Browsing by Author "UNCU, GÜRKAN"

Now showing 1 - 20 of 36

A comparison of the survival and implantation rates of blastocysts that were vitrified on post-fertilization day five, six and seven
(Taylor & Francis Ltd, 2019-07-03) Barış, Ata; AVCI, BERRİN; KUŞPINAR, GÖKTAN; UNCU, GÜRKAN; Gürkan, Uncu; Berrin, Avcı; Işıl, Kasapoğlu; KASAPOĞLU, IŞIL; Göktan, Kuşpınar; Seda, Sarıbal; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Jinekoloji ve Doğum Anabilim Dalı.; ABE-6685-2020
The goal of this retrospective cohort study was to compare survival, implantation, clinical and ongoing pregnancy rates between blastocysts that were vitrified on post-fertilization days 5, 6 and 7. Before vitrification, blastocysts were evaluated in terms of morphology and blastocyst expansion, inner cell mass and trophectoderm quality. They were thawed and transfered in a subsequent artificial cycle. Embryo implantation rates were 39%, 25% and 25% for blastocysts that were vitrified on days 5, 6, and 7, respectively (p = 0.006). Clinical and ongoing pregnancy rates were 19%, 12%, 13% (p = 0.100) and 9%, 7%, 12% (p = 0.99) for days 5, 6 and 7 blastocysts, respectively. Day 5 blastocysts had significantly higher full-collapsing score after assisted-hatching compared to days 6 and 7 blastocysts (p = 0.014). As blastocyst quality increased, implantation and clinical pregnancy rates increased in all groups and both parameters were statistically significantly higher on day 5 blastocysts than on days 6 or 7 (p = 0.001). It was clearly found that good quality blastocysts obtained on day 5 have higher implantation and clinical pregnancy rates than 6th and 7th day cryopreserved embryos. There were no statistically significant differences between the cryopreserved embryos on days 6 and 7 regarding the implantation, clinic and ongoing pregnancy rates.
A huge vaginal stone in a spastic paraplegic woman
(Springer London Ltd, 2022-05-11) Aslan, Kiper; ASLAN, MÜNİR KİPER; Akkok, Tuğba; AKKÖK, TUĞBA; Kasapoglu, Işıl; KASAPOĞLU, IŞIL; Uncu, Gürkan; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0002-9277-7735; AER-7173-2022
A meshless practical laparoscopic sacrohysteropexy modification and long-term outcomes
(Elsevier, 2020-11-01) Orhan, Adnan; Özerkan, Kemal; Kasapoglu,Işıl; Ocakoğlu, Gökhan; Aslan, Kiper; Uncu, Gürkan; ORHAN, ADNAN; ÖZERKAN, KEMAL; KASAPOĞLU, IŞIL; OCAKOĞLU, GÖKHAN; ASLAN, MÜNİR KİPER; UNCU, GÜRKAN; Uludağ Üniversitesi/ Tıp Fakültesi/Doğum ve Jinekoloji Bölümü/Ürojinekol ve Minimal İnvas Jinekol Ünitesi; Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Biyoistatistik Anabilim Dalı; 0000-0002-7558-8166; 0000-0002-1114-6051; 0000-0002-9277-7735; V-5292-2019; AER-7173-2022; AAH-9694-2021; AAT-3479-2021; AAH-9791-2021; AAH-5180-2021; K-2269-2016
Study Objective: To describe a new modification of laparoscopic sacrohysteropexy without using a mesh and report the 3-year outcomes.Design: A prospective cohort study.Setting: Minimally Invasive Gynecology Unit, Bursa Uludag University Hospital, Turkey.Patients: Women who were diagnosed with >= stage 2 uterine prolapse.Interventions: A laparoscopic sacrohysteropexy modification using a polyester fiber suture instead of a standard polypropylene mesh.Measurements and Main Results: The primary outcome was the anatomic success of the repair, with success defined as objective parameters using the pelvic organ prolapse quantification system. The secondary outcomes were subjective outcomes, which were assessed using the quality-of-life scales. Forty-seven women who underwent the procedure were followed up for a minimum of 3 years. Forty-four of the 47 patients had stage 0 or 1 prolapse at the end of the second year, according to the primary outcomes. The anatomic success rate was 93.6%. In the secondary outcomes, 2 patients were not satisfied with their pelvic floor after the second year. The subjective cure rate was 95.7%. There was a statistically significant improvement in both pelvic organ prolapse quantification and quality-of-life scores in the third postoperative year. The mean operating time was 84.6 minutes, and the mean estimated blood loss was 21.3 mL. There were no bladder or bowel complications in the perioperative or postoperative period.Conclusion: Laparoscopic sacrohysteropexy can be performed safely with this meshless modification in uterine prolapse as an alternative. (c) 2020 AAGL. All rights reserved.
