage32
dc.identifier.issn0003-9438
dc.identifier.issn2363-9822
dc.identifier.issue1
dc.identifier.pubmed31807610
dc.identifier.scopus2-s2.0-85060365475
dc.identifier.startpage9
dc.identifier.urihttps://doi.org/10.5194/aab-62-9-2019
dc.identifier.urihttps://aab.copernicus.org/articles/62/9/2019/aab-62-9-2019.pdf
dc.identifier.urihttp://hdl.handle.net/11452/30722
dc.identifier.volume62
dc.identifier.wos000456308500001
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherCopernicus Publications
dc.relation.journalArchives Animal Breeding
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAgriculture
dc.subjectQuantitative trait loci
dc.subjectMeat quality traits
dc.subjectSingle nucleotide polymorphisms
dc.subjectGrowth-hormone receptor
dc.subjectEstimated breeding values
dc.subjectBovine leptin gene
dc.subjectCarcass characteristics
dc.subjectBeef-cattle
dc.subjectFabp4 gene
dc.subjectSnp marker
dc.subject.scopusCalpastatin; Meat Tenderness; Single Nucleotide Polymorphism
dc.subject.wosAgriculture, dairy & animal science
dc.titleComprehensive assessment of candidate genes associated with fattening performance in Holstein-Friesian bulls
dc.typeArticle
dc.wos.quartileQ3
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/Zootekni ve Hayvan Besleme Bölümü
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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