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Permanent URI for this collectionhttps://hdl.handle.net/11452/21452
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Browsing by Department "Beyin ve Sinir Cerrahisi Ana Bilim Dalı"
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Publication Anatomical study of the cavernous sinus emphasizing operative approaches(Türk Nöroşirürji Derneği, 2010-04) Boyacı, Suat; Aksoy, Kaya; Dalgıç, Adem; Tıp Fakültesi; Beyin ve Sinir Cerrahisi Ana Bilim Dalı; 36135211700AIM: The aim of this article is to describe the microsurgical anatomy of the cavernous sinus, the triangles, and the osseous relationships in the region with special attention to the relationships important in surgical approaches on the intracavernous structures. MATERIAL and METHODS: Fifty cavernous sinuses obtained from twenty-five cadaver heads were studied in detail using magnification. Stepwise dissections of the cavernous sinuses performed to demonstrate the intradural and extradural routes, anatomy of the triangles and osseous relationships in the region. RESULTS: The main branches of the intracavernous portion of the carotid artery were the meningohypophyseal, the inferior cavernous sinus, and McConnell's capsular artery. The main branches of the meningohypophyseal trunk were the tentorial, the dorsal meningeal, and the inferior hypophyseal artery. There were variations of the main branches of the meningohypophyseal trunk. The sixth cranial may splite into rootlets as it passes lateral to the carotid artery. There were size and shape variation of the triangles. CONCLUSION: A precise understanding of the bony relationships, the anatomy of the triangels and neurovascular content of the cavernous sinus, together with the use of cranial base and microsurgical techniques are necessary for safer surgery. A single approach is not capable of providing exposure of all parts of the sinus.Publication Cholesterol granuloma in the petrous apex: A case report(Ege Üniversitesi Tıp Fakültesi, 2010) Doğan, Şeref; Özcan, Tekin; Şahin, Soner; Tıp Fakültesi; Beyin ve Sinir Cerrahisi Ana Bilim Dalı; AAI-6531-2021; 7102693077; 25636374000; 8272141000A-72-year-old man admitted with the complaint of mild right facial numbness and headache. His neurological examination revealed facial paresthesia on the right over the distribution of second division of the trigeminal nerve. Computed tomographic and magnetic resonance imaging showed an expansive lesion in the right petrous apex. The patient underwent surgery via right suboccipital retrosigmoid approach and the tumor was totally removed. Microscopic examination revealed a cholesterol granuloma. The suboccipital approach can be safely used in cases which have lesions invading posterior fossa and causing the clinical picture.Publication Investigation of the dose-dependency of citicoline effects on nerve regeneration and functional recovery in a rat model of sciatic nerve injury(Türk Nöroloji Derneği, 2014-01) Kaplan, Tolga; Kafa, İlker Mustafa; Cansev, Mehmet; Bekar, Ahmet; Karlı, Necdet; Taşkapılıoğlu, Mevlüt Özgür; Kanar, Fulya; Tıp Fakültesi; Beyin ve Sinir Cerrahisi Ana Bilim Dalı; 0000-0001-5472-9065; AAW-5254-2020; AAG-7125-2021; M-9071-2019; 7006761497; 8450193200; 8872816100; 6603677218; 6506587942; 25936798300; 56037464100AIM: The aim of this study was to investigate the dose dependence of citicoline's previously-reported effects on recovery of peripheral nerve injury. MATERIAL and METHODS: Right sciatic nerves of sixty adult female Wistar Albino rats were incised and primary anastomosis was performed. Rats were then divided into four groups: Control group received 2 ml of saline intraperitoneally, while rats in C-300, C-600 and C-900 groups received 300 mu mol/kg, 600 mu mol/kg and 900 mu mol/kg citicoline dissolved in 2 ml saline, respectively. Rats were tested for sciatic functional index (SFI) on the 4th, 8th and 12th weeks and electrophysiological recordings were obtained on the 12th week. Rats were then sacrificed to investigate nerve adhesions and perform histomorphological examinations. RESULTS:Our results showed that rats in C-600 and C-900 groups had significantly lesser neural adhesion and greater SFI and electrophysiological score than those in the Control and C-300 groups (p<0.05). Mean density and total number of functionally myelinated axons were significantly increased in C-900 group, while perineural scar tissue formation was reduced in all citicoline-treated groups. CONCLUSION: We conclude that citicoline exhibits dose-dependent effects on axonal regeneration and recovery without scar formation in a rat model of peripheral nerve incision and primary anastomosis.