Amh levels may predict for mullerian anomalies and pregnancy outcomes patients with pcos.
(Elsevier, 2020-09-01) Aslan, Kiper; ASLAN, MÜNİR KİPER; Albayrak, Özge; Bilgiç, Kübra Özlem; BİLGİÇ, KÜBRA ÖZLEM; Kasapoglu, Işıl; KASAPOĞLU, IŞIL; Avci, Berrin; AVCI, BERRİN; Uncu, Gurkan; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0002-9277-7735; AAH-9694-2021; AER-7173-2022; AAT-3479-2021
An endometriosis patient presented with gross hematuria as a complication of the oocyte pick-up procedure
(Sage Publications Ltd, 2016-10-01) KASAPOĞLU, IŞIL; Kasapoğlu, Işıl; Aslan, Elif Külahçı; ASLAN, ELİF; Uncu, Gürkan; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0002-6553-1350; AAT-3479-2021
Purpose: To report a case of a 34-year-old female with endometriosis and a complication presented with gross hematuria due to bladder injury after transvaginal oocyte retrieval for in vitro fertilization.Case Report: A 34-year-old woman with endometriosis presented with gross hematuria 4 days after oocyte - retrieval and was conservatively followed up.Results: As an uncommon emerging situation after oocyte retrieval for in vitro fertilization procedure, gross hematuria is pointed as a complication with an endometriosis patient.Conclusions: Although a transvaginal approach is accepted as a safe and simpler technique for oocyte retrieval, complications like adjacent organ injury should be kept in mind. Especially in patients with endometriosis, in whom pelvic anatomy is distorted due to adhesions, oocyte pick-up procedure should be carried out more carefully.
Are all antral follicles the same? Size of antral follicles as a key predictor for response to controlled ovarian stimulation
(Taylor & Francis, 2021-06-21) Kasapoğlu, Işıl; Orhan, Adnan; Aslan, Kiper; Şen, Esra; Kaya, Ayşenur; Avcı, Berrin; Uncu, Gürkan; KASAPOĞLU, IŞIL; ORHAN, ADNAN; ASLAN, MÜNİR KİPER; KAYA, AYŞENUR; AVCI, BERRİN; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.; 0000-0002-7558-8166; 0000-0002-9277-7735; AAH-9694-2021; AER-7173-2022; CXJ-7203-2022; V-5292-2019; JWJ-7388-2024; ELU-2357-2022; AAT-3479-2021
The aim of this study was to evaluate whether antral follicle size has any value with respect to antral follicle count (AFC) in predicting ovarian response to controlled ovarian stimulation. Patients who were considered to be normal responders based on their ovarian reserve markers were consecutively recruited. Total AFC was the number of 2-10 mm follicles in both ovaries. Antral follicles were separated into two subgroups according to the size: 2-5 mm and 6-10 mm follicles. Patients were divided into two main groups according to ovarian response to COS. Group 1 (suboptimal response, 4-9 oocytes retrieved, n = 61) and Group 2 (normal responders, >= 10 oocytes retrieved, n = 65). Demographic parameters were comparable between the groups. The number of 2-5 mm follicles was significantly lower in the suboptimal response group (5 [4:7] and 8 [6:10], respectively, p < .001). The ratio of 2-5 mm follicles to total antral follicles was also significantly lower in Group 1 (44.4% and 75%, respectively, p < .001). The ratio of small antral follicles was positively correlated with ovarian response (r = 0.587, p < .001). In conclusion, the ratio of small (2-5 mm) antral follicles could be a more specific predictive marker than AFC for ovarian response.IMPACT STATEMENT What is already known on this subject? Prediction of the ovarian response during ovarian stimulation is commonly based on antral follicle count and anti-mullerian