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Permanent URI for this collectionhttps://hdl.handle.net/11452/20668

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Browsing by Department "Acil Tıp ve Travma Merkezi"

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    Effects of vitamin E and cimetidine on peritonitis-induced lipid peroxidation
    (Springer, 1997-11) Tuncel, Pınar; Gür, Esma Sürmen; Kaya, Ekrem; Özbek, Resul; Öztürk, Ercan; Tokyay, Rıfat; Tıp Fakültesi; Tıp Fakültesi; Tıp Fakültesi; Biyokimya Ana Bilim Dalı; Acil Tıp ve Travma Merkezi; Cerrahi Ana Bilim Dalı; 0000-0001-7377-9682; AAG-7327-2021; 7801598700; 7801407302; 7004568109; 6507218522; 36967322600; 7003296847
    To investigate the effects of acute fecal peritonitis on plasma and tissue lipid peroxidation and possible protective effects of vitamin E (Vit E) and cimetidine at 4 h in a rat peritonitis model, four groups were designated as: controls, peritonitis, Vit E and cimetidine. Plasma, liver, lung and kidney thiobarbituric acid reactive substances (TBARS) and conjugated diene (CD) levels were measured to monitor oxidative injury. The present fecal peritonitis model caused a significant elevation in liver TBARS; however, neither Vit E nor cimetidine was effective in preventing TBARS formation. Administration of Vit E and cimetidine caused significant decrements from the peritonitis value in liver and lung CD levels.