Molecular cytogenetic findings in cases with childhood acute lymphoblastic leukemia
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Date
2012
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Akad Doktorlar Yayınevi
Abstract
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children and is usually associated with numerical and structural chromosomal changes. Although some of these changes are accepted as favorable or poor prognostic factors, the prognostic effects of others have not been well determined. In our study, we aimed to present the chromosomal changes in cases with childhood ALL and their ratios in hematologic risk groups. Thirty four patients with childhood ALL were included in the study. Subjects were diagnosed with fluorescence in situ hybridization (FISH) analysis by using standard translocation, deletion and aneuploidy probes. The chromosomal changes obtained from our analysis were classified into hematologic risk groups and their ratios were evaluated. In our study, we found that the t(12.21) translocation was the most common abnormality in minimal and standard risk groups, whereas the 9p21 deletion was the most common abnormality among high-risk patients.
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Keywords
Oncology, Acute lymphoblastic leukemia, Molecular cytogenetic, Chromosomal anomaly, High hyperdiploidy, Children, Rearrangements, Abnormalities, Genes, P15, Akut lenfoblastik lösemi, Kromozomal anomali, Moleküler sitogenetik
Citation
Karkucak, M. vd. (2012). "Molecular cytogenetic findings in cases with childhood acute lymphoblastic leukemia". UHOD-Uluslararasi Hematoloji-Onkoloji Dergisi, 22(2), 67-72.