Molecular cytogenetic findings in cases with childhood acute lymphoblastic leukemia

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dc.contributor.buuauthorKarkucak, Mutlu
dc.contributor.buuauthorGörukmez, Orhan
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorBaytan, Birol
dc.contributor.buuauthorGörükmez, Özlem
dc.contributor.buuauthorGüneş, Adalet Meral
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Çocuk Hematolojisi Anabilim Dalı.tr_TR
dc.contributor.researcheridAFZ-0764-2022tr_TR
dc.contributor.scopusid35388323500tr_TR
dc.contributor.scopusid56681045900tr_TR
dc.contributor.scopusid6602802424tr_TR
dc.contributor.scopusid6506622162tr_TR
dc.contributor.scopusid57188923466tr_TR
dc.contributor.scopusid24072843300tr_TR
dc.date.accessioned2022-04-08T06:30:35Z
dc.date.available2022-04-08T06:30:35Z
dc.date.issued2012
dc.description.abstractAcute lymphoblastic leukemia (ALL) is the most common malignancy in children and is usually associated with numerical and structural chromosomal changes. Although some of these changes are accepted as favorable or poor prognostic factors, the prognostic effects of others have not been well determined. In our study, we aimed to present the chromosomal changes in cases with childhood ALL and their ratios in hematologic risk groups. Thirty four patients with childhood ALL were included in the study. Subjects were diagnosed with fluorescence in situ hybridization (FISH) analysis by using standard translocation, deletion and aneuploidy probes. The chromosomal changes obtained from our analysis were classified into hematologic risk groups and their ratios were evaluated. In our study, we found that the t(12.21) translocation was the most common abnormality in minimal and standard risk groups, whereas the 9p21 deletion was the most common abnormality among high-risk patients.en_US
dc.identifier.citationKarkucak, M. vd. (2012). "Molecular cytogenetic findings in cases with childhood acute lymphoblastic leukemia". UHOD-Uluslararasi Hematoloji-Onkoloji Dergisi, 22(2), 67-72.tr_TR
dc.identifier.endpage72tr_TR
dc.identifier.issn1306-133X
dc.identifier.issue2tr_TR
dc.identifier.scopus2-s2.0-84863876001tr_TR
dc.identifier.startpage67tr_TR
dc.identifier.urihttps://doi.org/10.4999/uhod.11045
dc.identifier.urihttp://www.uhod.org/pdf/PDF_516.pdf
dc.identifier.urihttp://hdl.handle.net/11452/25656
dc.identifier.volume22tr_TR
dc.identifier.wos000306389300001tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.trdizinTrDizintr_TR
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherAkad Doktorlar Yayınevitr_TR
dc.relation.journalUHOD-Uluslararasi Hematoloji-Onkoloji Dergisitr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOncologyen_US
dc.subjectAcute lymphoblastic leukemiaen_US
dc.subjectMolecular cytogeneticen_US
dc.subjectChromosomal anomalyen_US
dc.subjectHigh hyperdiploidyen_US
dc.subjectChildrenen_US
dc.subjectRearrangementsen_US
dc.subjectAbnormalitiesen_US
dc.subjectGenesen_US
dc.subjectP15en_US
dc.subjectAkut lenfoblastik lösemitr_TR
dc.subjectKromozomal anomalitr_TR
dc.subjectMoleküler sitogenetiktr_TR
dc.subject.emtreeAcute lymphoblastic leukemiaen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAneuploidyen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeChildhood leukemiaen_US
dc.subject.emtreeChromosome analysisen_US
dc.subject.emtreeChromosome deletionen_US
dc.subject.emtreeChromosome translocationen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeCytogeneticsen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFluorescence in situ hybridizationen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePreschool childen_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeSchool childen_US
dc.subject.scopusAcute Lymphoblastic Leukemia; Chromosome 21; Pre B Lymphocyteen_US
dc.subject.wosOncologyen_US
dc.titleMolecular cytogenetic findings in cases with childhood acute lymphoblastic leukemiaen_US
dc.title.alternativeÇocukluk çaği akut lenfoblastik lösemili olgularda moleküler sitogenetik bulgulartr_TR
dc.typeArticle
dc.wos.quartileQ4en_US

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