Short and long term effects of granulocyte colony-stimulating factor during induction therapy in acute myeloid leukemia patients younger than 65: Results of a randomized multicenter phase III trial

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dc.contributor.authorBeksaç, Meral
dc.contributor.authorÖzcan, Muhit
dc.contributor.authorÖzçebe, Osman
dc.contributor.authorBayık, Mahmut
dc.contributor.authorPaydaş, Semra
dc.contributor.authorBüyükaşık, Yahya
dc.contributor.authorİlhan, Osman
dc.contributor.authorGürman, Günhan
dc.contributor.authorUysal, Akın
dc.contributor.authorAkan, Hamdi
dc.contributor.authorSoydan, Ender Akcağlayan
dc.contributor.buuauthorAli, Ridvan
dc.contributor.buuauthorÖzçelik, Tülay
dc.contributor.buuauthorÖzkalemkaş, Fahir
dc.contributor.buuauthorTunalı, Ahmet
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Hematoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAG-8495-2021tr_TR
dc.contributor.scopusid7201813027tr_TR
dc.contributor.scopusid7005424333tr_TR
dc.contributor.scopusid6601912387tr_TR
dc.date.accessioned2022-03-16T06:25:28Z
dc.date.available2022-03-16T06:25:28Z
dc.date.issued2011-03
dc.description.abstractThis prospective multicenter phase III clinical trial was designed to assess efficacy and safety of G-CSF as an adjunct to de novo AML remission induction therapy (www.clinicaltrials.gov.NCT00820976). Patients' characteristics were similar in both arms. G-CSF improved severity and duration of leukopenia. Three-year OS were similar (25.6 +/- 5.1% vs. 31.8 +/- 5.6%) in both arms except for patients with myeloblastic features. Significant factors for better survival were the use of G-CSF (p = 0.049), female sex (p = 0.05) and single induction cycle (p < 0.001) in multivariate analysis. Female patients performed better than male patients. Better survival obtained among female AML patients needs to be validated within the context of cytogenetic analysis.en_US
dc.identifier.citationBeksaç, M. vd. (2011). "Short and long term effects of granulocyte colony-stimulating factor during induction therapy in acute myeloid leukemia patients younger than 65: Results of a randomized multicenter phase III trial". Leukemia Research, 35(3), 340-345.en_US
dc.identifier.endpage345tr_TR
dc.identifier.issn0145-2126
dc.identifier.issn1873-5835
dc.identifier.issue3tr_TR
dc.identifier.pubmed20673585tr_TR
dc.identifier.scopus2-s2.0-79952105259tr_TR
dc.identifier.startpage340tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.leukres.2010.07.005
dc.identifier.urihttp://hdl.handle.net/11452/25062
dc.identifier.volume35tr_TR
dc.identifier.wos000287965100019tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSSCIen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Scienceen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalLeukemia Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOncologyen_US
dc.subjectHematologyen_US
dc.subjectGranulocyte colony-stimulating factoren_US
dc.subjectAcute myeloid leukemiaen_US
dc.subjectInductionen_US
dc.subjectSurvivalen_US
dc.subjectAcute myelogenous leukemiaen_US
dc.subjectPlacebo-controlled trialen_US
dc.subjectSouthwest-oncology-groupen_US
dc.subjectElderly-patientsen_US
dc.subjectDouble-blinden_US
dc.subjectAdult patientsen_US
dc.subjectGrowth-factorsen_US
dc.subjectG-csfen_US
dc.subjectFebrile neutropeniaen_US
dc.subjectPrognostic-factorsen_US
dc.subject.emtreeCytarabineen_US
dc.subject.emtreeIdarubicinen_US
dc.subject.emtreeRecombinant granulocyte colony stimulating factoren_US
dc.subject.emtreeAcute febrile neutrophilic dermatosisen_US
dc.subject.emtreeAcute granulocytic leukemiaen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAllogeneic peripheral blood stem cell transplantationen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAutologous peripheral blood stem cell transplantationen_US
dc.subject.emtreeBone marrow biopsyen_US
dc.subject.emtreeCapillary leak syndromeen_US
dc.subject.emtreeChromosome analysisen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease durationen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeDrug eruptionen_US
dc.subject.emtreeDrug feveren_US
dc.subject.emtreeDrug safetyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeInfectionen_US
dc.subject.emtreeLeukemia remissionen_US
dc.subject.emtreeLeukopeniaen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMulticenter studyen_US
dc.subject.emtreeMultiple cycle treatmenten_US
dc.subject.emtreeMusculoskeletal painen_US
dc.subject.emtreeMyoblasten_US
dc.subject.emtreeNeutrophil counten_US
dc.subject.emtreeOverall survivalen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProspective studyen_US
dc.subject.emtreeRandomized controlled trialen_US
dc.subject.emtreeSex differenceen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshDrug resistance, neoplasmen_US
dc.subject.meshFemaleen_US
dc.subject.meshGranulocyte colony-stimulating factoren_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, myeloid, acuteen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshNeoplasm recurrence, localen_US
dc.subject.meshNeutropeniaen_US
dc.subject.meshRemission inductionen_US
dc.subject.meshSurvival rateen_US
dc.subject.meshTime factorsen_US
dc.subject.meshTreatment outcomeen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusCytarabine; Acute Myeloid Leukemia; Remissionen_US
dc.subject.wosOncologyen_US
dc.subject.wosHematologyen_US
dc.titleShort and long term effects of granulocyte colony-stimulating factor during induction therapy in acute myeloid leukemia patients younger than 65: Results of a randomized multicenter phase III trialen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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