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1998-2005 yılları arasında Türkiye'de 5 farklı bölgedeki üniversitelerin Adli Tıp Anabilim dallarında raporladırılan yaş tayini olgularının i̇rdelenmesi
(Ortadoğu Yayınları, 2009-04) Baransel, Aysun; Büken, Bora; Tokdemir, Mehmet; Dülger, Hikmet Ergin; Erel, Özlem; Fedakar, Recep; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; AAH-6287-2021; 8725968900
Adli tıpta yaş tayini, gerek canlıda gerekse ölüde kimlik tespitinde yaygın olarak kullanılmakta ve cezai ve hukuki sorumluluğun belirlenmesinde çok önemli bir yer tutmaktadır. Yaş tayininde, günlük uygulamada sıklıkla kullanılan yöntem, fiziksel muayene ile birlikte, kemik gelişiminin radyolojik olarak görüntülenmesi ve hazırlanmış atlaslara uyarlanarak kemik yaşının tespiti esasına dayanmaktadır. Çalışmamızda Türkiye’de yaş tayininde yaygın olarak kullanılan ve 5 ayrı coğrafi bölgede bulunan Gaziantep, Fırat, Adnan Menderes, Uludağ ve Düzce Üniversitelerinin Adli Tıp Anabilim Dalı Başkanlıkları tarafından da kıstas alınan “Gök Atlası”na göre yaş verilerinin değerlendirilerek irdelenmesi amaçlanmıştır. Gereç ve Yöntemler: Bu çalışmada, 1998-2005 tarihleri arasında çeşitli nedenlerle mahkeme tarafından yaş tayini istenen 275’i erkek, 312’si kadın toplam 587 olgu değerlendirmeye alındı. Radyolojik inceleme ile çeşitli yaş gruplandırılmaları yapılarak kronolojik yaş ve kemik yaşı arasındaki uyum veya farklılık olup olmadığı araştırıldı. Bulgular: 0-12 yaş grubuna giren 39 olgunun 31 (%79.5)’inin kemik yaşı kronolojik yaşından büyük, 6 (%15.4)’sının kemik yaşı kronolojik yaşı ile uyumlu ve 2 (%5.1)’sinin kemik yaşı kronolojik yaşından küçük bulundu. 13-22 yaş grubunda kronolojik yaşa göre ileri düzeyde kemik gelişimi olguların %79.8’inde, kronolojik yaşa göre geri kalmış kemik gelişimi %9.6’sında ve kemik ve kronolojik yaş uyumu %10.6’sında tespit edildi. Sonuç: Bu çalışmada, puberte dönemindeki fiziksel gelişmenin kemik gelişimi üzerindeki önemli etkisi ve kesin yaş tayini yapılamayan puberte sonrası ileri yaşlarda yeni ve gelişmiş tekniklerin rutin uygulamada kullanılması gerektiği vurgulandı. Özellikle toplumumuza özgü atlasın bir an önce hazırlanması gerektiği sonucuna varıldı.
Acute poisoning in adults in the years 1996-2001 treated in the Uludag University Hospital, Marmara region, Turkey
(Taylor & Francis, 2005) Akkose, Sule Aydin; Bulut, Mehmet Turker; Armagan, Emrah; Cebicci, Huseyin; Fedakar, Recep; Tıp Fakültesi; Acil Tıp Ana Bilim Dalı; 0000-0002-8987-6484; AAH-6287-2021
Background. Acute poisonings are frequent causes of admission to emergency departments and these cases may have hazardous outcomes. Methods. In the present study, medical records of 1818 poisoned patients admitted to Uludag University Medical School's Emergency Department between January 1996 and December 2001 were investigated. The age, sex, outcomes of the patients, and type of poisoning are described. Results. The mean age for females (63% of the patients) was 27 years, whilst the mean age of male patients was 31 years. The major types of poisonings were ingestions of medications (59.6%), mushrooms (3.3%), corrosives (2.5%), organophosphates (3.2%), and methyl alcohol (0.4%). Carbon monoxide accounted for 6.9% of intoxications. Approximately 65% of the patients survived, while the methyl alcohol and corrosive ingestions led to the highest fatality averages (100% and 14.8%, respectively). Conclusions. The demographic and diagnostic features of acute poisoning cases treated in our hospital are similar to those reported in the literature. Adults and women are in a high-risk group for acute poisonings and medicine poisoning, which is the most common type of poisoning.
