Browsing by Author "Pehlivan, Yavuz"
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Publication A successful pregnancy in a patient with takayasu's arteritis under tocilizumab treatment: A longitudinal case study(Wiley, 2019-10-01) Dalkılıç, Ediz; Coşkun, Belkıs Nihan; Yağız, Burcu; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı; 0000-0001-8645-2670; 0000-0003-0298-4157; 0000-0002-0624-1986; 0000-0002-7054-5351; JQW-5031-2023; AAG-7155-2021; AAG-8227-2021; CMF-4757-2022Item Are biologic agents effective on the treatment of secondary amyloidosis: A multicenter report on turkish rheumatoid arthritis and ankylosing spondylitis patients(Wiley, 2014-10) Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; AAG-8227-2021; 13205593600Publication Attitudes of patients with a rheumatic disease on drug use in the COVID-19 pandemic(BMC, 2021-09-03) Coşkun, Belkıs Nihan; Pehlivan, Yavuz; Dalkılıç, Ediz; COŞKUN, BELKIS NİHAN; PEHLİVAN, YAVUZ; DALKILIÇ, HÜSEYİN EDİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı; 0000-0003-0298-4157; AAG-8227-2021; CMF-4757-2022Background Anti-rheumatic drugs can increase the predisposition to infection, and patients may be unaware of continuing their treatment during the COVID-19 pandemic. Objective This study aimed to assess whether patients maintain their treatment for rheumatic conditions during the pandemic period and determine the factors responsible for discontinuation. Methods Patients were randomly selected from the prospectively collected database of our tertiary referral center. The patients were interviewed by telephone through a standardized closed-ended questionnaire, which is targeting the continuity of the treatment plan and the considerations related to the individual choice. The patients were asked whether they hesitated to visit the hospital for follow-up or intravenous drug administration. Results A total of 278 patients completed the questionnaire. While 62 of the patients (22.3%) had reduced or interrupted the treatment, only 11 patients (3.9%) stopped the treatment completely. A significant difference was observed between the duration of illness and the discontinuation of treatment. (p = 0.023) There was a significant difference in disease activity between the group that stopped treatment and continued treatment. (p = 0.001) There was no statistically significant difference in other demographic characteristics. One hundred thirty-five patients (48.6%) made the treatment decision by themselves, and 80% continued the treatment. Reasons for stopping the treatment were anxiety (48.4%), not being able to go to the hospital for intravenous treatment (45.1%), and not being able to find the drug (6.5%). Conclusion Since patients with long-term illnesses were found to be significantly more likely to stop their treatment, this group of patients should be monitored.Item Behçet disease with vascular involvement: Effects of different therapeutic regimens on the incidence of new relapses(Lippincott Williams & Wilkins, 2015-02) Öner, Fatma Alibaz; Karadeniz, Aslı; Yılmaz, Sema; Balkarlı, Ayşe; Kimyon, Gezmiş; Yazıcı, Ayten; Çınar, Muhammet; Yılmaz, Sedat; Yıldız, Fatih; Bilge, Şule Yaşar; Bilgin, Emre; Omma, Ahmet; Çetin, Gözde Yıldırım; Çağatay, Yonca; Karaaslan, Yaşar; Sayarlıoğlu, Mehmet; Kalyoncu, Umut; Karadağ, Ömer; Kaşifoğlu, Timuçin; Erken, Eren; Pay, Salih; Çefle, Ayşe; Kısacık, Bünyamin; Onat, Ahmet Mesut; Çobankara, Veli; Direskeneli, Haner; Coşkun, Belkıs Nihan; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; 0000-0003-0298-4157; AAG-7155-2021; AAG-8227-2021; 55646165400; 13205593600Vascular involvement is one of the major causes of mortality and morbidity in Behcet disease (BD). There are no controlled studies for the management of vascular BD (VBD), and according to the EULAR recommendations, only immunosuppressive (IS) agents are recommended. In this study, we aimed to investigate the therapeutic