A new material for prevention of epidural fibrosis after laminectomy - Oxidized regenerated cellulose (Interceed), an absorbable barrier

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dc.contributor.buuauthorTemel, Şehime G.
dc.contributor.buuauthorÖztürk, Çağatay
dc.contributor.buuauthorTemiz, Aytun
dc.contributor.buuauthorErsözlü, Salim
dc.contributor.buuauthorAydınlı, Ufuk
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Ortopedik Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Tıbbi Genetik Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-3133-206Xtr_TR
dc.contributor.researcheridS-6686-2019tr_TR
dc.contributor.researcheridAAG-8385-2021tr_TR
dc.date.accessioned2021-09-09T09:04:09Z
dc.date.available2021-09-09T09:04:09Z
dc.date.issued2006
dc.description.abstractEpidural fibrosis, which may cause persistent back and leg pain, may develop after laminectomy. Several materials have been used in attempts to minimize epidural fibrosis, with varying results. We evaluated the efficacy of an absorbable cellulose adhesion barrier in preventing epidural fibrosis. In 25 New Zealand white rabbits, laminectomies were performed at L3 and L5 vertebrae. The dura mater was covered by the adhesion barrier (Interceed, TC7, Johnson & Johnson, USA) at L3 laminectomy site (group 1), with L5 laminectomy site serving as an internal control (group 2) in each animal. There was no neurological deficit in any of the animals during the postoperative period. Animals were sacrificed at postoperative day 28. The lumbar spine was removed en bloc and placed in neutral, buffered formalin for 72 h. The specimens were then decalcified and embedded in paraffin. Permanent sections of 5 to 7 mu m were stained with hematoxylin and eosin and Masson trichrome dye. Epidural fibrosis was evaluated in a double-blinded manner. The extent of epidural fibrosis was graded as 0, no reaction seen; 1, mild reaction; 2, moderate reaction; 3, extensive reaction, and 4, severe reaction. The histological findings of each group were compared. For the statistical analysis, Wilcoxon signed rank test was used. In group 1, the fibrotic tissue formation was minimal in 19 and moderate in 6 laminectomy sites. In group 2, the fibrotic tissue formation was determined as being extensive in 17 and moderate in 8 laminectomy sites. Statistical analysis showed significant decrease in epidural fibrosis in group 1 (P < 0.05). This study showed that Interceed, which is commercially available in the market, especially for abdominal and gynecological surgeries, could be used to prevent epidural fibrosis.en_US
dc.identifier.citationTemel, Ş. G. vd. (2006). ''A new material for prevention of epidural fibrosis after laminectomy - Oxidized regenerated cellulose (Interceed), an absorbable barrier''. Journal of Spinal Disorders and Techniques, 19(4), 270-275.en_US
dc.identifier.endpage275tr_TR
dc.identifier.issn1536-0652
dc.identifier.issn1539-2465
dc.identifier.issue4tr_TR
dc.identifier.pubmed16778662tr_TR
dc.identifier.scopus2-s2.0-33746557597tr_TR
dc.identifier.startpage270tr_TR
dc.identifier.urihttps://doi.org/10.1097/01.bsd.0000203946.11546.d9
dc.identifier.urihttps://journals.lww.com/jspinaldisorders/Fulltext/2006/06000/A_New_Material_for_Prevention_of_Epidural_Fibrosis.8.aspx#
dc.identifier.urihttp://hdl.handle.net/11452/21802
dc.identifier.volume19tr_TR
dc.identifier.wos000238242000008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.journalJournal of Spinal Disorders and Techniquesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectOrthopedicsen_US
dc.subjectNeurological deficiten_US
dc.subjectLaminectomyen_US
dc.subjectEpidural fibrosisen_US
dc.subjectDuraen_US
dc.subjectAdhesion barrieren_US
dc.subjectDiskectomyen_US
dc.subjectTransplantsen_US
dc.subjectProphylaxisen_US
dc.subjectMembraneen_US
dc.subjectAdhesionsen_US
dc.subjectFat graften_US
dc.subjectPeridural fibrosisen_US
dc.subjectLumbar spine surgeryen_US
dc.subjectCauda-equina syndromeen_US
dc.subjectPostlaminectomy scar formationen_US
dc.subject.scopusLaminectomy; Failed Back Surgery Syndrome; Dura Materen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosOrthopedicsen_US
dc.titleA new material for prevention of epidural fibrosis after laminectomy - Oxidized regenerated cellulose (Interceed), an absorbable barrieren_US
dc.typeArticle
dc.wos.quartileQ3en_US

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