CDP-choline and its endogenous metabolites, cytidine and choline, promote the nerve regeneration and improve the functional recovery of injured rat sciatic nerves

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dc.contributor.authorUlus, İsmail Hakkı
dc.contributor.buuauthorArslan, Erhan
dc.contributor.buuauthorKocaeli, Hasan
dc.contributor.buuauthorBekar, Ahmet
dc.contributor.buuauthorTolunay, Şahsine
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAI-1612-2021tr_TR
dc.contributor.scopusid7004957314tr_TR
dc.contributor.scopusid6603500567tr_TR
dc.contributor.scopusid6603677218tr_TR
dc.contributor.scopusid6602604390tr_TR
dc.date.accessioned2021-12-31T12:56:10Z
dc.date.available2021-12-31T12:56:10Z
dc.date.issued2011-09
dc.description.abstractObjective: Topical cytidine-5'-diphosphocholine (CDP-choline) has been shown to improve the functional recovery and promote the nerve regeneration of injured sciatic nerves in rats. The aims of this study were to test whether CDP-choline was effective at promoting nerve healing when the surgery to repair an injury was delayed and to determine whether the cytidine and/or the choline moieties of CDP-choline contribute to its beneficial actions. Methods: One hundred and fifty Sprague-Dawley rats underwent a surgical procedure that involved damaging the right sciatic nerve and suturing the epineurium. The injured sciatic nerve was either repaired immediately (on the first day) or on the third day after surgery. Rats were assigned to one of five groups and received a topical application of either 0.4 ml of saline (control) or 0.4 ml of 100 mu M CDP-choline, cytidine, choline, or cytidine+choline. Results: The sciatic function index (SFI) of the rats in both groups (those who had their nerve repair immediately versus those on day 3) improved gradually by 4, 8, and 12 weeks after surgery. The percentage recovery in SFI score was significantly higher in rats treated with CDP-choline or cytidine+choline at all time points. Axon count increased by similar to 50% in rats treated either with CDPcholine or cytidine+choline. Treatment with CDP-choline or cytidine+choline reduced scar formation and decreased nerve adherence when the sciatic nerve was repaired immediately, and rats treated with CDPcholine or cytidine+choline had better axonal organization than control rats. Treatment with choline or cytidine alone led to a less marked improvement in SFI score and failed to increase axon count. Conclusion: Our results demonstrate that CDP-choline, as well as the combination of its metabolites, cytidine+choline, improves the functional recovery and promotes the regeneration of injured sciatic nerves treated with immediate or delayed surgical repair in rats.en_US
dc.identifier.citationAslan, E. vd. (2011). "CDP-choline and its endogenous metabolites, cytidine and choline, promote the nerve regeneration and improve the functional recovery of injured rat sciatic nerves". Neurological Research, 33(7), 766-773.en_US
dc.identifier.endpage773tr_TR
dc.identifier.issn0161-6412
dc.identifier.issue7tr_TR
dc.identifier.pubmed21756558tr_TR
dc.identifier.scopus2-s2.0-79960488003tr_TR
dc.identifier.startpage766tr_TR
dc.identifier.urihttps://doi.org/10.1179/1743132811Y.0000000004
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1179/1743132811Y.0000000004
dc.identifier.urihttp://hdl.handle.net/11452/23797
dc.identifier.volume33tr_TR
dc.identifier.wos000292591700014tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalNeurological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectCiticolineen_US
dc.subjectPeripheral nerveen_US
dc.subjectScarringen_US
dc.subjectNicotinic acetylcholine-receptorsen_US
dc.subjectPlus docosahexaenoic aciden_US
dc.subjectAcute ischemic-strokeen_US
dc.subjectPheochromocytoma cellsen_US
dc.subjectBrain-injuryen_US
dc.subjectCiticolineen_US
dc.subjectUridineen_US
dc.subjectInvolvementen_US
dc.subjectSurgeryen_US
dc.subjectModelen_US
dc.subject.emtreeCholineen_US
dc.subject.emtreeCiticolineen_US
dc.subject.emtreeCytidineen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFunctional assessmenten_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeNerve fiber growthen_US
dc.subject.emtreeNerve injuryen_US
dc.subject.emtreeNerve regenerationen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeScar formationen_US
dc.subject.emtreeSciatic nerveen_US
dc.subject.emtreeTreatment durationen_US
dc.subject.emtreeTreatment responseen_US
dc.subject.meshAdministration, cutaneousen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCholineen_US
dc.subject.meshCytidineen_US
dc.subject.meshCytidine diphosphate cholineen_US
dc.subject.meshDisease models, animalen_US
dc.subject.meshFemaleen_US
dc.subject.meshNerve regenerationen_US
dc.subject.meshNeuroprotective agentsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshRecovery of functionen_US
dc.subject.meshSciatic neuropathyen_US
dc.subject.meshTrauma severity indicesen_US
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholineen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosNeurosciencesen_US
dc.titleCDP-choline and its endogenous metabolites, cytidine and choline, promote the nerve regeneration and improve the functional recovery of injured rat sciatic nervesen_US
dc.typeArticle
dc.wos.quartileQ3 (Clinical neurology)en_US
dc.wos.quartileQ4 (Neurosciences)en_US

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