hormone. The ovarian response may be inadequate even in patients with normal antral follicle count and anti-mullerian hormone. What do the results of this study add? A high ratio of small-size (2-5 mm) basal antral follicles is a predictive factor for higher ovarian response to ovarian hyperstimulation. What are the implications of these findings for clinical practice and/or further research? To obtain optimal ovarian response, the antral follicles should be evaluated initially in a more detailed and systematic way by taking their sizes into consideration in addition to their counts. Small antral follicle count rather than whole antral follicle count may be beneficial for optimising the ovarian response. Future studies may determine the cut off values of small antral follicle count for high/poor ovarian response.
Comparison of ICSI outcomes with hypo-osmotic swelling (HOS) reactive sperm and motile sperm on sibling oocytes in patients with severe asthenospermia
(Oxford Univ Press, 2018-07-01) Çakır, C.; Kasapoğlu, Işıl; Sarıbal, Seda; Uncu, Gürkan; Avcı, Berrin; ÇAKIR, CİHAN; KASAPOĞLU, IŞIL; Sarıbal, Seda; UNCU, GÜRKAN; AVCI, BERRİN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Üreme Biyolojisi; ABE-6685-2020; AAT-3479-2021; JMI-6129-2023; CXJ-7203-2022; FTW-2214-2022
Comparison of semen parameters in the same patients before and after diagnosis of COVID-19
(Wiley, 2023-09-01) Çakır, Cihan; Kuşpınar, Göktan; Kurt, Gizem; Berber, Miray; Aslan, Kiper; Kasapoğlu, Işıl; Uncu, Gürkan; Avcı, Berrin; ÇAKIR, CİHAN; KUŞPINAR, GÖKTAN; Kurt, Gizem; Berber, Miray; ASLAN, MÜNİR KİPER; KASAPOĞLU, IŞIL; UNCU, GÜRKAN; AVCI, BERRİN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0002-8332-7353; 0000-0002-9277-7735; AAH-5249-2021; HTQ-5866-2023; DBD-8926-2022; JLV-2420-2023; AER-7173-2022; CXJ-7203-2022; AAT-3479-2021; ELU-2357-2022
Clinical and histopathological evidence suggest that the male reproductive system may be negatively impacted in patients with coronavirus disease (COVID-19). The objective of this study is to investigate the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on semen parameters by comparing semen analyses before and after COVID-19 diagnosis in the same patient. We retrospectively analyzed 342 semen analyses by reviewing medical records. The study included two groups of patients: (i) those who underwent two consecutive semen analyses within 6 months, one before (n = 114) and one after (n = 114) COVID-19 diagnosis, and (ii) a control group (n = 114) that was age-matched and did not receive a diagnosis of COVID-19. The study results indicated a significant decrease in semen volume, total sperm count per ejaculate, progressive motile sperm count, total motile sperm count, and normal sperm morphology after SARS-CoV-2 infection in comparison to their respective values before the infection. Subgroup analyses showed that the duration of COVID-19 diagnosis (short-term vs. long-term) did not impact the changes in semen parameters. However, fever during the COVID-19 process had a negative effect on semen parameters, particularly sperm concentration, unlike in patients without fever. In conclusion, our findings suggest that SARS-CoV-2 infection is associated with a decline in semen quality, which may potentially impact male fertility. Furthermore, it's important to note that the negative effects on semen parameters may persist in the long-term. Our results also indicate that fever during active infection could be a significant risk factor that negatively affects spermatogenesis.
