Prion protein gene (PrP) polymorphisms in healthy sheep in Turkey

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dc.contributor.buuauthorÖner, Yasemin
dc.contributor.buuauthorTuncel, Erdoǧan
dc.contributor.buuauthorYeşi̇lbağ, Kadir
dc.contributor.buuauthorElmacı, Cengiz
dc.contributor.departmentUludağ Üniversitesi/Ziraat Fakültesi/Hayvan Bilimleri Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veterinerlik Fakültesi/Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-4819-0221tr_TR
dc.contributor.orcid0000-0002-2904-8986tr_TR
dc.contributor.researcheridABE-7662-2020tr_TR
dc.contributor.researcheridABB-3181-2020tr_TR
dc.contributor.researcheridV-7882-2019tr_TR
dc.contributor.scopusid9634793800tr_TR
dc.contributor.scopusid7006929824tr_TR
dc.contributor.scopusid6602912127tr_TR
dc.contributor.scopusid6602597697tr_TR
dc.date.accessioned2022-01-04T11:40:51Z
dc.date.available2022-01-04T11:40:51Z
dc.date.issued2011-09
dc.description.abstractScrapie, a transmissible spongiform encephalopathy (TSE) or prion disease, is a fatal, neurodegenerative disease in sheep and goats. This disease has been known in Europe for more than 250 years. Susceptibility to scrapie is associated with polymorphisms in the sheep prion protein gene (PrP) gene. In sheep, polymorphism in the PrP gene has been identified at a number of codons, and polymorphisms at codons 136, 154 and 171 have reported linkage with susceptibility to scrapie. Polymorphisms at the PrP locus were studied in 413 animals representing three native sheep breeds (Imroz, Chios and Kivircik) in Turkey. Genomic DNA was obtained from blood, and genotypes were screened using PCR and direct DNA sequencing. We report 17 genotypes derived from seven different alleles. The most frequent genotype in the kivircik sheep is ARQ/ARQ, whereas the ARR/ARQ genotype is predominant in the Chios and Imroz breeds. In general, the ARQ haplotype was the predominant haplotype. ARQ haplotype was also predominant in the kivircik and Chios sheep breeds, whereas the Imroz sheep predominantly had the ARR haplotype. The susceptibility-associated VRQ haplotype was found in 2.38%, 0.35% and 0.81% of the Imroz, kivircik and Chios sheep, respectively. Moreover, seven additional polymorphisms have been detected at codons G127S, G127V, H143R, G145S, Y172D, N174Y and Q189L. Among these polymorphisms, the N174Y allele is a novel polymorphism, and the G145S allele is a novel allele for a known polymorphic locus.en_US
dc.identifier.citationÖner, Y. vd. (2011). "Prion protein gene (PrP) polymorphisms in healthy sheep in Turkey". Animal, 5(11), 1728-1733.en_US
dc.identifier.endpage1733tr_TR
dc.identifier.issn1751-7311
dc.identifier.issn1751-732X
dc.identifier.issue11tr_TR
dc.identifier.pubmed22440412tr_TR
dc.identifier.scopus2-s2.0-84877985525tr_TR
dc.identifier.startpage1728tr_TR
dc.identifier.urihttps://doi.org/10.1017/S1751731111000942
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1751731111000942
dc.identifier.urihttp://hdl.handle.net/11452/23845
dc.identifier.volume5tr_TR
dc.identifier.wos000296091200006tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.bapZ-2007/7tr_TR
dc.relation.journalAnimalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitakTOVAG 106 O 718tr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgricultureen_US
dc.subjectVeterinary sciencesen_US
dc.subjectSheepen_US
dc.subjectScrapieen_US
dc.subjectPrPen_US
dc.subjectPolymorphismen_US
dc.subjectSusceptibilityen_US
dc.subjectNatural scrapieen_US
dc.subjectGenotypeen_US
dc.subjectSequenceen_US
dc.subjectSusceptibilityen_US
dc.subjectFrequenciesen_US
dc.subjectResistanceen_US
dc.subjectAllelesen_US
dc.subjectAgenten_US
dc.subjectBreeden_US
dc.subjectHosten_US
dc.subject.scopusChronic Wasting Disease; Scrapie; Prion Proteinsen_US
dc.subject.wosAgriculture, dairy & animal scienceen_US
dc.subject.wosVeterinary sciencesen_US
dc.titlePrion protein gene (PrP) polymorphisms in healthy sheep in Turkeyen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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