IL-1 cluster gene polymorphisms in Turkish patients with Behçet's disease

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dc.contributor.authorÖzçimen, Ahmet Ata
dc.contributor.buuauthorDilek, Kamil
dc.contributor.buuauthorBingöl, Ümit
dc.contributor.buuauthorSarıcaoğlu, Hayriye
dc.contributor.buuauthorSarandöl, Aslı
dc.contributor.buuauthorTaşkapılıoğlu, Özlem
dc.contributor.buuauthorYurtkuran, Merih M.
dc.contributor.buuauthorYurtkuran, Mustafa Abbas
dc.contributor.buuauthorOral, Haluk Barbaros
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nefroloji ve Romatoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.orcid0000-0003-4436-3797tr_TR
dc.contributor.researcheridAAK-6623-2020tr_TR
dc.contributor.researcheridK-7285-2012tr_TR
dc.contributor.researcheridX-4479-2018tr_TR
dc.contributor.scopusid56005080200tr_TR
dc.contributor.scopusid6507727900tr_TR
dc.contributor.scopusid6603722836tr_TR
dc.contributor.scopusid14020405100tr_TR
dc.contributor.scopusid23037226400tr_TR
dc.contributor.scopusid55408539300tr_TR
dc.contributor.scopusid7003389525tr_TR
dc.contributor.scopusid7004498001tr_TR
dc.date.accessioned2021-12-23T11:03:20Z
dc.date.available2021-12-23T11:03:20Z
dc.date.issued2011-08
dc.description.abstractSeveral cytokine genes may play crucial roles in host susceptibility to Behcet's Disease (BD), since the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphisms. The association of the IL-1 cluster gene polymorphisms with the development of BD was investigated in this study. DNA samples were obtained from a Turkish population of 97 patients with BD, and 77 healthy control subjects. All genotyping (IL-1 alpha, IL-1 beta, IL-1R and IL-1Ra) experiments were performed using sequence specific primers PCR (PCR-SSP). When compared to the healthy controls, the frequencies of IL-1Ra IL-1 alpha and IL-1R gene polymorphisms were not significantly different in BD patients. The frequency of IL-1 beta -511 TT genotype was higher in the BD group in comparison to the control group. Interestingly, we demonstrated that IL-1 beta +3962 gene polymorphism seems to be associated with the presence of Erythema nodosum in BD patients. Our data suggest that polymorphisms in IL-1 beta gene may affect host susceptibility to BD. In order to confirm the biological significance of our results, further studies should be performed in a large-scale study and/or in different ethnic groups.en_US
dc.identifier.citationÖzçimen, A. A. vd. (2011). "IL-1 cluster gene polymorphisms in Turkish patients with Behçet's disease". International Journal of Immunogenetics, 38(4), 295-301.en_US
dc.identifier.endpage301tr_TR
dc.identifier.issn1744-3121
dc.identifier.issue4tr_TR
dc.identifier.pubmed21418526tr_TR
dc.identifier.scopus2-s2.0-79959944004tr_TR
dc.identifier.startpage295tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1744-313X.2011.01006.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1744-313X.2011.01006.x
dc.identifier.urihttp://hdl.handle.net/11452/23505
dc.identifier.volume38tr_TR
dc.identifier.wos000292335800005tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.bapT-2004/59tr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.journalInternational Journal of Immunogeneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGenetics & heredityen_US
dc.subjectImmunologyen_US
dc.subjectInterleukin-1 receptor antagonisten_US
dc.subjectInflammatory-bowel-diseaseen_US
dc.subjectIfn-gamma geneen_US
dc.subjectIn-vitroen_US
dc.subjectNucleotide-sequenceen_US
dc.subjectCytokine productionen_US
dc.subjectOnline databasesen_US
dc.subjectLong armen_US
dc.subjectAssociationen_US
dc.subjectRisken_US
dc.subject.emtreeInterleukin 1 receptoren_US
dc.subject.emtreeInterleukin 1 receptor blocking agenten_US
dc.subject.emtreeInterleukin 1alphaen_US
dc.subject.emtreeInterleukin 1betaen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBehcet diseaseen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease associationen_US
dc.subject.emtreeDisease courseen_US
dc.subject.emtreeDisease predispositionen_US
dc.subject.emtreeDNA polymorphismen_US
dc.subject.emtreeErythema nodosumen_US
dc.subject.emtreeEthnic differenceen_US
dc.subject.emtreeEthnic groupen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGene clusteren_US
dc.subject.emtreeGene frequencyen_US
dc.subject.emtreeGenetic susceptibilityen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.meshAdulten_US
dc.subject.meshBehcet syndromeen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene frequencyen_US
dc.subject.meshGenetic predisposition to diseaseen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-1en_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMultigene Familyen_US
dc.subject.meshPolymorphism, geneticen_US
dc.subject.meshPolymorphism, single nucleotideen_US
dc.subject.meshTurkeyen_US
dc.subject.scopusBehcet Syndrome; Uveitis; Infliximaben_US
dc.subject.wosGenetics & heredityen_US
dc.subject.wosImmunologyen_US
dc.titleIL-1 cluster gene polymorphisms in Turkish patients with Behçet's diseaseen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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