Reference intervals: Current status, recent developments and future considerations

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dc.contributor.buuauthorÖzarda, Yeşim
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.scopusid35741320500tr_TR
dc.date.accessioned2022-05-25T08:53:41Z
dc.date.available2022-05-25T08:53:41Z
dc.date.issued2016
dc.description.abstractReliable and accurate reference intervals (RIs) for laboratory analyses are an integral part of the process of correct interpretation of clinical laboratory test results. RIs given in laboratory reports have an important role in aiding the clinician in interpreting test results in reference to values for healthy populations. Since the 1980s, the International Federation of Clinical Chemistry (IFCC) has been proactive in establishing recommendations to clarify the true significance of the term 'RIs, to select the appropriate reference population and statistically analyse the data. The C28-A3 guideline published by the Clinical and Laboratory Standards Institute (CLSI) and IFCC is still the most widely-used source of reference in this area. In recent years, protocols additional to the Guideline have been published by the IFCC, Committee on Reference Intervals and Decision Limits (C-RIDL), including all details of multicenter studies on RIs to meet the requirements in this area. Multicentric RIs studies are the most important development in the area of RIs. Recently, the C-RIDL has performed many multicentric studies to obtain common RIs. Confusion of RIs and clinical decision limits (CDLs) remains an issue and pediatric and geriatric age groups are a significant problem. For future studies of RIs, the genetic effect would seem to be the most challenging area. The aim of the review is to present the current theory and practice of RIs, with special emphasis given to multicenter RIs studies, RIs studies for pediatric and geriatric age groups, clinical decision limits and partitioning by genetic effects on RIs.en_US
dc.identifier.citationÖzarda, Y. (2016). "Reference intervals: Current status, recent developments and future considerations". Biochemia Medica, 26(1), 5-16.en_US
dc.identifier.endpage16tr_TR
dc.identifier.issn1330-0962
dc.identifier.issn1846-7482
dc.identifier.issue1tr_TR
dc.identifier.pubmed26981015tr_TR
dc.identifier.scopus2-s2.0-84957927107tr_TR
dc.identifier.startpage5tr_TR
dc.identifier.urihttps://doi.org/10.11613/BM.2016.001
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783089/
dc.identifier.urihttp://hdl.handle.net/11452/26683
dc.identifier.volume26tr_TR
dc.identifier.wos000370676600001tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherCroatian Soc Medical Biochemistry & Laboratory Medicineen_US
dc.relation.journalBiochemia Medicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMedical laboratory technologyen_US
dc.subjectMulticenter studyen_US
dc.subjectCommon reference intervalsen_US
dc.subjectReference valuesen_US
dc.subjectClinical decision limitsen_US
dc.subjectGenetic informationen_US
dc.subjectLaboratory reference intervalsen_US
dc.subjectPediatric reference intervalsen_US
dc.subjectApproved recommendation 1987en_US
dc.subjectCommon reference intervalsen_US
dc.subjectHospital patient dataen_US
dc.subjectCollaborative derivationen_US
dc.subjectWorldwide multicenteren_US
dc.subjectBiological variationen_US
dc.subjectClinical-chemistryen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeClinical chemistryen_US
dc.subject.emtreeClinical trialen_US
dc.subject.emtreeControlled clinical trialen_US
dc.subject.emtreeHeredityen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMulticenter studyen_US
dc.subject.emtreePractice guidelineen_US
dc.subject.emtreeReference valueen_US
dc.subject.emtreeTheoretical modelen_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeDiagnostic testen_US
dc.subject.emtreeGeriatricsen_US
dc.subject.emtreeLaboratory techniquetr_TR
dc.subject.emtreePediatricsen_US
dc.subject.emtreePractice guidelineen_US
dc.subject.emtreeProceduresen_US
dc.subject.emtreeReference valueen_US
dc.subject.emtreeStandardsen_US
dc.subject.emtreeStatistics and numerical dataen_US
dc.subject.meshAgeden_US
dc.subject.meshChemistry, clinicalen_US
dc.subject.meshChilden_US
dc.subject.meshClinical laboratory techniquesen_US
dc.subject.meshDiagnostic tests, routineen_US
dc.subject.meshGeriatricsen_US
dc.subject.meshGuidelines as topicen_US
dc.subject.meshHumansen_US
dc.subject.meshPediatricsen_US
dc.subject.meshReference valuesen_US
dc.subject.scopusClinical Chemistry; Thyrotropin; Chemical Speciesen_US
dc.subject.wosMedical laboratory technologyen_US
dc.titleReference intervals: Current status, recent developments and future considerationsen_US
dc.typeReview
dc.wos.quartileQ2en_US

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