Preoperative chemoradiotherapy in patients with locally advanced rectal cancer

Simple item page
dc.contributor.buuauthorKurt, Meral
dc.contributor.buuauthorÖzkan, Lütfi
dc.contributor.buuauthorKahraman, Sibel
dc.contributor.buuauthorZorluoğlu, Abdullah
dc.contributor.buuauthorGürel, Selim
dc.contributor.buuauthorMemik, Faruk
dc.contributor.buuauthorEngin, Kayıhan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-1637-910Xtr_TR
dc.contributor.orcid0000-0002-2382-290Xtr_TR
dc.contributor.researcheridAAA-3961-2020tr_TR
dc.contributor.scopusid8843050600tr_TR
dc.contributor.scopusid55915679400tr_TR
dc.contributor.scopusid6603789069tr_TR
dc.contributor.scopusid57196930610tr_TR
dc.contributor.scopusid6602076843tr_TR
dc.contributor.scopusid7003706434tr_TR
dc.contributor.scopusid6701813462tr_TR
dc.contributor.scopusid6701768798tr_TR
dc.date.accessioned2022-01-13T08:33:58Z
dc.date.available2022-01-13T08:33:58Z
dc.date.issued2005
dc.description.abstractBackground/Aims: To determine the percentage of responders and the resectability rate for patients with locally advanced carcinoma of the rectum treated by infusional 5-fluorouracil chemotherapy and pelvic radiation. Methodology: Twenty-four patients with a diagnosis of locally advanced unresectable rectal cancer received preoperative 5-fluorouracil by intravenous infusion at the dose of 250-300mg/m(2)/day concurrent with pelvic radiation (median 50.4 Gy/28 fractions). Surgery was performed with a mean delay of 15 days after completion of irradiation and included 11 abdominoperineal resections and five anal sphincterpreserving procedures. Results: The median follow-up was 22 months. Complete histological response occurred in 6%, and tumor down-staging in 58% of cases. There was a significant difference in the rate of local control based on the distance of the tumor from the anal verge (> 5.4cm; p=0.046). Our results have suggested the importance of the total dose on the local control (p=0.061). Higher local failure rate has been observed with prolonged treatment time (p=0.018). With metastasis-free survival as the endpoint, only stage (p=0.027) was a statistically significant prognostic factor. Conclusions: The favorable influence of higher doses of preoperative radiotherapy on pathologic stage has been observed. Even after preoperative radiotherapy, postoperative staging remained a prognostic factor.en_US
dc.identifier.citationKurt, M. vd. (2005). "Preoperative chemoradiotherapy in patients with locally advanced rectal cancer". Hepato-gastroenterology, 52(64), 1095-1100.en_US
dc.identifier.endpage1100tr_TR
dc.identifier.issn0172-6390
dc.identifier.issue64tr_TR
dc.identifier.pubmed16001638tr_TR
dc.identifier.scopus2-s2.0-21744450709tr_TR
dc.identifier.startpage1095tr_TR
dc.identifier.urihttp://hdl.handle.net/11452/24070
dc.identifier.volume52tr_TR
dc.identifier.wos000230154300027tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherH G E Update Medical Publishingen_US
dc.relation.journalHepato-gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastroenterology & hepatologyen_US
dc.subjectSurgeryen_US
dc.subjectPreoperativeen_US
dc.subjectChemoradiotherapyen_US
dc.subjectRectal canceren_US
dc.subjectRadiation-therapyen_US
dc.subjectPrognostic implicationsen_US
dc.subjectColorectal-canceren_US
dc.subjectPostoperative radiotherapyen_US
dc.subjectTrialen_US
dc.subjectChemoradiationen_US
dc.subjectAdenocarcinomaen_US
dc.subjectCarcinomaen_US
dc.subjectResectionen_US
dc.subjectPatternsen_US
dc.subject.emtreeFluorouracilen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer controlen_US
dc.subject.emtreeCancer diagnosisen_US
dc.subject.emtreeCancer radiotherapyen_US
dc.subject.emtreeCancer stagingen_US
dc.subject.emtreeCancer surgeryen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMetastasisen_US
dc.subject.emtreePreoperative treatmenten_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreePrognosisen_US
dc.subject.emtreeRectum abdominoperineal resectionen_US
dc.subject.emtreeRectum canceren_US
dc.subject.meshAdenocarcinomaen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshAntimetabolites, antineoplasticen_US
dc.subject.meshChemotherapy, adjuvanten_US
dc.subject.meshDigestive system surgical proceduresen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorouracilen_US
dc.subject.meshFollow-up studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshNeoplasm stagingen_US
dc.subject.meshRadiotherapy dosageen_US
dc.subject.meshRadiotherapy, adjuvanten_US
dc.subject.meshRectal neoplasmsen_US
dc.subject.meshTreatment outcomeen_US
dc.subject.scopusRectum Tumor; Chemoradiotherapy; Organ Preservationen_US
dc.subject.wosGastroenterology & hepatologyen_US
dc.subject.wosSurgeryen_US
dc.titlePreoperative chemoradiotherapy in patients with locally advanced rectal canceren_US
dc.typeArticle
dc.wos.quartileQ3 (Surgery)en_US
dc.wos.quartileQ4 (Gastroenterology & hepatology)en_US

Files

License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science