approaches chosen by Turkish physicians during the initial event and relapses of VBD and the association of different treatment options with the relapses retrospectively. Patients with BD (n = 936, female/male: 347/589, mean age: 37.6 +/- 10.8) classified according to ISG criteria from 15 rheumatology centers in Turkey were included. The demographic data, clinical characteristics of the first vascular event and relapses, treatment protocols, and data about complications were acquired. VBD was observed in 27.7% (n = 260) of the patients during follow-up. In 57.3% of the VBD patients, vascular involvement was the presenting sign of the disease. After the first vascular event, ISs were given to 88.8% and AC treatment to 59.8% of the patients. Median duration of AC treatment was 13 months (1-204) and ISs, 22 months (1-204). Minor hemorrhage related to AC treatment was observed in 7 (4.7%) patients. Asecond vascular event developed in 32.9% (n = 86) of the patients. The vascular relapse rate was similar between patients taking only ISs and AC plus IS treatments after the first vascular event (29.1% vs 22.4%, P = 0.28) and was significantly higher in group taking only ACs than taking only ISs (91.6% vs 29.1%, P < 0.001). During follow-up, a third vascular event developed in 17 (n = 6.5%) patients. The relapse rate was also similar between the patients taking only ISs and AC plus IS treatments after second vascular event (25.3% vs 20.8%, P = 0.93). When multivariate analysis was performed, development of vascular relapse negatively correlated with only IS treatments. We did not find any additional positive effect of AC treatment used in combination with ISs in the course of vascular involvement in patients with BD. Severe complications related to AC treatment were also not detected. Our results suggest that short duration of IS treatments and compliance issues of treatment are the major problems in VBD associated with vascular relapses during follow-up.Item Behçet hastalarında demografik, klinik ve paraklinik özelliklerin retrospektif değerlendirilmesi(Bursa Uludağ Üniversitesi, 2019) Özdemir, Zeliha Kübra; Pehlivan, Yavuz; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.Behçet Hastalığı (BH), tekrarlayan oral ve genital aft, oküler hastalık, cilt lezyonları başta olmak üzere gastrointestinal, nörolojik, vasküler veya eklem gibi çeşitli sistemik tutulumlarla karakterize kronik inflamatuar bir hastalıktır. Etiyolojisi günümüzde hala bilinmemekle birlikte enfeksiyöz, genetik ve immünolojik faktörler üzerinde durulmaktadır. Başlangıç yaşı ülkeler arasında değişkenlik göstermekle birlikte sıklıkla 20-40 yaşlar arasındadır. Hastalığın prevelansı, cinsiyet dağılımı ve tutulum şekli coğrafik farklılık gösterir. Hastalık genellikle erkeklerde daha şiddetlidir. Alevlenme ve iyileşme dönemleri ile seyreder. Yaş ilerledikçe klinik belirtiler gerileme eğilimindedir. Bu çalışmanın amacı Türkiye’de sık görülen ve her hekimin bilgi sahibi olması gereken BH ile takipli hastalarımızın demografik, klinik ve paraklinik özelliklerini gözden geçirmek ve farkındalığı artırmaktır. Çalışmada Uludağ Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı ile Romatoloji Bilim Dalı polikliniklerinde BH tanısı alan, 2010-2018 yılları arasında takip ve tedavisi devam eden 488 hastanın demografik özellikleri, klinik ve paraklinik verileri, tanı anı bulguları ve kullandığı ilaçlar retrospektif olarak incelendi. BH ile takip ettiğimiz 488 hastanın 299’u (%61,3) erkekti. Bireylerin yaşları 19-78 arasında değişmekte olup; yaş ortalaması 40,7±9,9 iken, hastalık başlangıç yaş ortalaması 30,8±8,8 idi. Hastaların %96,9’unda (n=473) oral aft ve %58,8’inde ise (n=287) genital ülser saptandı. Cilt tutulumu olan 332 hastanın 169’unda (%50,9) sadece psödofolikülit bulunurken, venöz tutulum olan 108 hastanın 62’sinde (%57,4) derin ven trombozu mevcuttu. Tanı anındaki en sık bulgular sırasıyla oral aft (%30,1), genital ülser (%27,5) ve oküler tutulum (%12,5) şeklindeydi. Hastaların 63’ünde biyolojik tedaviye geçildiği ve 25’inin ilaçsız takip edildiği saptandı. 