ADAMTS4, 5, 9, and 15 expressions in the autopsied brain of patients with Alzheimer’s disease: A preliminary immunohistochemistry study
(Küre İletişim Grubu, 2015-07-06) Pehlivan, Sultan; Eren, Bülent; Akyol, Sümeyya; Eren, Filiz; Tagil, Süleyman Murat; Demircan, Kadir; Fedakar, Recep; İnanır, Nursel Türkmen; Gürses, Murat Serdar; Ural, Mustafa Numan; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0002-9982-0476; AAC-8913-2020; AAH-6287-2021; 8725968900; 56712925300; 55979536300; 57163358100
Objective: Recent studies performed in the central nervous system highlight the pathophysiological relevance of A disintegrin-like and metalloproteinase with thrombospondin motifs (ADAMTS) genes and their protein products. The determination of alterations in expression profiles of ADAMTS family genes in Alzheimer's disease (AD) patients may contribute to the explanation of tissue pathology and also new ideas for remedial approaches for this incurable but preventable disease. Therefore, the goal of this study was to describe and identify the distribution, characteristics, and any changes in the expression, in other words, immunoreactivity, for aggrecanases (ADAMTS4, 5, 9, and 15) proteins in AD brain. Methods: Nine cases that were autopsied in the Council of Forensic Medicine, Bursa Morgue Department in 2013, were selected. All of the cases were sent for autopsy to the institution within 8 hours after death. At autopsy, tissue samples were obtained for histopathological examination of organs for determining the cause of death. Out of these, two cases were diagnosed with AD by neurologists when they were alive. Immunohistochemical staining was performed on the brain slides by using relevant primary and secondary antibodies against aggrecanase proteins. All images were acquired using a X200 objective of a microscope (Olympus BX53) and evaluated by the staining intensity using a semi-quantitative scoring system. Results: ADAMTS4 and 5 were slightly under-expressed in the brains from autopsied AD cases compared to those of control brains and suggested that extracellular matrix (ECM) degradation was not endorsed in AD brain. On the other hand, ADAMTS9 and 15 aggrecanases were not found to be expressed in correspondent brain sections of AD and control cases. Conclusion: The current study demonstrated that some aggrecanases were found to be under-expressed in AD brains. Additional studies in which all ADAMTS enzymes will be studied in terms of mRNA and protein levels are needed to understand the relative contributions of ADAMTS genes and proteins in AD brains.
Age-related changes in the rat hippocampus
(Elsevier, 2008-05) İş, Merih; Comunoğlu, Cem; Ekici, Işın Doğan; Özkan, Ferda; Comunoğlu, Nil; Eren, Bülent; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0002-2319-1757; AAU-7408-2020; AAK-8096-2021; AAX-8590-2021; 8725969000
The human brain is uniquely powerful in its cognitive abilities, yet the hippocampal and neocortical circuits that mediate these complex functions are highly vulnerable during aging. In this study, we analyzed age-related changes in the rat hippocampus by studying newborn (1 month), middle-aged (12 months), and older (24 months) male and female Sprague-Dawley rats. We evaluated neuronal dystrophy, neuron scattering, and granulovacuolar degeneration in the hippocampal area using light microscopy, according to age and gender. We detected significant neuronal dystrophy in the CA1, CA2, and CA3 areas in male rats, and in the CA1, CA3, and CA4 areas in female rats. Degenerative changes, indicated by neuron scattering, were observed in the CA1, CA2, and CA3 areas of male and the CA2 and CA4 areas of female rats. Changes in all areas of the hippocampus were observed with increasing age; these changes included neuronal dystrophy and neuron scattering and did not differ significantly between male and female rats.
