Publication:
Altered expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the formation of chronic Brucellosis

dc.contributor.buuauthorBudak, Ferah
dc.contributor.buuauthorBal, Salih Haldun
dc.contributor.buuauthorTezcan, Gülçin
dc.contributor.buuauthorAkalın, Halis
dc.contributor.buuauthorGöral, Güher
dc.contributor.buuauthorOral, Haluk Barbaros
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentİmmünoloji Ana Bilim Dalı
dc.contributor.departmentKlinik Mikrobiyoloji ve Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.contributor.departmentTıbbi Mikrobiyoloji Ana Bilim Dalı
dc.contributor.departmentTıbbi Biyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0003-0463-6818
dc.contributor.orcid0000-0002-5956-8755
dc.contributor.researcheridK-7285-2012
dc.contributor.researcheridAAU-8952-2020
dc.contributor.researcheridF-4657-2014
dc.contributor.researcheridF-8554-2017
dc.contributor.researcheridAAH-3843-2020
dc.contributor.scopusid6701913697
dc.contributor.scopusid57191480128
dc.contributor.scopusid25650627600
dc.contributor.scopusid57207553671
dc.contributor.scopusid6603453166
dc.contributor.scopusid7004498001
dc.date.accessioned2022-11-22T10:21:05Z
dc.date.available2022-11-22T10:21:05Z
dc.date.issued2016-07-31
dc.description.abstractBrucellosis is a zoonotic disease that is still endemic in developing countries. Despite early diagnosis and treatment of patients, chronic infections are seen in 10-30% of patients. In this study, we aimed to investigate the immunological factors that play roles in the transition of brucellosis from acute infection into chronic infection. Here, more than 2000 miRNAs were screened in peripheral blood mononuclear cells (PBMCs) of patients with acute or chronic brucellosis and healthy controls by using miRNA array, and the results of the miRNA array were validated through qRT-PCR. Findings were evaluated using GeneSpring GX (Agilent) 13.0 software and KEGG pathway analysis. Four miRNAs were expressed in the chronic group but were not expressed in acute and control groups. Among these miRNAs, the expression level of miR-1238-3p was increased while miR-494, miR-6069, and miR-1393p were decreased (p< 0.05, fold change > 2). These miRNAs have the potential to be markers for chronic cases. The differentially expressed miRNAs and their predicted target genes involved in endocytosis, regulation of actin cytoskeleton, MAPK signaling pathway, and cytokine-cytokine receptor interaction and its chemokine signaling pathway indicate their potential roles in chronic brucellosis and its progression. It is the first study of miRNA expression analysis of human PBMC to clarify the mechanism of inveteracy in brucellosis.
dc.identifier.citationBudak, F. vd. (2016). "Altered expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the formation of chronic Brucellosis". Journal of Immunology Research, 2016, 1-11.
dc.identifier.endpage11
dc.identifier.issn2314-8861
dc.identifier.issn2314-7156
dc.identifier.pubmed27722176
dc.identifier.scopus2-s2.0-84990876577
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1155/2016/4591468
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046029/
dc.identifier.urihttp://hdl.handle.net/11452/29535
dc.identifier.volume2016
dc.identifier.wos000385116100001
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherHindawi
dc.relation.journalJournal of Immunology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitakSBAG-111S183
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectImmunology
dc.subjectDendritic cell maturation
dc.subjectB-virus infection
dc.subjectMicrorna expression
dc.subjectGene-expression
dc.subjectUp-regulation
dc.subjectIntegrated analysis
dc.subjectAbortus invasion
dc.subjectDown-regulation
dc.subjectCancer cells
dc.subjectTNF-alpha
dc.subject.emtreeCytokine
dc.subject.emtreeDoxycycline
dc.subject.emtreeMicroRNA
dc.subject.emtreeMicrorna 1238 3p
dc.subject.emtreeMicrorna 139 3p
dc.subject.emtreeMicrorna 1914 3p
dc.subject.emtreeMicrorna 22 5p
dc.subject.emtreeMicrorna 335 5p
dc.subject.emtreeMicrorna 339 5p
dc.subject.emtreeMicrorna 494
dc.subject.emtreeMicrorna 575
dc.subject.emtreeMicrorna 6069
dc.subject.emtreeMitogen activated protein kinase
dc.subject.emtreeRifampicin
dc.subject.emtreeUnclassified drug
dc.subject.emtreeBiological marker
dc.subject.emtreeMIRN1238 microRNA, human
dc.subject.emtreeMIRN139 microRNA, human
dc.subject.emtreeMIRN494 microRNA, human
dc.subject.emtreeActin filament
dc.subject.emtreeAdult
dc.subject.emtreeArticle
dc.subject.emtreeBrucellosis
dc.subject.emtreeChronic brucellosis
dc.subject.emtreeChronicity
dc.subject.emtreeClinical article
dc.subject.emtreeControlled study
dc.subject.emtreeDisease course
dc.subject.emtreeEndocytosis
dc.subject.emtreeFatigue
dc.subject.emtreeFemale
dc.subject.emtreeGene expression
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeImmune response
dc.subject.emtreeMale
dc.subject.emtreePeripheral blood mononuclear cell
dc.subject.emtreeProtein protein interaction
dc.subject.emtreeReverse transcription polymerase chain reaction
dc.subject.emtreeSignal transduction
dc.subject.emtreeAcute disease
dc.subject.emtreeBlood
dc.subject.emtreeBrucellosis
dc.subject.emtreeChronic disease
dc.subject.emtreeGene expression profiling
dc.subject.emtreeGenetics
dc.subject.emtreeImmunology
dc.subject.emtreeMetabolism
dc.subject.emtreeMicrobiology
dc.subject.emtreeMiddle aged
dc.subject.emtreeReal time polymerase chain reaction
dc.subject.meshAcute disease
dc.subject.meshBiomarkers
dc.subject.meshBrucellosis
dc.subject.meshChronic disease
dc.subject.meshFemale
dc.subject.meshGene expression profiling
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMetabolic networks and pathways
dc.subject.meshMicroRNAs
dc.subject.meshMiddle aged
dc.subject.meshReal-time polymerase chain reaction
dc.subject.scopusAnimals; Zoonosis; Bovine Brucellosis
dc.subject.wosImmunology
dc.titleAltered expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the formation of chronic Brucellosis
dc.typeArticle
dc.wos.quartileQ2
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/İmmünoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Tıbbi Biyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Klinik Mikrobiyoloji ve Enfeksiyon Hastalıkları Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Tıbbi Mikrobiyoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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