40 yaş altı, erkek ve oküler tutulumu olan hastalarda tedavide biyolojik ajan kullanım sıklığının daha fazla olduğu görüldü. BH, ülkemizde sık görülen, multisistemik tutulumla karakterize, farklı semptom ve bulgularla prezente olabilen sistemik bir vaskülittir. Morbidite ve mortaliteyle sonuçlanabildiği gibi günümüzde tedavisinde başarıyla kullanılan biyolojik ajanlar, hastalık prognozunu olumlu yönde etkilemektedir. Hastalık başlangıç yaşı, cinsiyet dağılımı ve prognoz coğrafik ve etnik farklılık gösterdiğinden popülasyon temelli çalışmalar önem taşır. Erkek cinsiyet ve erken hastalık başlangıcı şiddetli hastalıkla ilişkili olup biyolojik ajan kullanımının bu grupta fazla oluşu bunu desteklemektedir. Bu çalışma ile Türkiye’de sık görülen BH ile ilgili verilerimizi derlemeyi, tedavi seçeneklerini ve etkileyen faktörleri değerlendirerek klinik pratiğimize ışık tutmayı amaçladık.Item Behçet hastalarının uyku kalitesi, depresyon düzeyi ve etkileyen faktörler(Bursa Uludağ Üniversitesi, 2020-06-10) Araz, Can; Güner, Altuğ; Pehlivan, Seda; Pehlivan, Yavuz; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bilim Dalı.; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Fakültesi/Hemşirelik Bölümü/İç Hastalıkları Hemşireliği Anabilim Dalı.; 0000-0001-7220-0288; 0000-0002-1670-0672; 0000-0002-7054-5351Çalışma, Behçet hastalarının uyku kalitesi, depresyon düzeyleri ve etkileyen faktörleri belirlemek amacıyla tanımlayıcı olarak yapıldı. Çalışmaya katılmayı kabul eden 44 Behçet hastası çalışmaya dahil edildi. Çalışmanın verileri, araştırmacılar tarafından hazırlanan “Hasta Bilgi Formu”, “Pitsburg Uyku Kalitesi İndeksi (PUKİ)”, “Beck Depresyon Ölçeği (BDÖ)”, Behçet Hastalığı Yaşam Kalitesi Ölçeği (BHYKÖ)” ve “Behçet Hastalığı Güncel Aktivite Formu” ile toplandı. Verilerin değerlendirilmesinde, Mann Whitney U ve Spearman korelasyon analizleri yapıldı. Hastaların yaş ortalamasının 37,38±8,33 yıl, %90,9'unun erkek ve hastalık süresi ortalamasının 7,54±4,72 yıl olduğu belirlendi. Genital ülseri olan hastaların PUKİ puanının anlamlı olarak yüksek olduğu saptandı (p<0,05). Diğer tanımlayıcı özellikler açısından PUKİ, BDÖ, BHYKÖ puanları arasında anlamlı bir fark bulunmadı (p>0,05). Hastalık aktivite skoru ile PUKİ, BDÖ, BHYKÖ puanları arasında anlamlı ilişki olduğu belirlendi (p<0,05). Ayrıca üç ölçek arasında da anlamlı pozitif korelasyon olduğu görüldü (p<0,05). Behçet hastalarında hastalık aktivitesinin uyku kalitesi, depresyon düzeyi ve yaşam kalitesi açısından önemli bir belirleyici olduğu sonucuna varıldı. Hastalık aktivitesi kontrol altında tutularak Behçet hastalarının uyku kalitesi, depresyon düzeyi ve yaşam kalitesinin iyileştirilebileceği düşünülmektedir.Item Body mass index does not affect response to rituximab in patients with rheumatoid arthritis: Results from turkbio registry(Wiley, 2017-10) Koca, Süleyman Serdar; Karataş, Ahmet; Öz, Burak; Can, Gerçek; Yazıcı, Ayten; İnanç, Nevsun; Cefle, Ayşe; Ertürk, Zeypen; Akar, Servet; Şenel, Soner; Birlik, Merih; Akkoç, Nurullah; Önen, Fatoş; Dalkılıç, Ediz; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı/Romatoloji Anabilim Dalı.; CMF-4757-2022; AAG-8227-2021Item Characteristics predicting tuberculosis risk under tumor necrosis factor-α inhibitors: Report from a large multicenter cohort with high background prevalence(J. Rheumatol Publication, 2016-03) Pehlivan, Yavuz; Dalkılıç, Ediz; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Romatoloji Bilim Dalı.; AAG-8227-2021; 13205593600; 6506739457Objective. Screening strategies for latent tuberculosis (TB) before starting tumor necrosis factor (TNF)-alpha inhibitors have decreased the prevalence of TB among patients who are treated with these agents. However, despite vigilant screening, TB continues