Age-related histopathological changes in the cardiac conducting system in the Turkish population: An evaluation of 202 autopsy cases
(Via Medica, 2012-08) Çomunoğlu, Cem; Çomunoğlu, Nil; Eren, Bülent; Tanrıöver, Özlem; Gündoǧmuş, Ümit Naci; Eren, Filiz; Türkmen, Nursel; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 8715251700
Background: Histopathological features of the cardiac conducting system (CCS) in the Turkish population have not been investigated previously. Material and methods: We examined CCS of 202 autopsy heart specimens dissected between the years 2004 and 2005 in Bursa Forensic Medicine Institution. Of the 202 cases from all age groups, 154 were males and 48 were females. Results: In our cases, an increase in fibrous and adipose tissue concordant with age, indicating an age-related nature, were detected. Fibrous and fatty tissue infiltration appeared at the age of 35. Fatty infiltration started between the ages 20 and 34 years at the sinoatrial node (SAN). There was no relationship between obesity and fatty tissue infiltration in SAN and atrioventricular node (AVN). In 4 cases calcification and in 19 cases inflammation was observed. Amyloid accumulation was not present. In 7 cases myocardial infarction not involving CCS was seen. In 1 case fibroelastoma was detected. Conclusions: In the Turkish population age-related fibrosis and fatty infiltration in CCS appeared at the age of 35 years and increased with age. Fatty infiltration in the SAN started at a younger age than that reported in the literature. In cases where the cause of death could not be determined, we could not detect lethal pathological features. However, we think that examination of the CCS will improve the quality of autopsy diagnosis.
Allergic myocardial infarction due to hydatid cyst: An autopsy case
(Comenius University, 2010) Eren, Bülent; Türkmen, Nursel; Fedakar, Recep; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0002-8296-5484; AAH-6287-2021; AAK-8096-2021; 8725969000; 8715251700; 8725968900
Hydatid disease is a parasitic tapeworm infestation. Anaphylactic reactions as a result of cyst perforation generally occur after trauma during a spread of cystic fluid in the intravascular space, which may also initiate anaphylaxis. The reported case was a 17-year-old boy who was admitted to the hospital emergency department with a sudden onset of nausea, vomiting and fainting, resulting in death. The cause of his sudden death was unknown. Autopsy macroscopically revealed hydatid cysts in the liver. In the histopathological examination, hydatid cyst was recognized by scolices and also an inflammatory infiltration composed mainly of mast cells in the myocardium was detected. Sudden death in this case was attributed to allergic myocardial infarction due to intravascular spread of the hydatid cyst content
Black esophagus: A rare autopsy case
(Comenius University, 2010) Eren, Bülent; Türkmen, Nursel; Fedakar, Recep; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; AAH-6287-2021; 8715251700; 8725968900
The black esophagus is a rare entity of an acute esophageal necrosis described at endoscopy and typical histological properties of a diffuse mucosal necrosis. The presented case was a 17 year-old girl; admitted to the hospital with an abdominal distantion and vomiting, who died soon after admittance. The case was investigated by local prosecutor, as the cause of the death was unknown; a forensic autopsy was mandated and later performed in our department. During autopsy on macroscopic examination an acute esophageal necrosis with black colored esophageal mucosa was detected. In this case report, we aimed to explain the autopsy findings, clinical presentation, histological appearance, risk factors and pathogenesis of the disease from the medico legal point of view
Cardiac rupture due to fall: A case study
(Acad Medicine Singapore, 2009-02) Eraslan, Berna Şenel; Türkmen, Nursel; Bilgen, Muhammed Sadık; Eren, Bülent; Fedakar, Recep; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0002-8296-5484; AAH-6287-2021; AAK-8096-2021; 8715251700; 35723877700; 8725969000; 8725968900
Studies have shown that cardiac ruptures due to blunt trauma are seen more often than expected. However, epicardial injuries and atrial ruptures are common findings in deaths due to falls. Our aim is to present a unique, isolated cardiac rupture in a 1 year-old child resulting from a fall from a bed, to evaluate autopsy findings among the literature from a medico-legal point of view.
