Treatment results of 165 pediatric patients with non-metastatic nasopharyngeal carcinoma: A rare cancer network study

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dc.contributor.authorÖzyar, Enis
dc.contributor.authorSelek, Uğur
dc.contributor.authorLaskar, Siddihartha
dc.contributor.authorUzel, Ömer
dc.contributor.authorAnacak, Yavuz
dc.contributor.authorBen-Arush, Miriam
dc.contributor.authorPolychronopoulou, Sopiha
dc.contributor.authorAkman, Fadime
dc.contributor.authorWolden, Suzanne
dc.contributor.authorAbacıoğlu, Ufuk
dc.contributor.authorMiller, Robert C.
dc.contributor.authorÖzşahin, Mahmut
dc.contributor.authorAbacıoğlu, Ufuk
dc.contributor.authorMartin, Margarita
dc.contributor.authorCaloğlu, Murat
dc.contributor.authorScandolaro, Luciano
dc.contributor.authorSzutowicz, Eva
dc.contributor.authorAtahan, Ibtisam Lale
dc.contributor.buuauthorSarıhan, Süreyya
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi.tr_TR
dc.contributor.researcheridAAH-4970-2021tr_TR
dc.contributor.scopusid56404684500
dc.date.accessioned2021-08-27T08:35:42Z
dc.date.available2021-08-27T08:35:42Z
dc.date.issued2006
dc.description.abstractPurpose: This Rare Cancer Network (RCN) study was performed in pediatric nasopharyngeal carcinoma (PNPC) patients to evaluate the optimal dose of radiotherapy and to determine prognostic factors. Patients and Methods: The study included 165 patients with the diagnosis of PNPC treated between 1978 and 2003. The median age was 14 years. There were 3 (1.8%) patients with stage I, 1 (0.6%) with IIA, 10 (6.1%) with IIB, 60 (36.4%) with III, 44 (26.7%) with IVA, and 47 (29%) with IVB disease. While 21 (12.7%) patients were treated with radiotherapy (RT) alone, 144 (87.3%) received chemotherapy and RT. The median follow-up time was 48 months. Results: The actuarial 5-year overall survival (OS) was 77.4% (95% CI: 70.06-84.72), whereas the actuarial 5-year disease-free survival (DFS) rate was 68.8% (95% CI: 61.33-76.31). In multivariate analysis, unfavorable factors were age > 14 years for LRC (p = 0.04); mate gender for DMFS (p = 0.03); T3/T4 disease for LRFS (p = 0.01); and N3 disease for DFS (p = 0.002) and OS (p = 0.002); EBRT dose of less than 66 Gy for LRFS (p = 0.02) and LRRFS (p = 0.0028); and patients treated with RT alone for LRFS (p = 0.0001), LRRFS (p = 0.007) and DFS (p = 0.02). Conclusion: Our results support the current practice of using combined radiation and chemotherapy for optimal treatment of NPC. However, research should be encouraged in an attempt to reduce the potential for long-term sequelae in pediatric patients given their relatively favorable prognosis and potential for longevity.en_US
dc.identifier.citationÖzyar, E. vd. (2006). ''Treatment results of 165 pediatric patients with non-metastatic nasopharyngeal carcinoma: A Rare Cancer Network study''. Radiotherapy and Oncology, 81(1), 39-46.en_US
dc.identifier.endpage46tr_TR
dc.identifier.issn0167-8140
dc.identifier.issn1879-0887
dc.identifier.issue1tr_TR
dc.identifier.pubmed16965827tr_TR
dc.identifier.scopus2-s2.0-33749443724tr_TR
dc.identifier.startpage39tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.radonc.2006.08.019
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0167814006003987
dc.identifier.urihttp://hdl.handle.net/11452/21550
dc.identifier.volume81tr_TR
dc.identifier.wos000241846600006tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Irelanden_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalRadiotherapy and Oncologytr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadiology, nuclear medicine & medical imagingen_US
dc.subjectOncologyen_US
dc.subjectRareen_US
dc.subjectPediatricen_US
dc.subjectRadiotherapyen_US
dc.subjectNasopharynx canceren_US
dc.subjectCisplatinen_US
dc.subjectExperienceen_US
dc.subjectYoungen_US
dc.subjectAdolescenceen_US
dc.subjectRadiotherapyen_US
dc.subject.wosOncologyen_US
dc.subject.wosRadiology, nuclear medicine & medical imagingen_US
dc.titleTreatment results of 165 pediatric patients with non-metastatic nasopharyngeal carcinoma: A rare cancer network studyen_US
dc.typeArticle
dc.wos.quartileQ2 (Oncology)en_US
dc.wos.quartileQ1 (Radiology, nuclear medicine & medical imaging)en_US

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