to be an important problem, especially in parts of the world with a high background TB prevalence. The aim of this study was to determine the factors related to TB among a large multicenter cohort of patients who were treated with anti-TNF. Methods. Fifteen rheumatology centers participated in this study. Among the 10,434 patients who were treated with anti-TNF between September 2002 and September 2012, 73 (0.69%) had developed TB. We described the demographic features and disease characteristics of these 73 patients and compared them to 7695 patients who were treated with anti-TNF, did not develop TB, and had complete data available. Results. Among the 73 patients diagnosed with TB (39 men, 34 women, mean age 43.6 +/- 13 yrs), the most frequent diagnoses were ankylosing spondylitis (n = 38) and rheumatoid arthritis (n = 25). More than half of the patients had extrapulmonary TB (39/73, 53%). Six patients died (8.2%). In the logistic regression model, types of anti-TNF drugs [infliximab (IFX), OR 3.4, 95% CI 1.88-6.10, p = 0.001] and insufficient and irregular isoniazid use (<9 mos; OR 3.15, 95% CI 1.43-6.9, p = 0.004) were independent predictors of TB development. Conclusion. Our results suggest that TB is an important complication of anti-TNF therapies in Turkey. TB chemoprophylaxis less than 9 months and the use of IFX therapy were independent risk factors for TB development.Publication Cigarette smoking does not affect treatment response to tofacitinib in rheumatoid arthritis(Wiley, 2018-09-01) Karataş, Ahmet; Öz, Burak; Dalkılıç, Ediz; Can, Gerçek; Pehlivan, Yavuz; Şenel, Soner; Yazıcı, Ayten; İnanç, Nevsun; Ertürk, Zeynep; Cefle, Ayşe; Akar, Servet; Koca, Süleyman Serdar; Birlik, Merih; Önen, Fatoş; DALKILIÇ, HÜSEYİN EDİZ; PEHLİVAN, YAVUZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bölümü; CMF-4757-2022; AAG-8227-2021Item The clinical and demographic features of relapsing polychondritis: A nationwide study(Bmj Publishing Group, 2016-06-10) Ermurat, Selime; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; ETI-3067-2022; AAG-8227-2021Item Comparing female-based contraceptive methods in patients with systemic lupus erythematosus, rheumatoid arthritis and a healthy population(Wiley, 2014-07) İnanç, Murat; Dalkılıç, Ediz; Tufan, Ayşe Nur; Öksüz, Mustafa Ferhat; Şahbazlar, Mustafa; Coşkun, Belkıs Nihan; Seniz, Nihan Belkıs; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı.; 0000-0003-0298-4157; AAG-7155-2021; AAG-8227-2021; 6506739457; 56076552900; 56016440100; 55260646400; 55646165400; 36087952200; 13205593600Aim: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is 10 times more prevalent in women, particularly those of reproductive age. The varying effects of pregnancy on SLE and the differences between available SLE treatments make pregnancy timing and contraceptive methods significant. We aimed to determine the contraceptive methods used by SLE patients in the north-west part of Turkey, and compared them with those used by rheumatoid arthritis (RA) patients and healthy controls. Method: The study was comprised of 113 SLE patients, and 84 RA patients at the Rheumatology Outpatient Clinic of Uludag University Medical Faculty. Results: Twenty-three (20.3%) out of 113 SLE patients, 18 (21.4%) out of 84 RA patients and 17 (18.6%) out of 92 healthy controls did not use any contraceptive methods. Use of the withdrawal and condom methods was more common among SLE patients, accounting for 61% (withdrawal 32.7%, condom 28.3%). Moreover, 52% of SLE and 50% of RA patients were neither given information about contraceptive methods nor offered a suggested method, compared to 34% in the health control group. Conclusions: The prevalence of oral contraceptive use is low in Turkey; notwithstanding the withdrawal and condom methods, which are frequently used despite their high failure risk. Although pregnancy timing is of great importance for SLE