Pemfigusta desmoglein antikor serum düzeyleri ile direkt immünofloresan bulgularının hastalığın klinik aktivitesi ile ilişkisi

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dc.contributor.buuauthorYılmaz, Mediha
dc.contributor.buuauthorBaşkan, Emel Bülbül
dc.contributor.buuauthorBudak, Ferah Ah
dc.contributor.buuauthorSarıcaoğlu, Hayriye
dc.contributor.buuauthorTunalı, Şükran
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Deri&Zührevi Hastalıklar Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-0144-3263tr_TR
dc.contributor.researcheridAAH-1388-2021tr_TR
dc.contributor.researcheridF-4657-2014tr_TR
dc.contributor.scopusid35148700000tr_TR
dc.contributor.scopusid6602518817tr_TR
dc.contributor.scopusid6701913697tr_TR
dc.contributor.scopusid6603722836tr_TR
dc.contributor.scopusid7004191748tr_TR
dc.date.accessioned2022-10-31T11:15:01Z
dc.date.available2022-10-31T11:15:01Z
dc.date.issued2010-10-01
dc.description.abstractBackground and Design: Pemphigus is an autoimmune disease that results in blistering of the skin and mucous membranes. In this study, we investigated the relationship between disease activity and remission with ELISA scores and direct immunofluorescence (IF) - two methods used for the detection of antibodies against desmoglein-1 (dsg-1) and desmoglein-3 (dsg-3) that are responsible for blister formation. Material and Method: Twenty-three pemphigus vulgaris patients and two pemphigus foliaceus patients were enrolled in the study. The serum levels of anti-dsg-1 and anti-dsg-3 antibodies were measured with ELISA before therapy and at 3, 6, and 12 month of clinical remission. Concurrently, direct IF was performed on perilesional skin during active disease and on normal buttock skin/lower lip mucosa in remission. The tests were repeated if relapse has occured. Results: Anti-dsg-1 was detected in 17 (73.9%) pemphigus vulgaris patients and anti-dsg-3 in 23 (100%) pemphigus vulgaris patients. In two pemphigus foliaceus patients, anti-dsg-1 values were positive, while anti-dsg-3 values were negative. A statistically significant correlation was seen between anti-dsg-1 antibody serum levels and skin severity scores (r: 0.577; p: 0.003), as well as between anti-dsg-3 antibody serum levels and oral mucosa severity scores (r: 0.539; p: 0.008). Direct IF results in 16 patients (84.2%) who achieved complete remission were negative. In 9 patients who relapsed, elevated serum values of anti-dsg-1 and/or anti-dsg3 were also found. Increase in serum antibody levels was detected 1-4 months before the relapse in three of them. Conclusion: In this study, we observed that serum desmoglein antibody levels correlated with disease severity and activity. In clinical remission, serial measurements of desmoglein antibodies can provide a guide for clinical follow-up and treatment modification.en_US
dc.identifier.citationYılmaz, M. vd. (2011). "Pemfigusta desmoglein antikor serum düzeyleri ile direkt immünofloresan bulgularının hastalığın klinik aktivitesi ile ilişkisi". Türkderm - Turkish Archives of Dermatology and Venereology, 45(2), 22-27.tr_TR
dc.identifier.endpage27tr_TR
dc.identifier.issn1019-214X
dc.identifier.issn1308-6294
dc.identifier.issue2tr_TR
dc.identifier.scopus2-s2.0-79960190837tr_TR
dc.identifier.startpage22tr_TR
dc.identifier.urihttps://doi.org/10.4274/turkderm.45.18
dc.identifier.urihttps://www.journalagent.com/z4/vi.asp?pdir=turkderm&plng=eng&un=TURKDERM-98705
dc.identifier.urihttp://hdl.handle.net/11452/29275
dc.identifier.volume45tr_TR
dc.identifier.wos000209157100005tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.trdizinTrDizintr_TR
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherDeri ve Zührevi Hastalıklar Derneğitr_TR
dc.relation.journalTürkderm - Turkish Archives of Dermatology and Venereologytr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDermatologyen_US
dc.subjectPemphigus vulgarisen_US
dc.subjectPemphigus foliaceusen_US
dc.subjectDirect immunofluorescenceen_US
dc.subjectDesmoglein antibodiesen_US
dc.subjectDisease activityen_US
dc.subjectLinked-immunosorbent-assayen_US
dc.subjectDisease-activityen_US
dc.subjectAutoantibodiesen_US
dc.subjectVulgarisen_US
dc.subjectSeverityen_US
dc.subjectIggen_US
dc.subjectAutoimmunityen_US
dc.subjectFrequencyen_US
dc.subjectReceptorsen_US
dc.subjectRemissionen_US
dc.subject.emtreeDesmoglein 1 antibodyen_US
dc.subject.emtreeDesmoglein 3 antibodyen_US
dc.subject.emtreeDesmoglein antibodyen_US
dc.subject.emtreeAntibody blood levelen_US
dc.subject.emtreeAntibody detectionen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlisteren_US
dc.subject.emtreeButtocken_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeDisease activityen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeEnzyme linked immunosorbent assayen_US
dc.subject.emtreeImmunofluorescenceen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLipen_US
dc.subject.emtreeMouth mucosaen_US
dc.subject.emtreePemphigusen_US
dc.subject.emtreePemphigus foliaceusen_US
dc.subject.emtreePemphigus vulgarisen_US
dc.subject.emtreeRemissionen_US
dc.subject.scopusPemphigus; Desmoglein 3; Pemphigus and Fogo Selvagemen_US
dc.subject.wosDermatologyen_US
dc.titlePemfigusta desmoglein antikor serum düzeyleri ile direkt immünofloresan bulgularının hastalığın klinik aktivitesi ile ilişkisitr_TR
dc.title.alternativeRelationship of serum levels of anti-desmoglein antibodies and direct immunofluorescence findings with clinical activity of pemphigusen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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