Cardiac rupture following blunt trauma
(Wiley, 2001-01-01) Durak, Dilek; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0003-3469-340X; AAH-6587-2021; 56700124800
A case of cardiac rupture following blunt trauma with no additional injuries is described. This can be a difficult diagnosis because of the presence of additional injuries and the lack of clinical symptoms. Here, there was a rupture of the pericardium, all chambers of the heart and the thoracic aorta.
A case report of fatal oral ingestion of resorcinol
(Wiley-Blackwell, 2006-11) Bulut, Mehtap; Türkmen, Nursel; Fedakar, Recep; Aydın, Şule Akköse; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; AAH-6287-2021; 35783913800; 8715251700; 8725968900; 6603347542
Resorcinol is a pharmaceutical agent used topically in dermatological treatments for acne, eczema, psoriasis and related skin conditions. Although there are a few studies that indicate chronic toxic effects of resorcinol on humans after topical application, information on the effects of resorcinol in acute poisoning after oral ingestion is limited. Thus, we wish to report the clinical and laboratory findings of a patient who was admitted to our emergency department (ED) after inadvertent oral ingestion of resorcinol and later died, as well as the patient's autopsy findings. The major clinical and laboratory findings were unconsciousness, respiratory failure that required mechanical ventilation, generalized tonic-clonic seizures, leukocytosis and severe metabolic acidosis. In the blood sample taken at the autopsy, a high level of methemoglobin was found. In the serum, resorcinol was revealed by gas chromatography-mass spectrometry. It can be concluded that the basic approach to patients with resorcinol poisoning should include initial stabilization of the patient by supporting the airway, respiration and circulation, and treating complications such as seizures or metabolic acidosis in the ED, as soon as possible after oral ingestion.
The characteristics of suicidal cases regarding the gender
(TÜBİTAK, 2009-12) Odabaşı, Aysun Balseven; Tümer, Ali Rıza; Türkmen, Nursel; Fedakar, Recep; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; AAH-6287-2021; 8715251700; 8725968900
Aim: We studied the patterns of suicide in forensic autopsies performed in Bursa province of Turkey to determine gender differences, incidence of suicide, subgroups of the population most vulnerable to,such deaths, and suicide methods used. Materials and methods: Nine hundred fifty-five death cases due to suicide underwent forensic autopsy between 1996 and 2005 in Bursa were included into the study. All of the cases were analyzed in terms of age, gender, and method of suicide, time of year, and alcohol use. Results were subjected to discriminant analyses using SPSS 11.0. Results: There were 955 cases, with 682 males (12-95 years; mean, 41.2 years) and 273 females (10101 years; mean, 33.1 years). For both genders, the most common method was hanging, accounted for 51.6% of the cases. Firearm injuries were more frequent in males than in females while insecticide poisoning, falling from height, and drug poisoning were more commonly used methods in females compared to males (P < 0.001), following hanging. Conclusion: In our study there was a significant difference between men and women in terms of suicide age and suicide method. More research studies are needed on gender differences in suicidal behavior to develop prevention strategies.