Comparison of survival and implantation rates of blastocysts that were vitrified on post-fertilization day 5, 6 OR 7
(Elsevier, 2015-09-01) Sarıbal, Seda; Uncu, Gürkan; Ata, Barış; Avcı, Berrin; Sarıbal, Seda; UNCU, GÜRKAN; AVCI, BERRİN; Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Bölümü; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum; ABE-6685-2020; AAT-3479-2021; FTW-2214-2022
Does adjuvant usage in the luteal phase improve live birth rates of icsi - et patients with previous implantation failure?
(Oxford Univ Press, 2022-07-01) UNCU, GÜRKAN; Uncu, Gürkan; Kasapoğlu, I.; KASAPOĞLU, IŞIL; ASLAN, MÜNİR KİPER; Çınar, C.; Kuşpınar, G.; KUŞPINAR, GÖKTAN; Avcı, B.; AVCI, BERRİN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0002-9277-7735; HTQ-5866-2023; AER-7173-2022
Does endometriosis have more detrimental effect on ovarian reserve in the presence of autoimmunity? A prospective observational study
(Oxford Univ Press, 2023-06-01) UNCU, GÜRKAN; Uncu, Gürkan; Aslan, Kiper; Nerimanova, C.; Kasapoglu, Işıl; KASAPOĞLU, IŞIL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
Does gonadotropin dose adjustment in inadequate ovarian response during controlled ovarian hyperstimulation improve the live birth rates of patients with diminished ovarian reserve?
(Oxford Univ Press, 2022-07-01) Mesut, O. C.; MESUT, ÖMER ÇAĞATAY; Gürbüz, T. B.; GÜRBÜZ, TANSU BAHAR; Aslan, K.; ASLAN, MÜNİR KİPER; Uncu, G.; UNCU, GÜRKAN; Kasapoğlu,; KASAPOĞLU, IŞIL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
Does the presence of endometriosis cause a challenge for transvaginal oocyte retrieval? A comparison between patients with and without endometriosis
(Galenos Yayıncılık, 2018-03-12) Kasapoğlu, Işıl; Türk, Pınar; Dayan, Aylin; Uncu, Gürkan; KASAPOĞLU, IŞIL; Türk, Pınar; Dayan, Aylin; UNCU, GÜRKAN; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; AAT-3479-2021; CXJ-7203-2022; JJP-1980-2023; ETO-8465-2022
Objective: The aim of the study was to compare patients with and without endometriosis regarding performance rates, difficulties, and complications associated with transvaginal oocyte retrieval (TVOR) procedures.Material and Methods: A prospective cohort study was conducted at the In Vitro Fertilization Unit of the Division of Reproductive Endocrinology and Infertility Department of a university hospital. Fifty-eight patients with endometriosis and 61 patients without endometriosis underwent TVOR procedures consecutively. Primary outcome measures were; number of needle entries per patient and performance rating defined as the total number of oocytes retrieved per vaginal needle entry. The requirement for manual compression of the abdominal wall (assistance) to reach the ovaries, procedure-related pain, and procedural complications were also evaluated.Results: The median number of needle entries through the vaginal wall per patient was comparable between the two groups (p=0.45). Performance rates were higher in the control group (p=0.001). Performance rates and total number of the needle entries through the vaginal wall were not significantly correlated with ovarian endometrioma (OMA) diameter (r=0.28; p=0.68; r=0.275, p=0.068, respectively) in the endometriosis group. Body mass index (BMI) scores were found to be correlated with the number of the needle entries and higher BMI scores were associated with higher numbers of vaginal wall punctures (p< 0.001). The requirement for manual compression of the abdominal wall was significantly higher in the control group (57.4% vs 27.6%, p=0.001). A similar proportion of women needed analgesic medications after the TVOR procedure in both groups (10.3% vs 16.9%, p=0.33). Hospital readmissions for any symptoms were also comparable between the two groups (p=0.22). Three women were treated for pelvic infection, all of whom were in the endometriosis group.Conclusion: Endometriosis seems to cause a challenge for TVOR that may have reflection on individual surgeon's performance rates for the procedure, independently from the diameter of a pre-existing OMA or ovarian adhesions. Obesity is another factor that may present a challenge for the procedure.