patients, necessary information and recommendations concerning contraceptive methods have been ignored and the use of effective methods is not a priority.Item Comparison of long term anti-tnf survival in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis; Data from Turkbio registry(Wiley, 2017-10) Can, Gerçek; Şenel, Soner; Akar, Servet; Solmaz, Dilek; Koca, Süleyman Serdar; İnanç, Nevsun; Atagündüz, Pamir; Yazıcı, Ayten; Cefle, Ayşe; Göker, Berna; Zengin, Berrin; Uslu, Sadettin; Akkoç, Nurullah; Önen, Fatoş; Dalkılıç, Ediz; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; CMF-4757-2022; AAG-8227-2021Item Comparison of long term anti-tnf survival in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis; data from Turkbio registry(BMJ Publishing Group, 2018-06) Can, Gerçek; Şenel, Soner; Akar, Servet; Solmaz, Dilek; Koca, Süleyman Serdar; İnanç, Nevsun; Atagündüz, Pamir; Yazıcı, Ayten; Cefle, Ayşe; Göker, Berna; Zengin, Berrin; Uslu, Sadettin; Akkoç, Nurullah; Önen, Fatoş; Dalkılıç, Ediz; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı/Romatoloji Bilim Dalı.; AAG-8227-2021Item Concomitant use of corticosteroids at the baseline does not affect the drug survival of abatacept in rheumatoid arthritis(BMJ, 2018-06) Koca, Süleyman Serdar; Öz, Burak; Karataş, Ahmet; Can, Gercek; Şenel, Soner; Yazıcı, Ayten; İnanç, Nevsun; Cefle, Ayşe; Ertürk, Zeynep; Akar, Servet; Göker, Berna; Birlik, Merih; Önen, Fatoş; Dalkılıç, Ediz; Pehlivan, Yavuz; Yağız, Burcu; Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı/Romatoloji Bilim Dalı.; AAG-8227-2021Item Corticosteroid Utilization before and after Initiation of biologic dmards between patients with rheumatoid arthritis(Wiley, 2018) Yağız, Burcu; Coşkun, Belkıs Nihan; Dalkılıç, Ediz; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bilim Dalı.; 0000-0003-0298-4157; AAG-7155-2021; AAG-8227-2021Item Dependency in activities of daily living in younger and older patients with rheumatoid arthritis(Clinical & Exper Rheumatology, 2014) Tufan, Fatih; Tufan, Ayşe Nur; Öksüz, Ferhat; Coşkun, Nihan Belkıs; Ermurat, Selime; Pehlivan, Yavuz; Dalkılıç, Ediz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Dahili Tıp Anabilim Dalı.; AAG-8227-2021; ABE-4424-2022Item Effects of anticoagulant treatment on the incidence of new vascular events in patients with behcet's disease with vascular involvement(Wiley, 2014-10) Seniz, Belkıs Nihan; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi.; AAG-8227-2021Publication Factors that may be associated with uveitis in patients with spondyloarthritis(Wiley, 2018-09-01) Kaşifoğlu, Timuçin; Bilge, Nazife Şule Yaşar; Kiraz, Sedat; Ertenli, İhsan; Küçükşahin, Orhan; Dalkılıc, Ediz; Bes, Cemal; Kanitez, Nilüfer Alpay; Atagündüz, Pamir; Coşkun, Belkıs Nihan; Yağız, Burcu; Koca, Süleyman Serdar; Çinar, Muhammed; Ateş, Aşkın; Akar, Servet; Gercik, Onay; Bakırlı, Duygu Ersözlü; Yazısız, Veli; Kimyon, Gezmiş; Tufan, Müge Aydın; Emmungil, Hakan; Mercan, Rıdvan; Bodakçı, Erdal; Öz, Burak; Akar, Zeynel Abidin; Karadağ, Ömer; Keleşoğlu, Bahar; Yılmaz, Sedat; İlgen, Ufuk; Pehlivan, Yavuz; Terzioğlu, Ender; Kılıç, Levent; Erten, Şükran; Taşçılar, Koray; Kalyoncu, Umut; DALKILIÇ, HÜSEYİN EDİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahili Tıp Bölümü; CMF-4757-2022Item Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis(Public Library Science, 2019-04-04) Pehlivan, Yavuz; Dalkılıç, Ediz; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri/İç Hastalıkları Ana Bilim Dalı.; AAG-8227-2021; 57220381538; 6506739457Ankylosing spondylitis (AS) is a highly heritable immune-mediated arthritis common in Turkish and Iranian populations. Familial Mediterranean Fever (FMF) is an autosomal recessive autoinflammatory disease most common in people of Mediterranean origin. MEFV, an FMF-associated gene, is also a candidate gene for AS. We aimed to identify AS susceptibility loci and also examine the association between MEFV and AS in Turkish and Iranian cohorts. We performed genome-wide association studies in 1001 Turkish AS patients and 1011 Turkish controls, and 479 Iranian AS patients and 830 Iranian controls. Serum IL-1, IL-17 and IL-23 cytokine levels were quantified in Turkish samples. An association of major effect was observed with a novel rare coding variant in MEFV in the Turkish cohort (rs61752717, M694V, OR = 5.3, P = 7.63x10(-12)), Iranian cohort (OR = 2.9, P = 0.042), and combined dataset (OR = 5.1, P = 1.65x10(-13)). 