Clusterin expression in non-neoplastic adenohypophyses and pituitary adenomas: Cytoplasmic clusterin localization in adenohypophysis is related to aging
(Humana Press, 2008) Ekici, Asiye Isin Dogan; Çomunoğlu, Nil; Eren, Bülent; Türkmen, Nursel; Fedakar, Recep; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0002-2319-1757; AAA-6280-2020; AAU-7408-2020; AAK-8096-2021; AAX-8590-2021; AAX-8590-2021; 8725969000; 8715251700; 8725968900
Clusterin is a circulating multifunctional glycoprotein produced in several kinds of epithelial and neuronal cells. Clusterin is upregulated during different physiological and pathological states, such as senescence, type-2 diabetes mellitus, Alzheimer disease, and in various neoplasms. Herein, we investigated the immunohistochemical expression of clusterin in non-neoplastic adenohypophysis of human autopsy subjects and pituitary adenomas. We also investigated the association of clusterin increase with age in adenohypophysis of autopsy subjects. Immunohistochemically, clusterin was found positive in the cytoplasm of all adenoma cases, and in the cytoplasm of parenchymal cells, stellate cells, mixed cell follicles and in colloidal material inside of the follicles of non-neoplastic adenohypophysis as well. Clusterin expression in pituitary adenomas was found significantly higher than in non-neoplastic adenohypophyses. In addition, in non-neoplastic adenohypophysis, a significant increase in clusterin expression levels between young (<= 30 years), middle aged (31 to 60 years), and older (>= 61 years) subjects (p<0.00001, analysis of variance [ANOVA]) was found. In addition to clusterin accumulation, presence of calcification (p<0.045, ANOVA) and presence of large follicles with colloid accumulation (p< 0.004, ANOVA) were also statistically significant factors related to aging in non-neoplastic adenohypophysis. In conclusion, the present study demonstrated that clusterin expression was found in non-neoplastic adenohypophysis and in upregulated amounts in pituitary adenomas. This study also demonstrated that in non-neoplastic adenohypophyses, increase of clusterin positive cells; histopathological findings of calcification or presence colloidal material accumulation in large follicles were associated with age. To our knowledge, immunohistochemical localization of clusterin in pituitary adenomas was not reported previously.
Congenital anomalies of the ribs: An autopsy case report
(Comenius University, 2009) Durak, Dilek; Eren, Bülent; Fedakar, Recep; Türkmen, Nursel; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0002-8296-5484; 0000-0003-3469-340X; AAH-6287-2021; AAK-8096-2021; AAH-6587-2021; 56700124800; 8725969000; 8725968900; 8715251700
We describe a medico-legal autopsy case of a three-day newborn girl. This was the fifth pregnancy of the mother who was 34 years at that time. Her parents were non-consanguineous. There was no family history of congenital abnormalities. Her mother did not smoke or drink and did not recall toxic exposure during the pregnancy. The birth weight and physical examination was normal. The child died postnatal on the third day, with haemoptysis at home. To clarify the exact cause of death, the child was sent to the Council of Forensic Medicine. At the autopsy, in the internal observation, the bilateral first ribs were wide, the sternal extremity of the left second rib was bifid, the eighth ribs were bilaterally connected to the sternum via costal cartilages. Microscopic pathological findings were not found. Analyses of the deceased's blood and urine were negative for drugs. In this case, genetic study was not done. Based on all information available, the cause of death was not definitely determined.
Deaths in the Turkish hamam (hot bath)
(Comenius University, 2009) Akan, Okan; Eren, Bülent; Fedakar, Recep; Türkmen, Nursel; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0002-8296-5484; AAH-6287-2021; AAK-8096-2021; 8725969000; 8725968900; 8715251700
Hamam (Hot Bath) culture is prevalent worldwide. The high temperature and humidity of these places have multiple effects on human health. The aim of this study was to investigate the demographic characteristics, autopsy findings and causes of death of cases who died in hamam and underwent medicolegal autopsies. The study was performed on 15 cases who experienced sudden death or died suspiciously in hamam and autopsied between January 1999 and December 2004. Eleven cases were men and 4 were women. Mean age was 69.5 +/- 3.1 and median age was 74. Eight cases were found dead in a bathtub or pool whereas seven were found out of water. Six of the cases older than 65 died in winter months. The causes of death were recorded as acute cardiac failure in 13 cases, pneumonia and cardiac failure in one, pneumonia and acute pancreatitis in the last case. Elderly patients with cardiac failure and coronary heart disease experience significant health problems in saunas and hamams. They should avoid this tradition unless approved by their physicians.