Does the recurrence of ovarian endometrioma affect the pregnancy rates in IVF?
(Elsevier, 2015-09-01) Aslan, Kiper; Kasapoğlu, Işıl; Avcı, Berrin; Ata, Barış; Uncu, Gürkan; ASLAN, MÜNİR KİPER; KASAPOĞLU, IŞIL; AVCI, BERRİN; Ata, Barış; UNCU, GÜRKAN; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları; Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Bölümü; Uludağ Üniversitesi/Tıp Fakültesi/Endokrinolojisi Bölümü; 0000-0002-9277-7735; 0000-0003-1106-3747; ABE-6685-2020; AAH-9694-2021; AER-7173-2022; C-8049-2013; AAT-3479-2021; CXJ-7203-2022
Effect of embryo morphology on maternal serum β-hCG level in pregnancies resulting from a fresh single cleavage embryo and a fresh single blastocyst
(Oxford Univ Press, 2018-07-01) Kuşpınar, Göktan; Kasapoğlu, Işıl; Sarıbal, Seda; Uncu, Gürkan; Avcı, Berrin; KUŞPINAR, GÖKTAN; KASAPOĞLU, IŞIL; Sarıbal, Seda; UNCU, GÜRKAN; AVCI, BERRİN; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Kadın Hastalıkları ve Doğum Anabilim Dalı; 0000-0002-0338-8368; AAH-5119-2021; HTQ-5866-2023; AAT-3479-2021; ABE-6685-2020; CXJ-7203-2022; FTW-2214-2022
Evaluation of endometrioma pathophysiology and related ovarian damage by PTEN / AKT apoptosis signaling pathway
(Elsevier Science, 2020-09-01) Şen, Furkan; Aslan, Kiper; Kuşpınar, Göktan; Çakır, Cihan; Kasapoglu, Işıl; Avcı, Berrin; Uncu, Gürkan; ŞEN, HAMZA FURKAN; ASLAN, MÜNİR KİPER; KUŞPINAR, GÖKTAN; ÇAKIR, CİHAN; KASAPOĞLU, IŞIL; AVCI, BERRİN; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-9277-7735; 0000-0002-8332-7353; AAH-5119-2021; AAT-3479-2021; HTQ-5866-2023; AER-7173-2022; AAH-9694-2021; AAH-5249-2021; KEU-2073-2024; CXJ-7203-2022; ELU-2357-2022
Fertilisation and early embryonic development of immature and rescue in vitro-matured sibling oocytes
(Taylor & Francis, 2020-01-16) Avcı, Berrin; Kasapoğlu, Işıl; Çakir, Cihan; Özbay, Aysun; Ata, Barış; Uncu, Gürkan; AVCI, BERRİN; KASAPOĞLU, IŞIL; ÇAKIR, CİHAN; Özbay, Aysun; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0002-8332-7353; 0000-0001-8135-5468; AAT-3479-2021; GQR-0770-2022; AAH-5249-2021; CXJ-7203-2022 ; ABE-6685-2020
The objective of this study was to assess the effect of rescue in vitro maturation and immediate intracytoplasmic sperm injection (ICSI) application on fertilisation success and early embryonic development of metaphase I (MI) oocytes. This was a retrospective cohort study including 2425 sibling oocytes in 259 ICSI cycles. ICSI was performed on 104 GV (germinal vesicle) oocytes which had reached the metaphase II (MII) stage (Group 1) and 231 MI oocytes which had reached the MII stage (Group 2) following IVM (in vitro maturation). Immediate ICSI was applied following oocyte aspiration on 292 MI stage (Group 3) and 1798 MII stage oocytes (Group 4). Normal fertilisation rates in Groups 1, 2, 3 and 4 were 51.9%, 39%, 30.1% and 59.5%, respectively. The rates of blastocyst development per oocyte and per zygote were calculated as 3.8%, 3.0%, 6.8%, 14.1% and 7.4%, 7.7%, 22.7%, 23.6% for Groups 1, 2, 3 and 4, respectively. The blastocyst development rate was significantly higher in the MI-ICSI group compared with other immature oocytes. Even though performing ICSI on the oocytes at the MI stage on the day of oocyte aspiration resulted in lower fertilisation rates, it was associated with significantly higher rates of blastocyst development.