99.6% of Turkish AS cases, and 96% of those carrying MEFV rs61752717 variants, did not have FMF. In Turkish subjects, the association of rs61752717 was particularly strong in HLA-B27-negative cases (OR = 7.8, P = 8.93x10(-15)), but also positive in HLA-B27-positive cases (OR = 4.3, P = 7.69x10(-8)). Serum IL-1, IL-17 and IL-23 levels were higher in AS cases than controls. Among AS cases, serum IL-1 and IL-23 levels were increased in MEFV 694V carriers compared with non-carriers. Our data suggest that FMF and AS have overlapping aetiopathogenic mechanisms. Functionally important MEFV mutations, such as M694V, lead to dysregulated inflammasome function and excessive IL-1 function. As IL-1 inhibition is effective in FMF, AS cases carrying FMF-associated MEFV variants may benefit from such therapy. Author summary Ankylosing spondylitis (AS) is a highly heritable immune-mediated arthritis. To identify new genetic associations with AS, we performed genome-wide association studies in Turkish and Iranian AS patients and controls. We identified a novel rare coding MEFV variant associated with AS. Rare polymorphisms of MEFV, which encodes the protein pyrin, are known to cause Familial Mediterranean Fever (FMF), a monogenic, autosomal recessive, autoinflammatory disease which can be complicated by arthritis. 99.6% of Turkish AS cases, and 96% of those carrying the MEFV variant, did not have FMF, and the association with AS remains excluding cases with FMF. In Turkish subjects, the MEFV variant association was particularly strong in HLA-B27-negative cases, but also positive in HLA-B27-positive cases. This represents the first rare variant association with AS, and has the highest odds ratio for AS of any non-MHC reported hitherto, indicating a major effect on disease pathogenesis. We assessed serum cytokine levels in the cohort, and found that IL-1, IL-17 and IL-23 levels were higher in AS cases. Furthermore, among AS cases, IL-1 and IL-23 levels were increased in MEFV variant carriers compared with non-carriers. This study has therapeutic implications; as IL-1 inhibition is effective in FMF, AS cases carrying FMF-associated MEFV variants may benefit from such therapy.Item Hairy cell leukemia presenting initially with symptoms of Behcet's disease(Wiley, 2014-07) Öksüz, Mustafa Ferhat; Coşkun, Belkıs Nihan; Tufan, Ayşe Nur; Oruçoğlu, Nurdan; Dalkılıç, Ediz; Öztürk Nazlıoğlu, Hülya; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0003-0298-4157; AAG-8227-2021; AAG-7155-2021; 56016440100; 55646165400; 56076552900; 57199625557; 6506739457; 56124533600; 13205593600Vasculitis is relatively uncommon in lymphoproliferative disease and may predate the diagnosis of lymphoproliferative disease. Many vasculitides have been associated with hairy cell leukemia (HCL), including polyarteritis nodosa (PAN) and leukocytoclastic vasculitis. We herein report a case whose initial presentation was like Behcet's disease (BD) (arthritis, oral and genital ulcerations, papulopustular skin lesions) in addition to pancytopenia, but turned out to have HCL. Because of the overlap between their symptoms, like oral ulcerations, skin lesions, arthritis and constitutional findings, HCL and BD may mimic each other. We should keep in mind other reasons for vasculitis such as lymphoproliferative disease, especially whose who have hematological abnormalities such as pancytopenia.