A distant-range, suicidal shotgun wound of the back
(Wiley, 2006) Durak, Dilek; Fedakar, Recep; Türkmen, Nursel; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0003-3469-340X; AAH-6287-2021; AAH-6587-2021; 56700124800; 8725968900; 8715251700
The case being reported is one of a shotgun fatality with a thoracic back wound. A 23-year-old man was shot from a distance with trajectories going from back to front and on a nearly horizontal level. These findings observed in the autopsy could represent homicide, but scene investigation and police records were interpreted and it became clear that the case was suicide. Thus, this case shows that the determination of the manner of death requires a careful forensic investigation including autopsy findings, scene investigation, and reconstruction of the events.
Evaluation of age estimation in forensic medicine by examination of medial clavicular ossification from thin-slice computed tomography images
(Springer, 2016-06-17) Gürses, Murat Serdar; İnanır, Nursel Türkmen; Gökalp, Gökhan; Fedakar, Recep; Tobcu, Eren; Ocakoğlu, Gökhan; Tıp Fakültesi; Radyoloji Ana Bilim Dalı; AAH-5180-2021; AAI-2336-2021; AAH-6287-2021; 56712925300; 8312505100; 8725968900; 57190007205; 15832295800
Forensic age estimation, a recent topic of research in forensic medicine, is of primary importance to criminal and civil law. Previous studies indicate that the observation of medial clavicular ossification allows for age discrimination along the completed 18th and 21st years of life. Experts recommend that the Schmeling and Kellinghaus methods be used together. In this study, we used these staging methods to retrospectively analyze 725 case studies (385 males, 340 females) of thin-slice computed tomography (CT) images, ranging from 0.6 to 1 mm in thickness, from individuals aged 10 to 35 years. Stage 1 was found at 18 years of age maximum for males, whereas it was found at 17 years of age for females. Stage 2a was found at 18 years of age maximum for both genders. Stage 3c was initially observed at 18 years for both genders. Stage 4 was initially found at 21 years for males and 20 years for females. Stage 5 was initially observed at 25 years for both genders. Of note, stage 3c was found close to 19 years of age for both genders (18.92 years for male, 18.99 years for female), and it may be employed to differentiate along the age majority cutoff. The data obtained from our study were consistent with previous studies. We believe that such a comprehensive database will greatly contribute to future studies focusing on medial clavicular ossification based on thin-slice CT. Moreover, we also recommend that if medial clavicular ossification based on CT is to be examined for forensic age estimation, both methods should be employed together.
Evaluation of the medial clavicular epiphysis according to the Schmeling and Kellinghaus method in living individuals: A retrospective CT study
(Elsevier, 2016-12-29) Ramadan, Selma Uysal; Gürses, Murat Serdar; Hacıfazlıoğlu, Çiğdem; Hızlı, Samil; İnanır, Nursel Türkmen; Fedakar, Recep; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; AAH-6287-2021; 56712925300; 8725968900
The evaluation of the medial clavicular epiphysis via CT plays an important role in the determination of age, particularly the 19th and 22nd ages. Several authors have recommended the use of the Schmeling and Kellinghaus methods in conjunction in the evaluation of the medial clavicular epiphysis. The aim of this retrospective study was to evaluate thin section CT scan images of the medial clavicular epiphysis according to the Schmeling and Kellinghaus method, and to discuss the obtained data in the light of the literature. The thoracic CT scan images (0.6 mm section thickness) of 601 patients (202 female and 399 male) aged between 10 and 35 years obtained by 16-detector CT were evaluated by two examiners. The stage 2 was seen between 13 and 23 years of age; stage 3 was seen between 16 and 27 years of age. However, 100% of the female cases with stage 3c were >= 18 years of age, and 100% of the male cases with stage 3c were >= 19 years of age. Stage 4 was first observed at 20 years of age in both sexes, and stage 5 was first observed at 25 years of age in both sexes. We believe that stage 3c may be used, particularly in the determination 18-year age limit for both sexes. The outcomes of our study are consistent with those of our previous study and other studies in the literature, which is important for the confirmation of the reliability of the method.