Hysteroscopy results in patients with preoperative diagnosis of endometrial polyp
(Galenos Yayincilik, 2006-09-01) Özyürek, Eser S.; Tanrıkulu, İsmail; Kaya, Tülay; Uncu, Gürkan; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; AAT-3479-2021
Objective: The retrospective evaluation of hysteroscopy results in cases primarily diagnosed as endometrial polyps.Design: Retrospective analysis of clinical dataSetting: University hospital clinic.Patients and Method: 79 patients who have applied to the Uludag University Obgyn Department Ambulatory-clinic, have been diagnosed as endometrial polyps and hysteroscopically operated were retrospectively analysed. Diagnosis was performed with transvaginal-ultrasonography (TVUSG) and/or saline-infusion-sonography (SIS). Space occupying lesions were hysteroscopicallyresected and sent for pathological examination. If no lesions were observed, endometrial sampling was performed and operation terminated. Hysteroscopic findings, histopathological results, diagnostic methods used, and symptoms the patients were presented with were analysed. Statistical analysis was performed with the SPSS 13.0 package and Microsoft Excel 2003.Main Outcome measures: Comparison of presumptive diagnosis with hysteroscopic and histopathological findings.Results: Specimen results were: endometrial polyps: 56(70,9%); submucous myoma: 8(10,1%); endometrial hyperplasia: 1(1,3%); asynchronic endometrium: 14(17,7%). The false positive rate of the primary diagnosis was 5(6,4%) and of hysteroscopic examination was 10(13,5%). Positive predictive values were: 79,5% for TVUSG; 83,3% for TVUSG+ SIS; and 86,4% for hysteroscopy.Conclusion: Symptoms caesed by endometrial polyps are various. Supplementing TVUSG with SIS increases diagnostic accuracy, almost as well as direct visualizing. Neither the size, location or the type of symptoms can discriminate polyps from other space occupying lesions of the endometrial cavity.
