Possible neuroprotective effects of magnesium sulfate and melatonin as both pre- and post-treatment in a neonatal hypoxic-ischemic rat model

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dc.contributor.buuauthorÇetinkaya, Merih
dc.contributor.buuauthorAlkan, Tülin
dc.contributor.buuauthorÖzyener, Fadil
dc.contributor.buuauthorKafa, İlker Mustafa
dc.contributor.buuauthorKurt, Mustafa Ayberk
dc.contributor.buuauthorKöksal, Nilgün
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Çocuk Saǧlıǧı ve Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Psikoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-4606-6596tr_TR
dc.contributor.orcid0000-0003-3368-8123tr_TR
dc.contributor.researcheridAAH-1792-2021tr_TR
dc.contributor.researcheridAAG-7125-2021tr_TR
dc.contributor.researcheridAAH-1641-2021tr_TR
dc.contributor.researcheridAAG-8393-2021tr_TR
dc.contributor.researcheridAAR-4341-2020tr_TR
dc.contributor.scopusid23994946300tr_TR
dc.contributor.scopusid6601953747tr_TR
dc.contributor.scopusid6506242143tr_TR
dc.contributor.scopusid8450193200tr_TR
dc.contributor.scopusid35603735000tr_TR
dc.contributor.scopusid7003323615tr_TR
dc.date.accessioned2021-11-30T07:37:29Z
dc.date.available2021-11-30T07:37:29Z
dc.date.issued2011
dc.description.abstractBackground: Perinatal hypoxia-ischemia is a major cause of mortality and long-term neurological deficits. Objectives: The objective of this study was to compare the effects of two neuroprotective agents; magnesium sulfate and melatonin, administered alone or in combination, on brain infarct volume and TUNEL positivity in a neonatal hypoxic-ischemic (HI) rat model. Methods: After being anesthetized, 7-day-old pups (n = 80) underwent ischemia followed by exposure to hypoxia for 2 h. The pups were then divided equally and randomly into 4 groups in order to receive the vehicle (saline, control group), magnesium sulfate, melatonin or a combination of magnesium sulfate and melatonin. Treatments were administered intraperitoneally three times; the first being just before ischemia, the second after hypoxia and the third 24 h after the second dose. The pups were sacrificed on postnatal day 10, their brains harvested and evaluated for infarct volume and neuronal apoptosis. Results: Percent infarcted brain volume was significantly reduced in pups receiving the drugs (either magnesium sulfate, melatonin or their combination) compared with those receiving the vehicle. In addition, TUNEL staining showed markedly reduced numbers of TUNEL-positive cells per unit area in the CA1, CA3 and dentate gyrus regions of the hippocampus and in the cortex. However, no statistically significant differences were found regarding percent infarcted brain volume and number of TUNEL-positive cells among the drug-treated groups. Conclusions: Magnesium sulfate and melatonin, two agents acting at different stages of HI brain damage, administered either alone or in combination, significantly reduced the percent infarcted brain volume and TUNEL positivity, suggesting that these agents may confer a possible benefit in the treatment of infants with HI encephalopathy.tr_TR
dc.identifier.citationÇetinkaya, M. vd. (2011). ''Possible neuroprotective effects of magnesium sulfate and melatonin as both pre- and post-treatment in a neonatal hypoxic-ischemic rat model''.Neonatology, 99(4), 302-310.tr_TR
dc.identifier.endpage310tr_TR
dc.identifier.issn1661-7800
dc.identifier.issn1661-7819
dc.identifier.issue4tr_TR
dc.identifier.pubmed21135566tr_TR
dc.identifier.scopus2-s2.0-78649713485tr_TR
dc.identifier.startpage302tr_TR
dc.identifier.urihttps://doi.org/10.1159/000320643
dc.identifier.urihttps://www.karger.com/article/Abstract/320643
dc.identifier.urihttp://hdl.handle.net/11452/22872
dc.identifier.volume99tr_TR
dc.identifier.wos000292043200011tr_TR
dc.indexed.pubmedPubmedtr_TR
dc.indexed.scopusScopustr_TR
dc.indexed.wosSCIEtr_TR
dc.language.isoentr_TR
dc.publisherKargertr_TR
dc.relation.journalNeonatologytr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitak108S128tr_TR
dc.rightsinfo:eu-repo/semantics/closedAccesstr_TR
dc.subjectPediatricstr_TR
dc.subjectApoptosistr_TR
dc.subjectHypoxia-ischemiatr_TR
dc.subjectMagnesium sulfatetr_TR
dc.subjectMelatonintr_TR
dc.subjectNeuroprotectiontr_TR
dc.subjectBrain-injurytr_TR
dc.subjectBirth asphyxiatr_TR
dc.subjectNewborn ratstr_TR
dc.subjectCell-deathtr_TR
dc.subjectDamagetr_TR
dc.subjectConsequencestr_TR
dc.subjectPretreatmenttr_TR
dc.subjectInfusiontr_TR
dc.subjectProtectstr_TR
dc.subjectInfantstr_TR
dc.subjectRattustr_TR
dc.subject.emtreeMagnesium sulfatetr_TR
dc.subject.emtreeMelatonintr_TR
dc.subject.emtreeSodium chloridetr_TR
dc.subject.emtreeAdrenal cortextr_TR
dc.subject.emtreeAnimal experimenttr_TR
dc.subject.emtreeAnimal modeltr_TR
dc.subject.emtreeAnimal tissuetr_TR
dc.subject.emtreeApoptosistr_TR
dc.subject.emtreeBrain hypoxiatr_TR
dc.subject.emtreeBrain infarction sizetr_TR
dc.subject.emtreeBrain ischemiatr_TR
dc.subject.emtreeConference papertr_TR
dc.subject.emtreeControlled studytr_TR
dc.subject.emtreeDentate gyrustr_TR
dc.subject.emtreeHippocampal CA1 regiontr_TR
dc.subject.emtreeHippocampal CA3 regiontr_TR
dc.subject.emtreeHypoxic ischemic encephalopathytr_TR
dc.subject.emtreeNeuroprotectiontr_TR
dc.subject.emtreeNonhumantr_TR
dc.subject.emtreePriority journaltr_TR
dc.subject.emtreeRandomized controlled trialtr_TR
dc.subject.emtreeRattr_TR
dc.subject.meshAlgorithmstr_TR
dc.subject.meshAnimalstr_TR
dc.subject.meshAnimals, newborntr_TR
dc.subject.meshDisease models, animaltr_TR
dc.subject.meshDrug administration scheduletr_TR
dc.subject.meshDrug combinationstr_TR
dc.subject.meshDrug evaluation, preclinicaltr_TR
dc.subject.meshFemaletr_TR
dc.subject.meshHypoxia-ischemia, braintr_TR
dc.subject.meshMagnesium sulfatetr_TR
dc.subject.meshMelatonintr_TR
dc.subject.meshNeuroprotective agentstr_TR
dc.subject.meshPregnancytr_TR
dc.subject.meshRatstr_TR
dc.subject.meshRats, sprague-dawleytr_TR
dc.subject.scopusEclampsia; Magnesium Sulfate; Pregnancy Toxemiatr_TR
dc.subject.wosPediatricstr_TR
dc.titlePossible neuroprotective effects of magnesium sulfate and melatonin as both pre- and post-treatment in a neonatal hypoxic-ischemic rat modeltr_TR
dc.typeArticle
dc.wos.quartileQ1tr_TR

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