Evaluation of the ossification of the medial clavicle according to the Kellinghaus substage system in identifying the 18-year-old age limit in the estimation of forensic age-is it necessary?
(Springer, 2016-12-02) Gürses, Murat Serdar; İnanır, Nursel Türkmen; Soylu, Esra; Gökalp, Gökhan; Kır, Elif; Fedakar, Recep; Tıp Fakültesi; Radyoloji Ana Bilim Dalı; AAI-2336-2021; AAH-6287-2021; 56712925300; 57200888554; 8312505100; 57192388153; 8725968900
The evaluation of the ossification of the medial clavicular epiphysis being part of an assigned expert approach according to standard plays an important role within civil and criminal proceedings in assessing whether a person has reached her/his 19th or 22nd year of age. Evaluation of the medial clavicular epiphysis with thin-section CT is one of the methods recommended by the Study Group on Forensic Age Diagnostics of the German Association of Forensic Medicine. In this retrospective study, we evaluated the thin-section CT (section thickness of 0.6 and 1 mm) images of 254 patients (146 male, 108 female) with an age range of 13-28 years according to the Kellinghaus substage system. The mean values of female patients were observed to be about 10 months lower for stage 2a than the mean values of the male patients, about 13 months lower for stage 2b, and about 18 months lower for stage 2c. The earliest appearance for stage 3c was at 19 years in both sexes. Our data from this study were consistent with both our previous studies and the data of other studies. We think that stage 3c is important in determining whether a person has reached the age of 18 or not and, therefore, that the Kellinghaus substage system is a requirement in the assessment of forensic age.
Expressions of endocan in patients with meningiomas and gliomas
(Hindawi, 2016-06-30) Atukeren, Pınar; Kunbaz, Ahmad; Türk, Okan; Kemerdere, Rahsan; Ulu, Mustafa Onur; Tanrıverdi, Taner; İnanır, Nursel Türkmen; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0002-4047-6455; 57188706721
Objective. Endocan has been shown to be a marker for several cancers and may show degree of malignancy. The aim of this study is to assess tissue levels of endocan in common brain tumors, namely, meningiomas, low-grade gliomas (LGGs), and high-grade gliomas (HGGs). Patients and Methods. Endocan was assayed by commercially available enzyme linked immunosorbent assay (ELISA) kits in a total of 50 brain tumors (20 meningiomas, 19 LGGs, and 20 HGGs) and 15 controls. The results were compared to control brain tissues. Results. Each tumor group showed significant higher levels of endocan compared to controls (p < 0.05). In addition, endocan levels showed steady increase from the least (meningiomas) to the most (HGGs) malignant tumors and positive correlation was noted between the degree of malignancy and endocan level (p = 0.0001). Conclusion. Endocan, a vital molecule for angiogenesis, is expressed in common brain tumors and results suggest that endocan could be a marker for malignancy.
Fatal blunt trauma of the larynx in a child
(Wiley, 2005-09) Saka, Naile Esra; Durak, Vahide Aslıhan; Durak, Dilek; Fedakar, Recep; Eren, Bülent; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0002-8296-5484; 0000-0003-3469-340X; AAK-8096-2021; AAH-6587-2021; AAH-6287-2021; 56700124800; 8725968900; 8725969000
We report an autopsy case of an 11-year-old girl who suffered mechanical asphyxia from falling off the metal bars in the playground. This autopsy case is interesting because of the atypical trauma and lesions. To our knowledge there has been no similiar published case reports in the forensic literature. The young age of the victim, the setting and the pattern of the injuries are rare in a fall at playground by a child.

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