Incidence of congenital uterine abnormalities in polycystic ovarian syndrome (CONUTA Study)
(Elsevier, 2022-02-23) Aslan, Kiper; Albayrak, Özge; Orhaner, Aylin; Kasapoğlu, Işıl; Uncu, Gürkan; ASLAN, MÜNİR KİPER; Albayrak, Özge; Orhaner, Aylin; KASAPOĞLU, IŞIL; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0002-9277-7735; AER-7173-2022; AAT-3479-2021; GLW-1161-2022; GML-8923-2022; CXJ-7203-2022
Objective: To investigate whether the frequency of uterine cavity abnormalities in PCOS patients higher than the normo-ovulatory patients.Study design: This retrospective cohort study was conducted at the ART center of a tertiary university hospital. A total of 103 patients; 51 PCOS, and 52 male factor infertility were enrolled in the study between the years 2011-2019. HSG images of all patients were numbered and evaluated by ten senior reproductive endocrinologists and surgeons whom were blinded to the research and choose the most appropriate figure for each patient's HSG image and marked the shape of cavity according to the ASRM and ESGE/ESHRE classification.Results and demographic parameters were compared between PCOS and male factor infertility groups. Results: The percentage of the normal uterine cavity was significantly lower in the PCOS group than control group as 51 % and 66.7 %, 77 % and 94.2 % according to the ASRM and ESHRE/ESGE classifications, respectively. The frequency of Partial Septate Uterus (ESHRE-ESGE U2a / ASRM Va, 21.6% vs 5.8 % p < 0.05), Complete Septate Uterus (ESHRE-ESGE U2b / ASRM Vb, 7.8% vs 0% p < 0.01) and Dysmorphic Uterus (ESHRE-ESGE U1c) / ASRM VII) 3.9 % vs 0p < 0.05) were significantly higher in PCOS patients than controls. The frequency of arcuate uterus classified as VI in ASRM and considered as normal in ESHRE/ESGE was 16 % and 17.3 % in PCOS and control groups, respectively, without statistically significant difference.Conclusions: This study provides that, compared to the healthy population, the frequency of uterine cavity abnormality is clearly higher in PCOS patients.
Is fibroid location associated with hemorrhage and complication rates following laparoscopic myomectomy?
(Springer, 2020-05-26) Aslan, Kiper; Orhan, Adnan; Türkgeldi, Engin; Süer, Ebru; Düzok, Nergis; Özerkan, Kemal; Ata, Barış; Uncu, Gürkan; ASLAN, MÜNİR KİPER; ORHAN, ADNAN; SÜER, EBRU; DÜZOK, NERGİS; ÖZERKAN, KEMAL; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0002-9277-7735; 0000-0002-7558-8166; 0000-0002-5008-3292; K-2269-2016; AAH-9716-2021; AAT-3479-2021; AAH-9791-2021; AER-7173-2022; AAU-2710-2020; AAH-9694-2021; V-5292-2019
Objective To determine whether hemorrhage and complication rates vary according to the location of the dominant fibroid following laparoscopic myomectomy. Background Laparoscopic myomectomy is associated with less postoperative pain, analgesic requirement, shorter hospitalization period, and less febrile complications when compared to conventional laparotomy. Despite the advantages, complications like hemorrhage, blood transfusion, bowel and urinary tract injury, and conversion to laparotomy may be seen in laparoscopic myomectomy. We do not know whether the fibroid location affects these complications. Materials and methods Women, who underwent laparoscopic myomectomy at two different tertiary academic hospitals, were analyzed retrospectively. Only women with at least one intramural fibroid (Monroe type 3, 4, or 5) were included. Patients were categorized according to localization of the dominant fibroid, i.e., anterior uterine wall, posterior uterine wall, and fundus. Change in hemoglobin levels before and after surgery and complication rates were compared across categories. Results Two hundred nineteen women with a mean age of 35.7 +/- 6 years were included. There were 81 women with fundal fibroid, 56 with anterior wall, and 72 with posterior wall fibroid. The other ten women with intraligamentary and isthmic fibroid were excluded. The mean fibroid diameter was 6.7 +/- 2.6, 6.6 +/- 2.3, and 6.7 +/- 2.3 cm in the fundal, anterior, and posterior groups, respectively (p = 0.9). The median (25th-75th percentile) changes in hemoglobin levels were 1.5 (0.8-2.2), 1.3 (0.6-2.1), and 1.3 (0.9-2) g/dl in fundal, anterior, and posterior wall groups, respectively (p = 0.55). There were 5 (6.2%), 5 (8.9%), and 2 (2.8%) complications in fundal, anterior, and posterior wall groups, respectively (p = 0.33). Conclusion The incidence of hemorrhage or complication does not seem to vary depending on the fibroid location. However, the sample size was limited; observed values suggest that fibroid location does not affect hemorrhage and complication rates.